Immunoglobulin M Deficiency Differential Diagnoses

Updated: Nov 14, 2016
  • Author: Iftikhar Hussain, MD; Chief Editor: Michael A Kaliner, MD  more...
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DDx

Diagnostic Considerations

Common variable immunodeficiency

Defects in B lymphocytes and T lymphocytes

Wiskott-Aldrich syndrome (WAS) also presents with low levels of IgM, but levels of IgA and IgE are often elevated. WAS is an X-linked disorder manifesting in infancy with eczema, thrombocytopenia, and recurrent pyogenic infections.

A case report of 37-year-old female presenting with recurrent pneumonia associated with a bronchial polyp and dermal symptoms found to have low levels of IgM and IgG4 was reported. [10] Subclass deficiencies might be considered in patients with IgM deficiency.

Differential Diagnoses