Wermer Syndrome (MEN Type 1) Differential Diagnoses

Updated: Feb 18, 2015
  • Author: Laura Williams, MD; Chief Editor: George T Griffing, MD  more...
  • Print

Diagnostic Considerations

Hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN1) must be separated from other familial forms of hypercalcemia, including familial parathyroid hyperplasia and familial adenomatous hyperparathyroidism. Familial hypocalciuric hypercalcemia may also have a similar presentation. These latter 2 syndromes have no pancreatic or pituitary manifestations.

Conditions other than Zollinger-Ellison syndrome (ZES) that are associated with elevated serum gastrin levels include retained gastric antrum, gastric outlet obstruction, hypercalcemia, massive small bowel resection, atrophic gastritis, and treatment with proton pump inhibitors.

Differential Diagnoses