Rajasekaran S, Devendra A, Ramesh P, Dheenadayalan J, Kamal CA. Initial management of open fractures. Tornetta P III, Ricci WM, Ostrum RF, McQueen MM, McKee MD, Court-Brown CM, eds. Rockwood and Green’s Fractures in Adults. 9th ed. Philadelphia: Wolters Kluwer; 2020. Vol 1: Chap 15.
Scherl SA, Kay RM. Management of the multiply injured child. Waters PM, Skaggs DL, Flynn JM, eds. Rockwood and Wilkins’ Fractures in Children. 9th ed. Philadelphia: Wolters Kluwer; 2020. Chap 4.
Mosheiff R. Open fractures. Buckley RE, Moran CG, Apivatthakakul T, eds. AO Principles of Fracture Management. 3rd ed. New York: Thieme; 2017. Chap 4.2.
Diwan A, Eberlin KR, Smith RM. The principles and practice of open fracture care, 2018. Chin J Traumatol. 2018 Aug. 21 (4):187-192. [QxMD MEDLINE Link].
Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976 Jun. 58 (4):453-8. [QxMD MEDLINE Link].
Gustilo RB, Mendoza RM, Williams DN. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma. 1984 Aug. 24 (8):742-6. [QxMD MEDLINE Link].
Orthopaedic Trauma Association: Open Fracture Study Group. A new classification scheme for open fractures. J Orthop Trauma. 2010 Aug. 24 (8):457-64. [QxMD MEDLINE Link].
Hao J, Cuellar DO, Herbert B, Kim JW, Chadayammuri V, Casemyr N, et al. Does the OTA Open Fracture Classification Predict the Need for Limb Amputation? A Retrospective Observational Cohort Study on 512 Patients. J Orthop Trauma. 2016 Apr. 30 (4):194-8. [QxMD MEDLINE Link].
Ghoshal A, Enninghorst N, Sisak K, Balogh ZJ. An interobserver reliability comparison between the Orthopaedic Trauma Association's open fracture classification and the Gustilo and Anderson classification. Bone Joint J. 2018 Feb. 100-B (2):242-246. [QxMD MEDLINE Link].
American College of Surgeons Trauma Programs. Advanced Trauma Life Support. American College of Surgeons. Available at http://www.facs.org/trauma/atls/index.html. 2022; Accessed: April 28, 2022.
Okike K, Bhattacharyya T. Trends in the management of open fractures. A critical analysis. J Bone Joint Surg Am. 2006 Dec. 88 (12):2739-48. [QxMD MEDLINE Link].
Johnson EN, Burns TC, Hayda RA, Hospenthal DR, Murray CK. Infectious complications of open type III tibial fractures among combat casualties. Clin Infect Dis. 2007 Aug 15. 45 (4):409-15. [QxMD MEDLINE Link].
Neubauer T, Bayer GS, Wagner M. Open fractures and infection. Acta Chir Orthop Traumatol Cech. 2006 Oct. 73 (5):301-12. [QxMD MEDLINE Link].
Stewart DG Jr, Kay RM, Skaggs DL. Open fractures in children. Principles of evaluation and management. J Bone Joint Surg Am. 2005 Dec. 87 (12):2784-98. [QxMD MEDLINE Link].
Skaggs DL, Friend L, Alman B, Chambers HG, Schmitz M, Leake B, et al. The effect of surgical delay on acute infection following 554 open fractures in children. J Bone Joint Surg Am. 2005 Jan. 87 (1):8-12. [QxMD MEDLINE Link].
Hubbard EW, Riccio AI. Pediatric Orthopedic Trauma: An Evidence-Based Approach. Orthop Clin North Am. 2018 Apr. 49 (2):195-210. [QxMD MEDLINE Link].
Mooney JF 3rd, Argenta LC, Marks MW, Morykwas MJ, DeFranzo AJ. Treatment of soft tissue defects in pediatric patients using the V.A.C. system. Clin Orthop Relat Res. 2000 Jul. 26-31. [QxMD MEDLINE Link].
Court-Brown CM, Biant LC, Clement ND, Bugler KE, Duckworth AD, McQueen MM. Open fractures in the elderly. The importance of skin ageing. Injury. 2015 Feb. 46 (2):189-94. [QxMD MEDLINE Link].
Koval KJ, Lurie J, Zhou W, Sparks MB, Cantu RV, Sporer SM, et al. Ankle fractures in the elderly: what you get depends on where you live and who you see. J Orthop Trauma. 2005 Oct. 19 (9):635-9. [QxMD MEDLINE Link].
Clement ND, Beauchamp NJ, Duckworth AD, McQueen MM, Court-Brown CM. The outcome of tibial diaphyseal fractures in the elderly. Bone Joint J. 2013 Sep. 95-B (9):1255-62. [QxMD MEDLINE Link].
