Growth Hormone Replacement in Older Men Clinical Presentation

Updated: Dec 14, 2015
  • Author: Angela Gentili, MD; Chief Editor: George T Griffing, MD  more...
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GHD in adults causes changes in body composition that are similar to those occurring with normal aging, such as the following:

  • Decrease in lean body mass

  • Increase in total and abdominal fat [13]

  • Decrease in muscle strength

  • Decrease in bone mineral density




The pathophysiology of somatopause is confounded by several variables that can contribute to the decline in GH secretion associated with aging: adiposity, decreased production of sex steroid hormones, decreased physical fitness, fragmented sleep, and malnutrition (see Pathophysiology).