History of the Procedure
Historically, surgical commissurotomy was the standard treatment for relief of mitral stenosis. The first single-balloon valvuloplasty of the mitral valve was described by Inoue et al in 1984. [1] Percutaneous mitral balloon valvuloplasty (PMBV) has since become the treatment of choice for mitral stenosis. The Inoue balloon catheter remains the most commonly used technique for percutaneous mitral balloon valvuloplasty.
Relevant Anatomy
The mitral valve apparatus consists of a fibrous mitral annulus and two mobile valve leaflets (anterior leaflet and posterior leaflet) tethered to the papillary muscles in the left ventricle by chordae tendineae. Blood flows across the valve from the left atrium into the ventricle during diastole. The normal mitral valve orifice size is 4-6 cm2. Commissural fusion of the mitral valve leaflets results in a decrease in mitral valve orifice size and an increase in left atrial pressures.
The anterior leaflet is located posterior to the aortic root and is also anchored to the aortic root, unlike the posterior leaflet. Accordingly, it is also known as the aortic, septal, greater, or anteromedial leaflet. The posterior leaflet is also known as the ventricular, mural, smaller, or posterolateral leaflet. The posterior leaflet is the section of the mitral valve that is located posterior to the two commissural areas. For more information about the relevant anatomy, see Mitral Valve Anatomy.
A transthoracic echocardiographic scoring system (see Imaging Studies section below) is used to evaluate the suitability of valve morphology for percutaneous mitral balloon valvuloplasty (PMBV). Other anatomic considerations in evaluating patients prior to PMBV include exclusion of left atrial thrombus and severe mitral regurgitation, both of which are contraindications to the procedure (see Contraindications section below).
Problem
Rheumatic mitral valve stenosis occurs as a result of rheumatic fever, usually decades after the acute illness. Commissural fusion of the mitral valve leaflets leads to obstruction of blood flow from the left atrium to the left ventricle. This obstruction, in turn, leads to chronically elevated pulmonary arterial pressures and symptoms of heart failure, especially with exercise or other conditions associated with tachycardia.
Pathophysiology
Commisural fusion of the mitral valve leaflets results in loss of the mitral orifice size. This limits blood flow across the valve from the left atrium to the left ventricle. Additionally, there is a loss of valvular reserve, the ability of the valve to open wider for larger blood flows, to facilitate an increase in cardiac output. Left atrial pressure is determined by the transvalvular gradient, which is a function of both orifice area and diastolic filling time. With exercise, heart rate and cardiac output increase, leading to an increase in left atrial and pulmonary arterial pressures.
Mitral orifice size correlates with severity of mitral stenosis and usually correlates with symptoms. The normal mitral valve area (MVA) measures 4-6 cm2. Mild reduction, with MVA measuring 2.0-2.5 cm2, results in elevated left atrial pressures when blood flow or heart rate is increased. Moderate reduction, with MVA 1.5-2.0 cm2, results in mildly elevated left atrial pressures at rest and significantly increased pressures with exercise. Severe mitral stenosis, at valve areas less than 1.5 cm2, results in reduced cardiac output and dyspnea at rest.
Etiology
Rheumatic mitral valve disease, manifested by commissural leaflet fusion, is the most common cause of mitral stenosis. Nonrheumatic mitral stenosis is unusual, although calcific stenosis is now seen with increasing frequency in hemodialysis patients. Other rare causes of mitral stenosis include carcinoid syndrome, eosinophilic endomyocardial fibroelastosis, and congenital mitral stenosis. These are distinctly different processes from rheumatic mitral stenosis without commissural fusion. Though limited, experience with balloon valvuloplasty for congenital mitral stenosis suggests little benefit from a potentially dangerous procedure. Surgery is usually preferable in these patients who often have associated complex anatomy. These patients should, therefore, be evaluated by a multidisciplinary team at an experienced center.
Epidemiology
Rheumatic heart disease remains uncommon in the United States. It is much more prevalent in developing nations, where patients tend to present at a younger age. The prevalence of rheumatic heart disease has, however, seen small but significant increases in recent decades as increasing numbers of immigrants enter the United States from endemic areas. Small recent outbreaks of rheumatic fever have also been reported in the United States by new virulent strains of streptococci.
