Hemorrhoids result from disruption of the anchoring of the anal cushions. They occur most commonly in the right anterior position and are associated with straining and irregular bowel habits. During defecation, straining engorges the cushions, resulting in their displacement. Repetition of this displacement results in stretching and eventual prolapse of the anal cushions, known as hemorrhoids (see the image below).
Constipation and all conditions that result in abnormal anal pressure and compliance predispose to the formation of hemorrhoids. Acquired conditions such as portal hypertension cause engorgement of these venous plexuses, which can also contribute to anal cushion displacement. Pregnancy can also cause or aggravate symptoms; direct pressure may play a role, but other factors (eg, hormonal fluctuations) may contribute.
Inflammatory bowel disease (IBD) and consistent diarrhea can cause hemorrhoidal disease. Any patient with a combination of hemorrhoidal and IBD should be viewed with caution.[1]
Hemorrhoids may be broadly classified as either external or internal. External hemorrhoids are located distal to the dentate line and cause pain when they thrombose. This area is covered with sensate squamous epithelium, and thus, the patient typically reports pain, swelling, itching, or a combination of these symptoms.
Internal hemorrhoids are located proximal to the dentate line. This area is composed of insensate columnar-glandular epithelium. Internal hemorrhoids bleed, prolapse, or both. Patients typically present with sudden painless bleeding, usually after a bowel movement. Patients should undergo anoscopic examination or colonoscopy to rule out malignancy or diverticular disease.
Internal hemorrhoids may be graded as follows:
Depending on the severity of the symptoms, hemorrhoids are managed either medically or surgically.
The 2010 practice parameters published by the American Society of Colon and Rectal Surgeons (ASCRS) provide recommendations for evaluating patients with hemorrhoids, for identifying patients who require endoscopic evaluation of the colon, and for treatment options such as diet modification, office-based procedures, and surgical hemorrhoidectomy.[2]
In general, the treatment options vary by hemorrhoid severity or grade. For example, office-based procedures are reserved for patients with grades I, II, and III hemorrhoids and who have failed medical management. Surgical treatment of hemorrhoid disease is customarily offered for patients whose disease does not respond to or who are not able to tolerate office-based procedures, as well as for patients with large external hemorrhoids or grade III/IV combined internal/external hemorrhoids.
For grade I and II hemorrhoids, medical treatment is indicated as first-line management. Medical treatment consists of dietary changes and bulk-forming agents. Dietary management is the first line of therapy. Patients are advised to ingest adequate fiber and water and avoid straining. This conservative management is effective for hemorrhoids with lesser degrees of prolapse.[3, 4]
For grade I and II hemorrhoids—as well as some prolapsed grade II hemorrhoids and some grade III hemorrhoids—and for cases in which medical management is not adequate, an office procedure may be indicated. Such procedures include the following:
Surgery is reserved for cases in which conservative management is not adequate—for instance, hemorrhoids refractory to office procedures, large external hemorrhoids, hemorrhoids with significant bleeding, and prolapsed internal hemorrhoids. The following surgical procedures may be indicated, with excisional hemorrhoidectomy being the gold standard:
Contraindications for office treatments include the following:
Hemorrhoidal cushions are anal cushions of tissue composed of blood vessels, smooth muscle, and connective tissue. These cushions are located in the upper anal canal at three different sites: left lateral, right anterolateral, and right posterolateral. They are separate structures rather than a continuous ring of vascular tissue and therefore allow the anal canal to dilate during defecation without tearing.
Anal cushions are thought to aid in anal continence, though their function is not entirely understood. During the act of defecation, the anal cushions become engorged and tense with blood, cushioning the anal canal lining.
The anal canal above the dentate line is supplied by the terminal branches of the superior rectal (hemorrhoidal) artery, which is the terminal branch of the inferior mesenteric artery. The middle rectal artery (a branch of the internal iliac artery) and the inferior rectal artery (a branch of the internal pudendal artery) supply the lower anal canal. For more information about the relevant anatomy, see Anal Canal Anatomy.
Xu et al carried out a meta-analysis of five randomized, controlled trials with the aim of evaluating the outcomes of LigaSure (Covidien, Minneapolis, MN) hemorrhoidectomy against those of Ferguson hemorrhoidectomy.[5] In the 318 patients who met the inclusion criteria, LigaSure hemorrhoidectomy was associated with lower urinary retention rates, lower early postoperative pain scores, shorter operating times, shorter hospital stays, and less intraoperative blood loss.
De Nardi et al performed a prospective randomized trial to assess the short- and long-term results of Doppler-guided transanal hemorrhoid dearterialization with mucopexy against those of excision hemorrhoidectomy in patients with grade III hemorrhoids.[6] They found the two approaches to be similar with respect to postoperative pain, postoperative morbidity, and long-term cure rate.
Trenti et al, in a single-center longitudinal study evaluating Doppler-guided transanal hemorrhoidal dearterialization with mucopexy against conventional excisional hemorrhoidectomy for grade III-IV hemorrhoids, found that the former was not inferior to the latter with regard to postoperative complications and long-term recurrence of symptoms.[7] The overall rate of urinary retention and postoperative hemorrhoid thrombosis was higher in the HAL group, though the difference was not statistically significant.
A 2006 Cochrane review examined differences in outcomes between stapled hemorrhoidopexy and conventional excisional hemorrhoidectomy.[8] The study showed significant increases in the recurrence rate and the need for additional procedures in the stapled hemorrhoidopexy group.
