Acute Promyelocytic Leukemia Questions & Answers

Updated: May 03, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is acute promyelocytic leukemia (APL)?

When was acute promyelocytic leukemia (APL) first recognized?

What is the pathophysiology of acute promyelocytic leukemia (APL)?

What is the prevalence of acute promyelocytic leukemia (APL)?

What is the prognosis of acute promyelocytic leukemia (APL)?

What is the role of WBC count in determining the prognosis of acute promyelocytic leukemia (APL)?

Other than WBC count, what are prognostic indicators for acute promyelocytic leukemia (APL)?

Presentation

What are the signs and symptoms of acute promyelocytic leukemia (APL)?

Which clinical history findings are characteristic of acute promyelocytic leukemia (APL)?

Which physical findings are characteristic of acute promyelocytic leukemia (APL)?

DDX

Which conditions are included in the differential diagnoses of acute promyelocytic leukemia (APL)?

What are the differential diagnoses for Acute Promyelocytic Leukemia?

Workup

How is acute promyelocytic leukemia (APL) diagnosed?

Which lab tests are performed in the workup of acute promyelocytic leukemia (APL)?

What is the role of lumbar puncture in the workup of acute promyelocytic leukemia (APL)?

What is the role of CSF in the workup of acute promyelocytic leukemia (APL)?

What is the role of cardiac function testing in the workup of acute promyelocytic leukemia (APL)?

What is the role of bone marrow biopsy in the workup of acute promyelocytic leukemia (APL)?

What are the morphologic variants of acute promyelocytic leukemia (APL)?

Which histologic findings are characteristic of acute promyelocytic leukemia (APL)?

Treatment

How is acute promyelocytic leukemia (APL) treated?

Which specialist consultations are beneficial to patients with acute promyelocytic leukemia (APL)?

How is low- and intermediate-risk acute promyelocytic leukemia (APL) treated?

How is high-risk acute promyelocytic leukemia (APL) treated?

What is the risk stratification for acute promyelocytic leukemia (APL)?

What is the efficacy of induction therapy in the treatment of acute promyelocytic leukemia (APL)?

What is the role of consolidation therapy in the treatment of acute promyelocytic leukemia (APL)?

What is the role of maintenance therapy in the treatment of acute promyelocytic leukemia (APL)?

How is relapsed or refractory acute promyelocytic leukemia (APL) treated?

What are the possible adverse effects of arsenic trioxide (ATO) in the treatment of acute promyelocytic leukemia (APL)?

What is the role of bone marrow transplantation in the treatment of acute promyelocytic leukemia (APL)?

What is the role of intrathecal chemotherapy in the treatment of acute promyelocytic leukemia (APL)?

How is acute promyelocytic leukemia (APL) treated in elderly patients?

Which activity modifications are used in the treatment of acute promyelocytic leukemia (APL)?

Which dietary modifications are used in the treatment of acute promyelocytic leukemia (APL)?

What are the possible complications of acute promyelocytic leukemia (APL)?

What are the signs and symptoms of differentiation syndrome caused by acute promyelocytic leukemia (APL) treatment?

How is differentiation syndrome prevented in acute promyelocytic leukemia (APL)?

How is differentiation syndrome treated in acute promyelocytic leukemia (APL)?

What are side effects of ATRA in the treatment of acute promyelocytic leukemia (APL)?

How is acute promyelocytic leukemia (APL) prevented?

Guidelines

Which organizations have issued guidelines on the diagnosis and treatment of acute promyelocytic leukemia (APL)?

What are the NCCN guidelines on the diagnosis of acute promyelocytic leukemia (APL)?

What are the NCCN guidelines on the treatment of low-risk acute promyelocytic leukemia (APL)?

What are the NCCN guidelines on the treatment of high-risk acute promyelocytic leukemia (APL)?

What are the NCCN guidelines on consolidation therapy for the treatment of acute promyelocytic leukemia (APL)?

Medications

What is the goal of drug treatment for acute promyelocytic leukemia (APL)?

Which medications in the drug class Antineoplastic Agents are used in the treatment of Acute Promyelocytic Leukemia?