Complement Deficiencies Questions & Answers

Updated: Apr 02, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Questions & Answers

Overview

What are complement deficiencies?

What is the pathophysiology of complement deficiencies?

What is the prevalence of complement deficiencies?

What is the mortality and morbidity associated with complement deficiencies?

What are the racial predilections of complement deficiencies?

What are the sexual predilections of complement deficiencies?

At what age do complement deficiencies typically present?

Presentation

Which clinical history findings are characteristic of complement deficiencies?

Which clinical history findings are characteristic of opsonization-caused complement deficiencies?

Which clinical history findings are characteristic of defects in cell lysis causing complement deficiencies?

Which clinical history findings are characteristic of immune complex diseases in complement deficiencies?

Which physical findings are characteristic of complement deficiencies?

What causes complement deficiencies?

DDX

What are the differential diagnoses for Complement Deficiencies?

Workup

What is the role of lab tests in the workup of complement deficiencies?

What is the role of imaging studies in the workup of complement deficiencies?

Which tests are performed in the workup of classic complement pathway deficiencies?

What is the role of lumbar puncture in the workup of complement deficiencies?

Treatment

How are complement deficiencies treated?

Which specialist consultations are beneficial to patients with complement deficiencies?

Which dietary modifications are used in the treatment of complement deficiencies?

Which activity modifications are used in the treatment of complement deficiencies?

Who should undergo complement screening?

Medications

What is the role of medications in the treatment of complement deficiencies?

Which medications in the drug class Antibiotics are used in the treatment of Complement Deficiencies?

Follow-up

What screenings should be performed for patients with known complement deficiency?

When is inpatient care indicated for complement deficiencies?

What is the role of cephalosporins in the treatment of complement deficiencies?

Which vaccines should be given to patients with complement deficiencies?

What are the possible complications of complement deficiencies?

What is the prognosis of complement deficiencies?

What is included in patient education about complement deficiencies?