Delayed Hypersensitivity Reactions Medication

Updated: May 07, 2018
  • Author: Stuart L Abramson, MD, PhD; Chief Editor: Michael A Kaliner, MD  more...
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Medication

Medication Summary

Medical treatment differs greatly depending on the specific disease entity. Only a few medications are discussed. In addition to drugs mentioned below, a drug that may augment cell-mediated immunity is cimetidine, which is an H2 receptor blocker that acts as a reverse antagonist and may augment cell-mediated immunity. [9]

Induction of a delayed hypersensitivity reaction may be used therapeutically. For example, alopecia areata may be treated by topical cutaneous sensitization to diphenylcyclopropenone at the affected sites. The reaction is maintained by repeated applications using a subsensitizing concentration.

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Corticosteroids

Class Summary

Have anti-inflammatory properties and cause profound and varied metabolic effects. Modify the body's immune response to diverse stimuli.

Triamcinolone (Aristocort)

Helps treat inflammatory dermatosis responsive to steroids. Decreases inflammation by suppressing migration of PMN leukocytes and reversing capillary permeability.

Mometasone (Elocon)

May depress formation, release, and activity of endogenous chemical mediators of inflammation.

Prednisone (Deltasone, Orasone, Meticorten, Sterapred)

May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

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