Immunoglobulin G Deficiency Differential Diagnoses

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael A Kaliner, MD  more...
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Diagnostic Considerations

The wide range of normal levels of IgG subclasses in children may make the differential diagnosis of IgG deficiency difficult until the patient is as old as 4-5 years, at which time the IgG concentration approaches adult levels. Specific antibody responses to required immunizations may be more revealing and of greater significance than total IgG or IgG subclass measurements. [8, 9, 10]