Presentation
Note the following:
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The first complaints with mitral stenosis are usually of dyspnea on exertion.
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Early symptoms may be very subtle, and a history of rheumatic fever is often difficult to elicit.
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Patients are sometimes initially diagnosed with upper respiratory illness before re-evaluation prompts consideration for cardiovascular disease.
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In selected patients, formal exercise testing can help to elicit exercise-induced symptoms.
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Women with mitral stenosis frequently present during pregnancy when cardiac output and circulating intravascular volume increase.
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Physical examination may demonstrate a diastolic rumble or an opening snap.
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Chest radiography rarely shows pulmonary edema unless precipitated by an exacerbating illness; however, in advanced mitral stenosis, Kerley B lines from chronically elevated pulmonary venous pressures are sometimes visualized.
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Left atrial enlargement is typically present on the lateral chest radiograph.
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Left atrial enlargement is usually evident on the electrocardiogram.
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Atrial fibrillation often occurs in mitral stenosis as a result of left atrial dilatation and chronically elevated left atrial wall stress.
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Transthoracic echocardiography (TTE), the diagnostic test of choice, is usually necessary and sufficient to confirm the diagnosis of mitral stenosis.
Table 1. Mitral valve area and severity of mitral stenosis (Open Table in a new window)
MVA |
Severity |
Hemodynamic Effects |
4-6 cm2 |
Normal |
Normal left atrial (LA) pressure and cardiac output |
2-2.5 cm2 |
Mild |
LA pressure elevated only with increased blood flow or heart rate |
1.5-2.0 cm2 |
Moderate |
LA pressure mildly elevated at rest with significant increase during exercise |
< 1.5 cm2 |
Severe |
Reduced cardiac output and dyspnea at rest |
Indications
American Heart Association (AHA)/American College of Cardiology (ACC) guideline recommendations are as follows [2] :
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Perform percutaneous mitral balloon valvuloplasty (PMBV) for patients with severe mitral stenosis (mitral valve area [MVA] < 1.5 cm2), favorable valve morphology and absence of contraindications such as left atrial thrombus or significant mitral regurgitation (class I).
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Asymptomatic patients with MVA < 1.5 cm2, pulmonary hypertension (systolic pulmonary pressure >50 mmHg at rest or >60 mm Hg with exercise), and favorable valve morphology should also be considered for PMBV (class I).
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Patients with calcific mitral stenosis who are at high risk for surgical commissurotomy should be considered for PMBV when advanced heart failure (New York Heart Association [NYHA] class III-IV) and severe mitral stenosis (MVA < 1.5 cm2) are present (class IIa).
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Similar patients who are at lower risk for surgical commissurotomy may also be considered for PMBV (class IIb).
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Symptomatic patients (NYHA class II-IV) with milder stenosis (MVA >1.5 cm2) and pulmonary hypertension may be considered for PMBV (class IIb).
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Asymptomatic patients with MVA less than 1.5 cm2 with new atrial fibrillation may also be considered for PMBV (class IIb).
Similar recommendations have been made by the European Society of Cardiology. [3] Palliative treatment may be considered in patients who are not suitable candidates for surgery even when valve morphology is not ideal.
Table 2. Indications for percutaneous mitral balloon valvuloplasty - AHA/ACC guidelines (Open Table in a new window)
Class I |
NYHA class II-IV with MVA < 1.5 cm2, favorable valve morphology, absence of LA thrombus, absence of mod-severe |
|
Asymptomatic with MVA < 1.5 cm2 and PAP >50 mmHg at rest or >60 mmHg with exercise |
Class IIa |
NYHA Class III-IV, MVA < 1.5 cm2 calcified valve, high surgical risk |
Class IIb |
Asymptomatic with MVA < 1.5 cm2 new atrial fibrillation |
|
NYHA class II-IV MVA >1.5 cm2 and PAP >50 mmHg at rest or >60 mmHg with exercise |
|
NYHA class III-IV, MVA < 1.5 cm2 calcified valve, low surgical risk |
AHA/ACC = American Heart Association/American College of Cardiology; LA = left atrium; MVA = mitral valve area; NYHA = New York Heart Association; PAP = pulmonary artery pressure. |
Contraindications
The presence of left atrial thrombus is an absolute contraindication to percutaneous mitral balloon valvuloplasty (PMBV) because of the high risk for systemic embolism. Prior to proceeding with PMBV, all patients should be evaluated by transesophageal echocardiogram (TEE) with specific focus on the left atrial appendage to exclude thrombus. If left atrial thrombus is found, the patient should be treated with systemic anticoagulation for 3-6 months and undergo repeat TEE to confirm resolution of thrombus prior to PMBV. Patients with left atrial thrombus requiring more urgent therapy should be considered for surgical mitral valve replacement with ligation of the left atrial appendage.
