Diffuse Idiopathic Skeletal Hyperostosis (DISH) Treatment & Management

1. Holgate RL, Steyn M. Diffuse idiopathic skeletal hyperostosis: Diagnostic, clinical, and paleopathological considerations. Clin Anat. 2016 Mar 23. [QxMD MEDLINE Link].

2. Nascimento FA, Gatto LA, Lages RO, Neto HM, Demartini Z, Koppe GL. Diffuse idiopathic skeletal hyperostosis: A review. Surg Neurol Int. 2014. 5 (Suppl 3):S122-5. [QxMD MEDLINE Link]. [Full Text].

3. Westerveld LA, Verlaan JJ, Oner FC. Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J. 2009 Feb. 18(2):145-56. [QxMD MEDLINE Link]. [Full Text].

4. Luo TD, Varacallo M. Diffuse Idiopathic Skeletal Hyperostosis (DISH). 2020 Jan. [QxMD MEDLINE Link]. [Full Text].

5. Rotés-Querol J. Clinical manifestations of diffuse idiopathic skeletal hyperostosis (DISH). Br J Rheumatol. 1996 Dec. 35 (12):1193-4. [QxMD MEDLINE Link]. [Full Text].

6. Rothschild BM, Woods R. Old World spondylarthropathy: the gorilla connection. Arthritis Rheum. 1988 Jul. 31(7):934-5. [QxMD MEDLINE Link].

7. Ferigolo J. Estudos multidisciplinares. Goncalves de Araujo AJ, Ferreira LF, eds. Non-human Vertebrate Paleopathology. Brazil: Panorama; 1988. 213-34.

8. Bjorkengren AG, Sartoris DJ, Shermis S, et al. Patterns of paravertebral ossification in the prehistoric saber-toothed cat. AJR Am J Roentgenol. 1987 Apr. 148(4):779-82. [QxMD MEDLINE Link].

9. McDonald JN, Bartlett CS Jr. An associated musk ox skeleton from Saltville, Virginia. J Vert Paleontol. 1983. 2:453-470.

10. Moodie RL. Studies in Paleopathology: XX. Vertebral lesions in the sabre-tooth, Pleistocene of California, resembling the so-called Myositis Ossificans Progressiva, compared with certain ossifications in the dinosaurs. Ann Med Hist. 1927. 9:91-102.

11. Rothschild BM. Scientifically rigorous reptile and amphibian osseous pathology: Lessons for forensic herpetology from comparative and paleo-pathology. Applied Herpetology. 2008. 10:39-116.

12. Rothschild BM. Skeletal paleopathology of rheumatic diseases: the subprimate connection. McCarty DJ, ed. Arthritis and Allied Conditions. 11th ed. Philadelphia, Pa: Lea and Febiger; 1989. 3-7.

13. Rothschild BM. Diffuse idiopathic skeletal hyperostosis as reflected in the paleontologic record: dinosaurs and early mammals. Semin Arthritis Rheum. 1987 Nov. 17(2):119-25. [QxMD MEDLINE Link].

14. Rothschild BM, Berman D. Fusion of caudal vertebrae in late Jurassic sauropods. J Vert Paleontol. 1991. 11(1):29-36.

15. Rothschild BM, Martin LD. Paleopathology: Disease in the Fossil Record. Boca Raton, Fla: CRC Press;. 1993.

16. Fornasier VL, Littlejohn G, Urowitz MB, et al. Spinal entheseal new bone formation: the early changes of spinal diffuse idiopathic skeletal hyperostosis. J Rheumatol. 1983 Dec. 10(6):939-47. [QxMD MEDLINE Link].

17. Rothschild BM. Diffuse idiopathic skeletal hyperostosis (DISH): misconceptions and reality. Clin Rheumatol. 1985. 4:207-12.

18. Mori K, Kasahara T, Mimura T, Nishizawa K, Nakamura A, Imai S. Prevalence of thoracic diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. J Orthop Sci. 2017 Jan. 22 (1):38-42. [QxMD MEDLINE Link].

19. Ono M, Russell WJ, Kudo S, et al. Ossification of the thoracic posterior longitudinal ligament in a fixed population. Radiological and neurological manifestations. Radiology. 1982 May. 143(2):469-74. [QxMD MEDLINE Link].

20. Tsuyama N. Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res. 1984 Apr. 71-84. [QxMD MEDLINE Link].

21. Westerveld LA, van Ufford HM, Verlaan JJ, Oner FC. The prevalence of diffuse idiopathic skeletal hyperostosis in an outpatient population in the Netherlands. J Rheumatol. 2008 Aug. 35(8):1635-8. [QxMD MEDLINE Link].

22. Cassim B, Mody GM, Rubin DL. The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. Br J Rheumatol. 1990 Apr. 29 (2):131-2. [QxMD MEDLINE Link].

23. Schlapbach P, Beyeler C, Gerber NJ, et al. Diffuse idiopathic skeletal hyperostosis (DISH) of the spine: a cause of back pain? A controlled study. Br J Rheumatol. 1989 Aug. 28(4):299-303. [QxMD MEDLINE Link].

