Immunoglobulin D Deficiency Clinical Presentation

Updated: Sep 13, 2016
  • Author: Camellia L Hernandez, MD; Chief Editor: Michael A Kaliner, MD  more...
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Presentation

History

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  • No specific signs or symptoms are associated with isolated IgD deficiency; therefore, this condition is usually discovered incidentally during immunological laboratory testing (eg, quantitative serum immunoglobulin levels).

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Physical

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  • A patient with low IgD levels but no concurrent immunoglobulin deficiencies of other classes or other immune defects typically does not develop specific physical findings associated with low or absent IgD levels.

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Causes

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  • Family studies from one report indicate that low serum IgD levels may be inherited in an autosomal recessive fashion. [9]

  • Another study found several families with possible characteristics of autosomal recessive inheritance, and other families with a pattern more consistent with multiple allele involvement. This latter report also suggested an increased frequency of certain HLA antigens in individuals with low IgD levels. [10]

  • An HLA association has also been seen in a Basque population, which suggested a partially penetrant dominant susceptibility gene for IgD deficiency. [11] These findings have been further supported in another recent study. [12]

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