Tampe U, Widmer LW, Weiss RJ, Jansson KÅ. Mortality, risk factors and causes of death in Swedish patients with open tibial fractures - a nationwide study of 3, 777 patients. Scand J Trauma Resusc Emerg Med. 2018 Jul 25. 26 (1):62. [QxMD MEDLINE Link].
Toole WP, Elliott M, Hankins D, Rosenbaum C, Harris A, Perkins C. Are low-energy open ankle fractures in the elderly the new geriatric hip fracture?. J Foot Ankle Surg. 2015 Mar-Apr. 54 (2):203-6. [QxMD MEDLINE Link].
Patzakis MJ, Harvey JP Jr, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am. 1974 Apr. 56 (3):532-41. [QxMD MEDLINE Link].
Zalavras CG, Patzakis MJ. Open fractures: evaluation and management. J Am Acad Orthop Surg. 2003 May-Jun. 11 (3):212-9. [QxMD MEDLINE Link].
Samai K, Vilella A. Update in Therapeutics: Prophylactic Antibiotics in Open Fractures. J Trauma Nurs. 2018 Mar/Apr. 25 (2):83-86. [QxMD MEDLINE Link].
Takahara S, Tokura T, Nishida R, Uefuji A, Ichimura K, Nishihara H, et al. Ampicillin/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study. Injury. 2022 Apr. 53 (4):1517-1522. [QxMD MEDLINE Link].
Sudduth JD, Moss JA, Spitler CA, Pham VH, Jones LC, Brown JT, et al. Open Fractures: Are We Still Treating the Same Types of Infections?. Surg Infect (Larchmt). 2020 Nov. 21 (9):766-772. [QxMD MEDLINE Link].
Chang Y, Bhandari M, Zhu KL, Mirza RD, Ren M, Kennedy SA, et al. Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations. JBJS Rev. 2019 Feb. 7 (2):e1. [QxMD MEDLINE Link].
Messner J, Papakostidis C, Giannoudis PV, Kanakaris NK. Duration of Administration of Antibiotic Agents for Open Fractures: Meta-Analysis of the Existing Evidence. Surg Infect (Larchmt). 2017 Nov/Dec. 18 (8):854-867. [QxMD MEDLINE Link].
Stennett CA, OʼHara NN, Sprague S, Petrisor B, Jeray KJ, Leekha S, et al. Effect of Extended Prophylactic Antibiotic Duration in the Treatment of Open Fracture Wounds Differs by Level of Contamination. J Orthop Trauma. 2020 Mar. 34 (3):113-120. [QxMD MEDLINE Link].
Garner MR, Sethuraman SA, Schade MA, Boateng H. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. J Am Acad Orthop Surg. 2020 Apr 15. 28 (8):309-315. [QxMD MEDLINE Link].
Vanvelk N, Chen B, Van Lieshout EMM, Zalavras C, Moriarty TF, Obremskey WT, et al. Duration of Perioperative Antibiotic Prophylaxis in Open Fractures: A Systematic Review and Critical Appraisal. Antibiotics (Basel). 2022 Feb 23. 11 (3):[QxMD MEDLINE Link]. [Full Text].
Rhee P, Nunley MK, Demetriades D, Velmahos G, Doucet JJ. Tetanus and trauma: a review and recommendations. J Trauma. 2005 May. 58 (5):1082-8. [QxMD MEDLINE Link].
Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002 Dec. 84 (12):2123-34. [QxMD MEDLINE Link].
Jones AL. Recombinant human bone morphogenic protein-2 in fracture care. J Orthop Trauma. 2005 Nov-Dec. 19 (10 Suppl):S23-5. [QxMD MEDLINE Link].
Trueta J. Reflections on the past and present treatment of war wounds and fractures. Mil Med. 1976 Apr. 141 (4):255-8. [QxMD MEDLINE Link].
Lin DL, Kirk KL, Murphy KP, McHale KA, Doukas WC. Evaluation of orthopaedic injuries in Operation Enduring Freedom. J Orthop Trauma. 2004 May-Jun. 18 (5):300-5. [QxMD MEDLINE Link].
Radotra I, Azimi DY, Maamoun W. The use of smartphone-application based medical photography for open fractures: A national survey of orthoplastic affiliated Major Trauma Centres in England. Injury. 2022 Mar 5. [QxMD MEDLINE Link].
Anglen JO, Apostoles S, Christensen G, Gainor B. The efficacy of various irrigation solutions in removing slime-producing Staphylococcus. J Orthop Trauma. 1994 Oct. 8 (5):390-6. [QxMD MEDLINE Link].
Petrisor B, Jeray K, Schemitsch E, Hanson B, Sprague S, Sanders D, et al. Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons. BMC Musculoskelet Disord. 2008 Jan 23. 9:7. [QxMD MEDLINE Link].
