Immunoglobulin D Deficiency Treatment & Management

Updated: Dec 07, 2021
  • Author: Camellia L Hernandez, MD; Chief Editor: Michael A Kaliner, MD  more...
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Medical Care

After excluding more extensive immunodeficiency, possibly with the assistance of an allergist or clinical immunologist, patients do not need further routine care. Longitudinal follow-up examinations with periodic quantitative immunoglobulin measurements and surveillance for immune, infectious, or rheumatologic disease are advised.

Consider performing periodic (every 1–2 y) serial determinations of quantitative immunoglobulin (all classes) levels in patients with isolated IgD deficiency that was discovered incidentally.



If a nonspecialist discovers the IgD deficiency, refer the patient to an allergist or clinical immunologist to help exclude other more serious related conditions.