McCune-Albright Syndrome Questions & Answers

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Questions & Answers

Overview

What are features of McCune-Albright syndrome (MAS)?

What are the manifestations of McCune-Albright syndrome (MAS)?

Which lab tests are performed in the workup of McCune-Albright syndrome (MAS)?

Which imaging studies are performed in the workup of McCune-Albright syndrome (MAS)?

Which studies may be considered in the workup of McCune-Albright syndrome (MAS)?

How is precocious puberty treated in McCune-Albright syndrome (MAS)?

How is polyostotic fibrous dysplasia (PFD) treated in McCune-Albright syndrome (MAS)?

How is hyperthyroidism treated in McCune-Albright syndrome (MAS)?

How are endocrine abnormalities treated in McCune-Albright syndrome (MAS)?

What is the role of surgery in the treatment of McCune-Albright syndrome (MAS)?

What is McCune-Albright syndrome (MAS)?

Which endocrine syndromes are associated with McCune-Albright syndrome (MAS)?

What is the role of genetics in the etiology of McCune-Albright syndrome?

How is McCune-Albright syndrome diagnosed?

Which specialist consultation is beneficial to patients with McCune-Albright syndrome?

What is the pathophysiology of McCune-Albright syndrome (MAS)?

Which conditions are associated with McCune-Albright syndrome?

Which malignancies are associated with McCune-Albright syndrome?

What causes McCune-Albright syndrome (MAS)?

What causes the classic triad of features in McCune-Albright syndrome?

What is the prevalence of McCune-Albright syndrome (MAS)?

At what age is McCune-Albright syndrome (MAS) typically diagnosed?

At are the sexual and racial predilections of McCune-Albright syndrome (MAS)?

What is the prognosis of McCune-Albright syndrome (MAS)?

What is included in patient education about McCune-Albright syndrome (MAS)?

Presentation

Which clinical history findings are characteristic of café-au-lait pigmentation in McCune-Albright syndrome (MAS)?

What is the focus of clinical history in the evaluation of McCune-Albright syndrome (MAS)?

Which clinical history findings are characteristic of precocious puberty in McCune-Albright syndrome (MAS)?

Which clinical history findings are characteristic of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

Which clinical history findings are characteristic of McCune-Albright syndrome (MAS)?

Which physical findings are characteristic of café-au-lait pigmentation in McCune-Albright syndrome (MAS)?

Which physical findings are characteristic of McCune-Albright syndrome (MAS)?

Which physical findings are characteristic of precocious puberty in McCune-Albright syndrome (MAS)?

Which physical findings are characteristic of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

Which physical findings are characteristic of endocrine disorders in McCune-Albright syndrome (MAS)?

What are the possible complications of precocious puberty in McCune-Albright syndrome (MAS)?

What are the possible complications of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

What are the possible complications of endocrine disorders in McCune-Albright syndrome (MAS)?

What are the possible cardiac complications of McCune-Albright syndrome (MAS)?

DDX

Why should McCune-Albright syndrome (MAS) be considered in patients with recurrent fractures?

Which conditions are included in the differential diagnoses of McCune-Albright syndrome (MAS)?

What are the differential diagnoses for McCune-Albright Syndrome?

Workup

What are the initial studies in the workup of McCune-Albright syndrome (MAS)?

What is the role of hormone measurement in the diagnosis of McCune-Albright syndrome?

What is the role of blood and urinary chemistries in the diagnosis of McCune-Albright syndrome?

What is the role of thyroid testing in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of ACTH measurement in the diagnosis of McCune-Albright Syndrome?

What is the role of dexamethasone suppression testing in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of 24-hour urinary free cortisol (UFC) testing in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of serum growth hormone testing in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of polymerase chain reaction (PCR) assay in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of plain radiography in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of ultrasonography in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of CT scanning in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of MRI in the diagnosis of McCune-Albright syndrome (MAS)?

What is the role of bone scanning in the workup of McCune-Albright syndrome (MAS)?

What is the role of bone biopsy in the diagnosis of McCune-Albright syndrome (MAS)?

Which histologic findings are characteristic of McCune-Albright syndrome (MAS)?

Treatment

How is McCune-Albright syndrome (MAS) treated?

What is the role of pharmacologic therapy in the treatment of precocious puberty in McCune-Albright syndrome (MAS)?

What is the role of pharmacologic therapy in the treatment of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

What is the role of pharmacologic therapy in the treatment of hyperthyroidism in McCune-Albright syndrome (MAS)?

What is the role of pharmacologic therapy in the treatment of infantile Cushing syndrome in McCune-Albright syndrome (MAS)?

What is the role of pharmacologic therapy in the treatment of gigantism and acromegaly in McCune-Albright syndrome (MAS)?

What is the role of pharmacologic therapy in the treatment of the endocrine syndromes in McCune-Albright syndrome (MAS)?

What is the role of surgery in the treatment of precocious puberty in McCune-Albright syndrome (MAS)?

What is the role of surgery in the treatment of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

What is the role of surgery in the treatment of hyperthyroidism in McCune-Albright syndrome (MAS)?

What is the role of adrenalectomy in the treatment of other manifestations of McCune-Albright syndrome (MAS)?

Which dietary modifications are used in the treatment of McCune-Albright syndrome (MAS)?

Which specialist consultations are beneficial to patients with McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of patients with McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of precocious puberty in McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of hyperthyroidism in McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of infantile Cushing syndrome in McCune-Albright syndrome (MAS)?

What is included in the long-term monitoring of growth hormones (GH) excess in McCune-Albright syndrome (MAS)?

Medications

What is the role of medications in the treatment of McCune-Albright syndrome (MAS)?

Which medications in the drug class Vitamins, Fat-Soluble are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Antithyroid Agents are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Estrogen Receptor Antagonists are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Bisphosphonates are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Antiparkinson Agents, Dopamine Agonists are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Somatostatin Analogues are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Corticosteroids are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Progestins are used in the treatment of McCune-Albright Syndrome?

Which medications in the drug class Aromatase Inhibitors are used in the treatment of McCune-Albright Syndrome?