Alloimmunization From Transfusions Questions & Answers

Updated: Sep 08, 2017
  • Author: Douglas Blackall, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Questions & Answers

Overview

What is alloimmunization from blood transfusions?

What are the consequences of alloimmunization to blood-based antigens?

What is the pathophysiology of alloimmunization?

What is the pathophysiology of alloimmunized refractoriness to platelet transfusions?

What is the pathophysiology of delayed hemolytic transfusion reactions (DHTR)?

What is the prevalence of delayed hemolytic transfusion reactions (DHTR)?

What is the prevalence of alloimmunized refractoriness to platelet transfusions?

What is the mortality and morbidity associated with alloimmunization from transfusions?

What are the racial predilections of alloimmunization from transfusions?

What are the sexual predilections of alloimmunization from transfusions?

Which age groups have the highest prevalence of alloimmunization from transfusions?

Presentation

Which physical findings are characteristic of delayed hemolytic transfusion reactions (DHTR)?

Which physical findings are characteristic of alloimmunized refractoriness to platelet transfusions?

What causes alloimmunization from transfusions?

DDX

Which conditions are included in the differential diagnoses of delayed hemolytic transfusion reactions (DHTR)?

Which conditions are included in the differential diagnoses of alloimmunized refractoriness to platelet transfusions?

What are the differential diagnoses for Alloimmunization From Transfusions?

Workup

What is the role of lab testing in the workup of delayed hemolytic transfusion reactions (DHTR)?

What is the role of lab testing in the workup of alloimmunized refractoriness to platelet transfusions?

Treatment

How are delayed hemolytic transfusions reactions (DHTR) treated?

How is alloimmunized refractoriness to platelet transfusions treated?

Which specialist consultations are beneficial to patients with alloimmunization from transfusions?

Medications

What is the role of medications in the treatment of alloimmunization from transfusions?

Which medications in the drug class Cytotoxic agents are used in the treatment of Alloimmunization From Transfusions?

Which medications in the drug class Immunosuppressive agents are used in the treatment of Alloimmunization From Transfusions?

Follow-up

When is inpatient care indicated in the treatment of delayed hemolytic transfusion reactions (DHTR)?

When is inpatient care indicated in the treatment of alloimmunized refractoriness to platelet transfusions?

How are delayed hemolytic transfusion reactions (DHTR) prevented?

How is alloimmunized refractoriness to platelet transfusions prevented?

What is included in patient education about alloimmunization from transfusions?