Angioedema Questions & Answers

Updated: Sep 04, 2018
  • Author: Huamin Henry Li, MD, PhD, CPI; Chief Editor: Michael A Kaliner, MD  more...
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Questions & Answers

Overview

What is angioedema?

What are the signs and symptoms of angioedema?

What is included in the physical exam of suspected angioedema?

What can result from angioedema?

What is the role of aeroallergen screening in suspected angioedema?

Which lab tests are performed in the workup of angioedema with urticaria?

Which lab tests may be considered for the workup of chronic or recurrent angioedema?

What tests may be helpful for the diagnosis of angioedema when a specific condition is suspected?

What is the role of imaging studies in the diagnosis of angioedema?

What is the primary goal of medical treatment for angioedema?

When is epinephrine indicated for the treatment of angioedema?

Which medications are used in the management of angioedema?

When is surgery indicated for angioedema?

What is angioedema?

Which areas of the body are most commonly affected by angioedema?

When is angioedema of greater concern?

What is the most common symptom of angioedema?

What are the signs and symptoms of angioedema?

What are the manifestations of angioedema?

How does etiology affect the treatment strategy for angioedema?

What causes the onset of angioedema?

What is the role of vasoactive mediators in the pathogenesis of angioedema?

What is the pathophysiology of histamine-mediated angioedema?

What is the pathophysiology of bradykinin-mediated angioedema?

Which cellular components are involved in the pathogenesis of angioedema?

How do the pathophysiology of urticaria and angioedema differ?

How can urticarial and angioedema be differentiated?

What is the pathophysiology of angioedema with urticaria?

What is the pathophysiology of angioedema without urticaria?

What types of hereditary angioedema (HAE) have been identified?

What is characteristic of type III angioedema?

How are the different types of angioedema named under the new classification system?

What is characteristic of type I angioedema?

What is characteristic of type II angioedema?

What is pseudoallergic angioedema (PAE)?

What are the types of nonallergic angioedema?

What are the causes of physically induced angioedema?

What are some common triggers of angioedema attacks?

What causes angioedemas?

What types of angioedemas have unidentifiable etiologies?

Which conditions are associated with angioedemas?

What is hypersensitivity (allergic) angioedema?

What are the causes of hereditary angioedema (HAE)?

What are the causes of acquired angioedema (C1-INH-AAE)?

What is ACE inhibitor–induced angioedema (ACEI-AAE or AIIA)?

What are the causes of idiopathic angioedema (IAE)?

What is the role of Helicobacter pylori infection in the etiology of hereditary angioedema (HAE)?

What is the biological mechanism of hereditary angioedema (HAE) type III?

What is the role of Gleich syndrome in the etiology of angioedema?

What is the prevalence of autoantibodies in angioedema?

What is the prevalence of angioedema in the US?

What is the prevalence of angioedema with urticaria in the US?

What is the prevalence of hereditary angioedema (HAE) in the US?

What is the global prevalence of angioedema?

How does the prevalence of angioedema vary by age?

How does the prevalence of angioedema vary by sex?

How does the prevalence of angioedema vary by race?

What is the prognosis of angioedema?

What information about angioedema should patients be given?

Where can patients with angioedema get information regarding their condition?

Presentation

What should be the focus of clinical history in suspected angioedema?

How should the focus of history vary for different types of angioedema?

Where in the body can edema occur during angioedema?

What are symptoms of angioedema?

What are the clinical symptoms of hereditary angioedema (HAE), idiopathic angioedema (IAE), and drug-induced angioedema?

What are triggers of an angioedema attack?

What is the purpose of skin exam for angioedema?

Which physical findings are characteristic of abdominal (intestinal mucosal) angioedema?

How should swelling due to angioedema be documented?

How is angioedema classified?

What are features of angioedema with urticaria?

What are the characteristics of acquired angioedema (AAE) without urticaria?

What are the characteristics of hereditary angioedema (HAE) without urticaria?

What is the prevalence of each subtype of angioedema?

What are complications of angioedema?

DDX

How are the different types of angioedema differentiated?

What are the differential diagnoses for Angioedema?

Workup

How is angioedema diagnosed?

Which diagnostic tests should be performed in suspected angioedema without urticaria?

What is the role of lab tests in the diagnosis of angioedema?

Which lab findings suggest C1-INH-hereditary angioedema (HAE) types I and II?