24. Holton KF, Denard PJ, Yoo JU, Kado DM, Barrett-Connor E, Marshall LM. Diffuse Idiopathic Skeletal Hyperostosis and Its Relation to Back Pain Among Older Men: The MrOS Study. Semin Arthritis Rheum. 2011 Mar 3. [QxMD MEDLINE Link].

25. Katzman WB, Huang MH, Kritz-Silverstein D, Barrett-Connor E, Kado DM. Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc. 2017 Jul. 65 (7):1476-1481. [QxMD MEDLINE Link].

26. Yamada K, Satoh S, Abe Y, Yanagibashi Y, Hyakumachi T, Masuda T. Diffuse Idiopathic Skeletal Hyperostosis Extended to the Lumbar Segment Is a Risk Factor of Reoperation in Patients Treated Surgically for Lumbar Stenosis. Spine (Phila Pa 1976). 2018 Oct 15. 43 (20):1446-1453. [QxMD MEDLINE Link].

27. Julkunen H, Knekt P, Aromaa A. Spondylosis deformans and diffuse idiopathic skeletal hyperostosis (DISH) in Finland. Scand J Rheumatol. 1981. 10(3):193-203. [QxMD MEDLINE Link].

28. Uehara M, Takahashi J, Ikegami S, Tokida R, Nishimura H, Sakai N, et al. Prevalence of Diffuse Idiopathic Skeletal Hyperostosis in the General Elderly Population: A Japanese Cohort Survey Randomly Sampled From a Basic Resident Registry. Clin Spine Surg. 2020 Apr. 33 (3):123-127. [QxMD MEDLINE Link].

29. Kaffel D, Kchir H. Dysphagia related to diffuse idiopathic skeletal hyperostosis (DISHphagia). Clin Case Rep. 2019 Nov. 7 (11):2265-2266. [QxMD MEDLINE Link]. [Full Text].

30. Olivieri I, D'Angelo S, Cutro MS, Padula A, Peruz G, Montaruli M, et al. Diffuse idiopathic skeletal hyperostosis may give the typical postural abnormalities of advanced ankylosing spondylitis. Rheumatology (Oxford). 2007 Nov. 46(11):1709-11. [QxMD MEDLINE Link].

31. Merkel PA. Rheumatic Disease and Endocrinopathies. Klippel JH, Stone JH, Crofford LJ, White PH, eds. Primer on the Rheumatic Diseases. 13th ed. New York: Springer; 2008. 479-83.

32. Dan Lantsman C, Herman A, Verlaan JJ, Stern M, Mader R, Eshed I. Abdominal fat distribution in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis patients compared to controls. Clin Radiol. 2018 Oct. 73 (10):910.e15-910.e20. [QxMD MEDLINE Link].

33. Mader R, Novofestovski I, Adawi M, Lavi I. Metabolic Syndrome and Cardiovascular Risk in Patients with Diffuse Idiopathic Skeletal Hyperostosis. Semin Arthritis Rheum. 2008 Feb 25. [QxMD MEDLINE Link].

34. Daragon A, Mejjad O, Czernichow P, et al. Vertebral hyperostosis and diabetes mellitus: a case-control study. Ann Rheum Dis. 1995 May. 54(5):375-8. [QxMD MEDLINE Link].

35. Resnick D, Niwayama G. Diagnosis of Bone and Joint Disorders. 2nd ed. Philadelphia PA: WB Saunders; 1563-615.

36. Oudkerk SF, de Jong PA, Attrach M, Luijkx T, Buckens CF, Mali WP, et al. Diagnosis of diffuse idiopathic skeletal hyperostosis with chest computed tomography: inter-observer agreement. Eur Radiol. 2017 Jan. 27 (1):188-194. [QxMD MEDLINE Link]. [Full Text].

37. Yunoki M, Suzuki K, Uneda A, Okubo S, Hirashita K, Yoshino K. The Importance of Recognizing Diffuse Idiopathic Skeletal Hyperostosis for Neurosurgeons: A Review. Neurol Med Chir (Tokyo). 2016 Mar 28. [QxMD MEDLINE Link]. [Full Text].

38. Slonimsky E, Leibushor N, Aharoni D, Lidar M, Eshed I. Pelvic enthesopathy on CT is significantly more prevalent in patients with diffuse idiopathic skeletal hyperostosis (DISH) compared with matched control patients. Clin Rheumatol. 2016 Jul. 35 (7):1823-7. [QxMD MEDLINE Link].

39. Katzman WB, Parimi N, Mansoori Z, Nardo L, Kado DM, Cawthon PM, et al. Cross-Sectional and Longitudinal Associations of Diffuse Idiopathic Skeletal Hyperostosis and Thoracic Kyphosis in Older Men and Women. Arthritis Care Res (Hoboken). 2017 Aug. 69 (8):1245-1252. [QxMD MEDLINE Link]. [Full Text].

40. Lantsman CD, Barkay G, Friedlander A, Barbi M, Stern M, Eshed I. Whole Spine CT Scan for the Detection of Acute Spinal Fractures in Diffuse Idiopathic Skeletal Hyperostosis Patients Who Sustained Low-energy Trauma. Spine (Phila Pa 1976). 2020 Apr 23. [QxMD MEDLINE Link].

