Intrahepatic Cholestasis of Pregnancy Questions & Answers

Updated: Jan 14, 2019
  • Author: Fidelma B Rigby, MD; Chief Editor: Ronald M Ramus, MD  more...
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Questions & Answers

Overview

What is intrahepatic cholestasis of pregnancy (ICP)?

What is the prevalence of intrahepatic cholestasis of pregnancy (CIP)?

What is the pathophysiology of intrahepatic cholestasis of pregnancy (CIP)?

What is the role of estrogen in the pathophysiology of intrahepatic cholestasis of pregnancy (CIP)?

What is the role of environmental factors in the pathophysiology of intrahepatic cholestasis of pregnancy (CIP)?

What is the role of bile acids in the pathophysiology of intrahepatic cholestasis of pregnancy (CIP)?

What is a prognostic indicator of intrahepatic cholestasis of pregnancy (CIP)?

What is the incidence of intrahepatic cholestasis of pregnancy (CIP) in the US?

Why is early delivery considered in women with intrahepatic cholestasis of pregnancy (CIP)?

What is the risk for fetal death from intrahepatic cholestasis of pregnancy (CIP)?

What are the indications of intrauterine fetal demise from intrahepatic cholestasis of pregnancy (CIP)?

Presentation

Which clinical history is characteristic of intrahepatic cholestasis of pregnancy (CIP)?

Which physical findings are characteristic of intrahepatic cholestasis of pregnancy (CIP)?

DDX

What are the differential diagnoses for Intrahepatic Cholestasis of Pregnancy?

Workup

What is the role of lab studies in the workup of intrahepatic cholestasis of pregnancy (CIP)?

What is the role of total bilirubin levels in the workup of intrahepatic cholestasis of pregnancy (CIP)?

What are the recommended lab studies for the diagnosis of intrahepatic cholestasis of pregnancy (CIP)?

How is intrahepatic cholestasis of pregnancy (CIP) diagnosed?

What is the role of liver biopsy in the workup of intrahepatic cholestasis of pregnancy (CIP)?

How is intrahepatic cholestasis of pregnancy (CIP) differentiated from other pruritic disorders?

Treatment

What measures are taken to reduce the risk of stillbirth in patients with intrahepatic cholestasis of pregnancy (CIP)?

When is delivery recommended in patients with intrahepatic cholestasis of pregnancy (CIP)?

What is reported outcomes for women with intrahepatic cholestasis of pregnancy (CIP) treated with ursodeoxycholic acid?

Medications

Which medications are used in the treatment of intrahepatic cholestasis of pregnancy (CIP)?

What is the role of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (CIP?

What is the role of antihistamines in the treatment of intrahepatic cholestasis of pregnancy (CIP)?

Follow-up

How are women with intrahepatic cholestasis of pregnancy (CIP) monitored prior to delivery?

What is the recurrence rate for intrahepatic cholestasis of pregnancy (CIP)?

What is the role of oral contraceptive pills (OCP) in the recurrence of intrahepatic cholestasis of pregnancy (CIP)?

How are women with intrahepatic cholestasis of pregnancy (CIP) monitored following delivery?

What are the complications of intrahepatic cholestasis of pregnancy (CIP)?