Complement Deficiencies Medication

Updated: Feb 15, 2022
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Medication Summary

Cephalosporins are often used for treatment of N meningitidis infection in patients with complement deficiency. Third- or fourth-generation cephalosporins are used for coverage of infection with any of the encapsulated bacteria.



Class Summary

Therapy must cover all likely pathogens in the context of this clinical setting. Antibiotic selection should be guided by blood culture sensitivity results whenever feasible.

Ceftriaxone (Rocephin)

Third-generation cephalosporin with broad-spectrum, gram-negative activity; lower efficacy against gram-positive organisms; higher efficacy against resistant organisms. Arrests bacterial growth by binding to one or more penicillin-binding proteins.

Cefepime (Maxipime)

Fourth-generation cephalosporin with good gram-negative coverage. Similar to third-generation cephalosporins but has better gram-positive coverage.