Burkitt Lymphoma and Burkitt-like Lymphoma Questions & Answers

Updated: Dec 20, 2019
  • Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the signs and symptoms of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) diagnosed?

Which systems are used to stage Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which lab tests are performed in the workup of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which imaging studies are performed in the workup of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which invasive procedures are performed in the workup of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which medications are used in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is included in the supportive treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) classified?

When was Burkitt lymphoma (BL) first identified?

What causes Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of Epstein-Barr Virus (EBV) and malaria infection in the etiology of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of genetics in the etiology of Burkitt lymphoma?

What is the US prevalence of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the global prevalence of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which patient groups have the highest prevalence of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the prognosis of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the prognosis of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) in children?

What is the prognosis of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) in adults?

What are the possible complications of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the possible complications of chemotherapy to treat Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is included in patient education about Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Presentation

Which clinical history findings are characteristic of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How does the clinical presentation of Burkitt lymphoma (BL) differ by variant?

Which physical findings are characteristic of Burkitt-like lymphoma (BLL)?

Which physical findings are characteristic of Burkitt lymphoma (BL)?

What are the most common clinical findings for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the most commonly used staging system for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) staged?

What is the NCI staging system for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is risk determined in Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

DDX

Which condition are included in the differential diagnoses of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) differentiated from DLBCL?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) differentiated from lymphoblastic and mantle cell lymphomas?

What are the differential diagnoses for Burkitt Lymphoma and Burkitt-like Lymphoma?

Workup

What is included in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of lab testing in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of CBC and coagulation studies in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of serum chemistries in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of imaging studies in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of cardiac imaging studies in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of biopsy in the diagnostic workup for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which histologic findings are characteristic of Burkitt cells?

Which histologic findings are characteristic of Burkitt lymphoma (BL)?

Which histologic findings are characteristic of Burkitt-like lymphoma (BLL)?

Treatment

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) treated?

How is tumor lysis syndrome prevented in patients with Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which specialist consultations are beneficial to patients with Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

When is patient transfer indicated for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which dietary modifications are used in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which activity modifications are needed during the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of chemotherapy in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the possible adverse reactions to chemotherapy for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of CNS prophylaxis in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the CODOX-M/IVAC regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the CODOX-M regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the IVAC regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) and CNS involvement treated?

What is the CALGB 9251 regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the hyper-CVAD regimen for the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the CNS prophylaxis when the hyper-CVAD regimen is used to treat Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of rituximab in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is response to chemotherapy evaluated in patients with Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is salvage therapy for relapsed/refractory Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of stem cell transplantation (SCT) in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of stem cell transplantation (SCT) in the treatment of primary refractory Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of stem cell transplantation (SCT) in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) with partial remission?

What is the role of stem cell transplantation (SCT) in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL) with clinical remission?

What is the role of stem cell transplantation (SCT) in the treatment of relapsed Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of stem cell transplantation (SCT) and graft versus leukemia effect in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of surgery in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is included in the long-term monitoring of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

When is inpatient treatment indicated for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the role of hemodialysis in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Guidelines

What are the most commonly used classification schemas for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What is the WHO classification of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the NCCN diagnostic guidelines for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

How is risk stratified for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the NCCN treatment guidelines for Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

What are the NCCN guidelines for surveillance of patients with Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Medications

What is the role of medications in the treatment of Burkitt lymphoma/Burkitt-like lymphoma (BL/BLL)?

Which medications in the drug class Urate-Oxidase Enzymes are used in the treatment of Burkitt Lymphoma and Burkitt-like Lymphoma?

Which medications in the drug class Glucocorticoids are used in the treatment of Burkitt Lymphoma and Burkitt-like Lymphoma?

Which medications in the drug class Alkylating Agents are used in the treatment of Burkitt Lymphoma and Burkitt-like Lymphoma?