Immunoglobulin A Deficiency Differential Diagnoses

Updated: May 15, 2018
  • Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, MD  more...
  • Print

Diagnostic Considerations

Primary immunodeficiencies include agammaglobulinemia, hypoglobulinemia, selective deficiency of IgG subclasses with or without immunoglobulin A deficiency (IgAD), X-linked agammaglobulinemia, autosomal recessive agammaglobulinemia, impaired polysaccharide responsiveness, B-cell disorders, T-cell disorders, combined B- and T-cell disorders, common variable immunodeficiency (CVID), severe combined variable immunodeficiency, transient hypogammaglobulinemia of infancy, and Wiskott-Aldrich syndrome.

Acquired immunodeficiencies include drug-induced hypogammaglobulinemia (most commonly, long-term therapy with anticonvulsants and steroids), AIDS, and postinfectious hypogammaglobulinemia.

Recurrent sinopulmonary infections include cystic fibrosis, immotile cilia syndrome, endobronchial obstruction, and recurrent aspiration.

Differential Diagnoses