Crowley DJ, Kanakaris NK, Giannoudis PV. Debridement and wound closure of open fractures: the impact of the time factor on infection rates. Injury. 2007 Aug. 38 (8):879-89. [QxMD MEDLINE Link].
FLOW Investigators, Bhandari M, Jeray KJ, Petrisor BA, et al. A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med. 2015 Dec 31. 373 (27):2629-41. [QxMD MEDLINE Link].
Cross WW 3rd, Swiontkowski MF. Treatment principles in the management of open fractures. Indian J Orthop. 2008 Oct. 42 (4):377-86. [QxMD MEDLINE Link]. [Full Text].
Pollak AN. Timing of débridement of open fractures. J Am Acad Orthop Surg. 2006. 14 (10 Spec No.):S48-51. [QxMD MEDLINE Link].
Schenker ML, Yannascoli S, Baldwin KD, Ahn J, Mehta S. Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review. J Bone Joint Surg Am. 2012 Jun 20. 94 (12):1057-64. [QxMD MEDLINE Link].
Mener A, Staley CA, Lunati MP, Pflederer J, Reisman WM, Schenker ML. Is Operative Debridement Greater Than 24 Hours Post-admission Associated With Increased Likelihood of Post-operative Infection?. J Surg Res. 2020 Mar. 247:461-468. [QxMD MEDLINE Link].
Zalavras CG, Patzakis MJ, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res. 2004 Oct. (427):86-93. [QxMD MEDLINE Link].
Pelissier P, Masquelet AC, Bareille R, Pelissier SM, Amedee J. Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res. 2004 Jan. 22 (1):73-9. [QxMD MEDLINE Link].
Wenke JC, Owens BD, Svoboda SJ, Brooks DE. Effectiveness of commercially-available antibiotic-impregnated implants. J Bone Joint Surg Br. 2006 Aug. 88 (8):1102-4. [QxMD MEDLINE Link].
Morgenstern M, Vallejo A, McNally MA, Moriarty TF, Ferguson JY, Nijs S, et al. The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis. Bone Joint Res. 2018 Jul. 7 (7):447-456. [QxMD MEDLINE Link].
Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, et al. The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures. J Orthop Trauma. 2007 Jan. 21 (1):11-7. [QxMD MEDLINE Link].
Herscovici D Jr, Sanders RW, Scaduto JM, Infante A, DiPasquale T. Vacuum-assisted wound closure (VAC therapy) for the management of patients with high-energy soft tissue injuries. J Orthop Trauma. 2003 Nov-Dec. 17 (10):683-8. [QxMD MEDLINE Link].
Liu X, Zhang H, Cen S, Huang F. Negative pressure wound therapy versus conventional wound dressings in treatment of open fractures: A systematic review and meta-analysis. Int J Surg. 2018 May. 53:72-79. [QxMD MEDLINE Link].
Grant-Freemantle MC, Ryan ÉJ, Flynn SO, Moloney DP, Kelly MA, Coveney EI, et al. The Effectiveness of Negative Pressure Wound Therapy Versus Conventional Dressing in the Treatment of Open Fractures: A Systematic Review and Meta-Analysis. J Orthop Trauma. 2020 May. 34 (5):223-230. [QxMD MEDLINE Link].
Qian H, Lei T, Hu Y. Negative pressure wound therapy versus gauze dressings in managing open fracture wound of lower limbs: A meta-analysis of randomized controlled trials. Foot Ankle Surg. 2022 Apr 6. [QxMD MEDLINE Link].
Jenkinson RJ, Kiss A, Johnson S, Stephen DJ, Kreder HJ. Delayed wound closure increases deep-infection rate associated with lower-grade open fractures: a propensity-matched cohort study. J Bone Joint Surg Am. 2014 Mar 5. 96 (5):380-6. [QxMD MEDLINE Link].
Scharfenberger AV, Alabassi K, Smith S, Weber D, Dulai SK, Bergman JW, et al. Primary Wound Closure After Open Fracture: A Prospective Cohort Study Examining Nonunion and Deep Infection. J Orthop Trauma. 2017 Mar. 31 (3):121-126. [QxMD MEDLINE Link].
Weitz-Marshall AD, Bosse MJ. Timing of closure of open fractures. J Am Acad Orthop Surg. 2002 Nov-Dec. 10 (6):379-84. [QxMD MEDLINE Link].
[Guideline] Hauser CJ, Adams CA Jr, Eachempati SR, Council of the Surgical Infection Society. Surgical Infection Society guideline: prophylactic antibiotic use in open fractures: an evidence-based guideline. Surg Infect (Larchmt). 2006 Aug. 7 (4):379-405. [QxMD MEDLINE Link].
Fischer MD, Gustilo RB, Varecka TF. The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am. 1991 Oct. 73 (9):1316-22. [QxMD MEDLINE Link].