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Sections Intrahepatic Cholestasis of Pregnancy
- Overview
- Presentation
- DDx
- Workup
- Treatment
- Medication
- Follow-up
- Questions & Answers
- References
History
Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus that usually occurs in the second or third trimester; however, ICP may occur as early as the first trimester. ICP-related pruritus without a rash may affect all areas of the body but characteristically starts in the soles of the feet and palms of the hands and progresses to the trunk and face. [44] Pruritus associated with ICP is often worse at night and the pruritus may be so severe that it can affect the patient’s quality of life, even leading to suicidal ideation. [16] Steatorrhea and vitamin K deficiency may also occur due to fat malabsorption. [44] If the vitamin K deficiency is not corrected by the time of delivery, a postpartum hemorrhage may ensue.
Physical
ICP is characterized by profound itching often beginning with the palms of the hands and soles of the feet without evidence of a rash.
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Tables
Fidelma B Rigby, MD Associate Professor, Department of Obstetrics and Gynecology, Section of Maternal-Fetal Medicine, Virginia Commonwealth University Medical Center
Fidelma B Rigby, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.
Stacey Ehrenberg-Buchner, MD Fellow in Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan Health System
Stacey Ehrenberg-Buchner, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Ronald M Ramus, MD Professor of Obstetrics and Gynecology, Director, Division of Maternal-Fetal Medicine, Virginia Commonwealth University School of Medicine
Ronald M Ramus, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Institute of Ultrasound in Medicine, Medical Society of Virginia, Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.
Suzanne R Trupin, MD, FACOG Clinical Professor, Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Urbana-Champaign; CEO and Owner, Women's Health Practice; CEO and Owner, Hada Cosmetic Medicine and Midwest Surgical Center
Suzanne R Trupin, MD, FACOG is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Institute of Ultrasound in Medicine, International Society for Clinical Densitometry, AAGL, North American Menopause Society, American Medical Association, Association of Reproductive Health Professionals
Disclosure: Nothing to disclose.
George A VanBuren, MD Assistant Professor, Department of Reproductive Biology, Case Western Reserve University School of Medicine
George A VanBuren, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists
Disclosure: Nothing to disclose.
What would you like to print?
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Sections Intrahepatic Cholestasis of Pregnancy
- Overview
- Presentation
- DDx
- Workup
- Treatment
- Medication
- Follow-up
- Questions & Answers
- References