Moderate to severe mitral regurgitation is also a contraindication to PMBV because of the risk of worsening regurgitation as a result of the procedure. Severe organic tricuspid stenosis and severe functional tricuspid regurgitation with an enlarged annulus are also relative contraindications to PMBV. Patients with severe concomitant aortic valve disease should be evaluated by an experienced multidisciplinary structural and/or valvular heart team to consider surgical versus transcatheter (ie. transcatheter aortic valve replacment [TAVR]) therapies.
Severe concomitant coronary artery disease requiring bypass surgery is a relative contraindication to PMBV. These patients should be considered for a combined coronary artery bypass and surgical mitral valve procedure. Patients considered high risk for cardiac surgery may still be considered for PMBV, especially if the coronary artery disease (CAD) can be treated percutaneously.
Unfavorable valve morphology is a relative contraindication to PMBV, although in selected patients, especially in those who are high surgical risk or in cases of palliation, PMBV can be considered.
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Mitral Valvuloplasty. The Inoue balloon catheter, seen here across the mitral valve, inflates in three stages. First, the distal portion of the balloon is inflated. The proximal portion of the balloon is then inflated, securing the position of the balloon across the mitral valve. Lastly, the middle portion of the balloon is inflated and partially splits the fused mitral valve leaflets. Note the catheter placed across the aortic valve into the left ventricle in addition to the transseptal balloon catheter.
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Mitral Valvuloplasty. These images are simultaneous tracings of pulmonary capillary wedge pressure and left ventricular pressure in a patient with mitral stenosis before valvuloplasty. The shaded area represents the gradient between the left atrium and the left ventricle. The mean gradient is 22 mmHg and the mitral valve area is 0.9 cm<sup>2</sup>.
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Mitral Valvuloplasty. Pulmonary capillary wedge pressure and left ventricular pressure in the same patient as in the previous image immediately after valvuloplasty. The mean gradient had decreased to 7 mmHg and the mitral valve area increased to 1.25 cm<sup>2</sup>.
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Mitral Valvuloplasty. Transthoracic echocardiogram (TTE) demonstrating severe mitral regurgitation with heavily calcified mitral valve and prolapse of the posterior leaflet into the left atrium.
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Mitral Valvuloplasty. Transesophageal echocardiogram (TTE) demonstrating prolapse of both mitral valve leaflets during systole.
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Mitral Valvuloplasty. Transthoracic echocardiogram (TTE) demonstrating bioprosthetic mitral valve dehiscence with paravalvular regurgitation.
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Mitral Valvuloplasty. Apical four-chamber echocardiographic view demonstrating restricted opening of the anterior and posterior mitral valve leaflet with diastolic doming of the anterior leaflet with left atrial enlargement.
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Mitral Valvuloplasty. Apical four-chamber view with color Doppler imaging demonstrating aliasing in the atrial side of the mitral valve consistent with increased gradient across the valve. This figure also shows mitral regurgitation and left atrial enlargement.
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Mitral Valvuloplasty. Magnified view of the mitral valve in the apical four-chamber view revealing restricted opening of both leaflets.
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Mitral Valvuloplasty. Transesophageal echocardiogram (TEE) in an apical three-chamber view showing calcification and doming of the anterior mitral leaflet and restricted opening of both leaflets.
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Mitral Valvuloplasty. Transesophageal echocardiogram (TEE) in an apical three-chamber view with color Doppler interrogation of the mitral valve revealing aliasing, which is consistent with an increased gradient across the mitral valve secondary to stenosis. Also shown in this image, a posteriorly directed jet of severe mitral regurgitation.