41. Kuperus JS, Westerveld LA, Rutges JA, Alblas J, van Rijen MH, Bleys RL, et al. Histological characteristics of diffuse idiopathic skeletal hyperostosis. J Orthop Res. 2016 Apr 21. [QxMD MEDLINE Link].

42. Seawright AA, English PB, Gartner RJ. Hypervitaminosis A and hyperostosis of the cat. Nature. 1965 Jun 12. 206(989):1171-2. [QxMD MEDLINE Link].

43. Yoshimatsu Y, Tobino K, Maeda K, Kubota K, Haruta Y, Adachi H, et al. Management of Airway Obstruction due to Diffuse Idiopathic Skeletal Hyperostosis in the Cervical Spine: A Case Report and Literature Review. Intern Med. 2018 Aug 24. [QxMD MEDLINE Link].

44. Seidler TO, Pèrez Àlvarez JC, Wonneberger K, Hacki T. Dysphagia caused by ventral osteophytes of the cervical spine: clinical and radiographic findings. Eur Arch Otorhinolaryngol. 2008 Jun 28. [QxMD MEDLINE Link].

45. Burduk PK, Wierzchowska M, Grzelalak L, Dalke K, Mierzwinski J. Diffuse idiopathic skeletal hyperostosis inducted stridor and dysphagia. Otolaryngol Pol. 2008. 62(2):138-40. [QxMD MEDLINE Link].

46. Israel Z, Mosheiff R, Gross E, Muggia-Sullam M, Floman Y. Hyperextension fracture-dislocation of the thoracic spine with paraplegia in a patient with diffuse idiopathic skeletal hyperostosis. J Spinal Disord. 1994 Oct. 7(5):455-7. [QxMD MEDLINE Link].

47. Königshausen M, Dudda M, Merle C, Schildhauer TA, Fehmer T. Thoracic vertebral body fracture after total hip replacement in diffuse idiopathic skeletal hyperostosis. Orthopedics. 2012 Jun. 35(6):e1000-4. [QxMD MEDLINE Link].

48. Paley D, Schwartz M, Cooper P, Harris WR, Levine AM. Fractures of the spine in diffuse idiopathic skeletal hyperostosis. Clin Orthop Relat Res. 1991 Jun. 22-32. [QxMD MEDLINE Link].

49. Hendrix RW, Melany M, Miller F, Rogers LF. Fracture of the spine in patients with ankylosis due to diffuse skeletal hyperostosis: clinical and imaging findings. AJR Am J Roentgenol. 1994 Apr. 162(4):899-904. [QxMD MEDLINE Link].

50. Matejka J. [Hyperextension injuries of the thoracolumbar spine]. Zentralbl Chir. 2006 Feb. 131(1):75-9. [QxMD MEDLINE Link].

Bruce M Rothschild, MD Professor of Medicine, IU Health; Research Associate, Carnegie Museum

Bruce M Rothschild, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Rheumatology, International Skeletal Society, New York Academy of Sciences, Sigma Xi, Society of Skeletal Radiology

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

George H Thompson, MD Director of Pediatric Orthopedic Surgery, Rainbow Babies and Children’s Hospital, University Hospitals Case Medical Center, and MetroHealth Medical Center; Professor of Orthopedic Surgery and Pediatrics, Case Western Reserve University School of Medicine

George H Thompson, MD is a member of the following medical societies: American Orthopaedic Association, Scoliosis Research Society, Pediatric Orthopaedic Society of North America, American Academy of Orthopaedic Surgeons

Disclosure: Received none from OrthoPediatrics for consulting; Received salary from Journal of Pediatric Orthopaedics for management position; Received none from SpineForm for consulting; Received none from SICOT for board membership.

Jeffrey D Thomson, MD Professor of Orthopedic Surgery, University of Connecticut School of Medicine; Director of Orthopedic Surgery, Connecticut Children’s Medical Center; Vice President of Medical Staff, Connecticut Children's Medical Center

Jeffrey D Thomson, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, Pediatric Orthopaedic Society of North America, Scoliosis Research Society

Disclosure: Nothing to disclose.

Mininder S Kocher, MD, MPH Associate Professor of Orthopedic Surgery, Harvard Medical School/Harvard School of Public Health; Associate Director, Division of Sports Medicine, Department of Orthopedic Surgery, Children's Hospital Boston

Mininder S Kocher, MD, MPH is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Sports Medicine, Pediatric Orthopaedic Society of North America, American Association for the History of Medicine, American Orthopaedic Society for Sports Medicine, Massachusetts Medical Society

Disclosure: Received consulting fee from Smith & Nephew Endoscopy for consulting; Received consulting fee from EBI Biomet for consulting; Received consulting fee from OrthoPediatrics for consulting; Received stock from Pivot Medical for consulting; Received consulting fee from pediped for consulting; Received royalty from WB Saunders for none; Received stock from Fixes-4-Kids for consulting.

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