Which diagnostic tests are performed for recurrent angioedema without a clear trigger?

Which lab tests may be helpful in the diagnosis of angioedema?

Which histologic findings are characteristic of angioedema?

What is the role of allergy testing in the diagnosis of angioedema?

Which radiologic findings are characteristic of angioedema?

What is the role of imaging studies for the diagnosis of angioedema?

Treatment

What are the World Allergy Organization (WAO) recommendations regarding prophylaxis and screening in hereditary angioedema (HAE)?

What is the emergency department treatment of angioedema?

When is inpatient care indicated for the treatment of angioedema?

What is the most important consideration with laryngeal angioedema?

When is admission to the ICU indicated for angioedema?

What are triggers for angioedema?

Which types of angioedema must be differentiated when urticaria is absent?

How is angioedema managed?

Which organization has published treatment guidelines for chronic urticaria/angioedema?

What are BSAC treatment guidelines for adults with urticaria?

What are BSAC treatment guidelines for adults with angioedema and urticaria?

What are BSAC treatment guidelines for adults with angioedema without urticaria?

What are the World Allergy Organization (WAO) recommendations for the management of hereditary angioedema (HAE)?

What is histaminergic angioedema (IH-AAE)?

What are the treatment options for histaminergic angioedema (IH-AAE)?

What are the dosing recommendations for treating histaminergic angioedema (IH-AAE)?

Which medications are used to treat histaminergic angioedema (IH-AAE)?

What are treatment options for moderate-to-severe histaminergic angioedema (IH-AAE)?

How is laryngeal swelling and airway obstruction caused by angioedema treated?

What is the role of leukotriene antagonists in the treatment of histaminergic angioedema (IH-AAE)?

What is the role of doxepin in the treatment of histaminergic angioedema (IH-AAE)?

What is the role of immunomodulatory drugs in the treatment of histaminergic angioedema (IH-AAE)?

What is the role of corticosteroids in the treatment of histaminergic angioedema (IH-AAE)?

What are treatment options for nonhistaminergic angioedema (InH-AAE)?

What is the role of fresh frozen plasma (FFP) in the treatment of nonhistaminergic angioedema (InH-AAE)?

What are treatment options for hereditary angioedema (HAE)?

What are treatment options for acute hereditary angioedema (HAE)?

What are the Hereditary Angioedema International Working Group recommendations treatment of hereditary angioedema (HAE)?

What are the treatment guidelines for gynecologic and obstetric issues in patients with C1-INH-hereditary angioedema (HAE)?

What are the FDA approved medications for management of hereditary angioedema (HAE)?

What is the role of fresh frozen plasma (FFP) in the prevention of angioedema?

When is long-term prophylaxis indicated in patients with angioedema?

Which medications are used to prevent angioedema?

Which drugs may provoke an attack of angioedema?

How is angioedema prevented in patients with food allergies?

What medications are used in the treatment of idiopathic histaminergic angioedema (IH-AAE)?

When is corticosteroid treatment indicated for the treatment of angioedema?

What specialist consultations are needed for the management of angioedema?

Medications

What is the primary goal of medical therapy for angioedema?

Which medications are used to treat histamine-mediated angioedema?

Which medications are used to treat bradykinin-mediated angioedema?

Which anti-inflammatory drugs are used to treat angioedema?

What are treatment options for recalcitrant angioedema?

Which medications in the drug class Monoclonal Antibodies, Anti-asthmatics are used in the treatment of Angioedema?

Which medications in the drug class Immunomodulators are used in the treatment of Angioedema?

Which medications in the drug class Antifibrinolytic Agents are used in the treatment of Angioedema?

Which medications in the drug class Androgens are used in the treatment of Angioedema?

Which medications in the drug class Corticosteroids are used in the treatment of Angioedema?

Which medications in the drug class Tricyclic Antidepressants are used in the treatment of Angioedema?

Which medications in the drug class Leukotriene Receptor Antagonists are used in the treatment of Angioedema?

Which medications in the drug class Histamine H2 Antagonists are used in the treatment of Angioedema?

Which medications in the drug class Antihistamines, 2nd Generation are used in the treatment of Angioedema?

Which medications in the drug class Antihistamines, 1st-Generation are used in the treatment of Angioedema?

Which medications in the drug class Alpha/Beta-Adrenergic Agonists are used in the treatment of Angioedema?