For all treatments, a conventional anal retractor (eg, a Parks or Fansler retractor) is required. For hemorrhoidectomy, the following additional equipment is required:
For office treatments, local anesthesia is used. For surgical treatments, general anesthesia or local anesthesia combined with mild sedation may be used. No matter what type of anesthesia is employed, the procedure begins with local injection of the entire anal canal with bupivacaine or lidocaine with epinephrine.
For both office and surgical treatments, place the patient in a jack-knife prone, lithotomy, or left lateral decubitus position.
The procedure is performed through an anoscope with a rubber band ligator. Using a Lurz-Goltner suction hemorrhoidal ligator, draw the hemorrhoid mass into the cup with suction. The most prominent hemorrhoid with acute stigmata of bleeding is treated first. Place the band on the rectal mucosa at the base of the internal hemorrhoid (see the image below). Ensure that the patient has no feeling of pain. Perform ligation one site at a time. Band consecutive hemorrhoids in a similar fashion, going from largest to smallest.
The patient rarely experiences pain during the procedure. If the patient does experience pain, the band must be removed immediately. Conventional suture-removal scissors can be inserted to cut the band from the hemorrhoids. Other methods of cutting the band can be used, such as a scalpel, but this tends to precipitate bleeding.
An infrared photocoagulator produces infrared radiation, coagulates tissue protein, and evaporates water in the cells. The advantage of infrared coagulation is that the physician may treat one area at a time or ablate all hemorrhoidal areas.
Infiltrate the area with 2-5 mL of 0.5% bupivacaine. The area to be treated can be visually determined; adjust the dosing of the local anesthetic accordingly.
Apply an infrared probe just proximal to the internal hemorrhoids through an anoscope. The standard recommendation is to apply the probe for 1.5 seconds and repeat the application three times on each internal hemorrhoid.[9, 10, 11, 12, 13, 14] The radiation causes protein coagulation in an area 3 mm wide and 3 mm deep, for a use of three to five pulses.
After the coagulation, the tissue appears white and circular in nature. It progresses to a darker color over the following week. Eventually, a slightly elevated, pink-red eschar results.
Bipolar electrocoagulation is similar to infrared photocoagulation. It is simple to use and is typically done as an outpatient procedure. No anesthesia is typically required. However, this procedure is typically time-consuming and is not as popular as other treatment options.[15, 16, 17, 18]
Using the anoscope, apply the side of the probe tip directly to the hemorrhoid, above the dentate line (see the image below). Use the infinity setting on the electrode generator. This is activated by the physician with a foot switch. A white coagulum stream is generated that is approximately 3 mm deep. Set the current to a maximal tolerable level and continue for 10 minutes. All hemorrhoids are typically treated in a single session.
Sclerotherapy involves the injection of chemical agents into the hemorrhoids to create fibrosis and prevent prolapse. The solutions used are phenol in oil, quinine urea, and sodium morrhuate. Sclerotherapy used to be the treatment of choice for grade I, II, and III hemorrhoids. It has been used with rubber band ligation with increased success rates.[19, 20, 21, 22, 23, 24, 25, 26]
Attach a 10-mL syringe to a standard-sized 25-gauge angled hemorrhoid needle. Introduce the needle into the center mass of veins, through the mucous membrane. Take care not to enter the lumen of the vein or traverse the sensitive margin of the dentate line. To ensure that the needle does not enter the lumen, draw it back before injecting. No antiseptic is necessary.
When the needle is in position, inject 0.5 mL of the sodium morrhuate or 5% phenol solution into the submucosa above the internal hemorrhoid, at the anorectal ring. Do not inject intravascularly. If the sodium morrhuate solution is used, the total amount injected should be no more than 3 mL. If the 5% phenol solution is used, up to 3 mL can be injected into each site.
Cryotherapy uses a special probe that uses nitrous oxide to freeze the hemorrhoid. The temperature of the probe can get as low as –196˚C with liquid nitrogen. Cryotherapy was once advocated by many surgeons for the treatment of hemorrhoids and was associated with the least amount of pain.
Insert and manipulate the fingers, a modified plastic proctoscope, or a vaginal speculum so as to isolate one primary hemorrhoidal plexus at a time. A metal instrument is not recommended, because it conducts cold, and the procedure is reliant on a water-soluble jelly that is used for contact between the probe and the hemorrhoid.
Apply the cryoprobe so that the tissue freezes around the tip. The distance between the tip and the outer portion of the probe is equal to the depth of the probe. This allows the surgeon to visually determine how much tissue is being destroyed. Changes that occur in the margin of space between the tip of the probe and the normal tissue are reversible; theoretically, therefore, no destruction has taken place.
Considerable edema can result within 24 hours after the procedure. This swelling does not interfere with the patient’s ability to have a normal bowel movement.
Drainage of the area from the degradation and breakdown of tissue begins several hours after the procedure. It starts out fairly heavy for the first 3-4 days and decreases over the next 2-3 weeks. Instruct patients to use a clean or sterile pad, changed several times a day, for the first 3-4 days. This aids in the prevention of infection.
By postoperative day 5 or 6, the hemorrhoid appears pale and black. Gangrenous areas may appear, but the necrosis is typically complete by postoperative day 7-9. By postoperative day 18, the area disintegrates completely, leaving a normal-appearing anus.
Hemorrhoidectomy allows full-thickness excision of mucosa and submucosa without injury to the underlying sphincter muscle. If, at the end of the procedure, the mucosa is closed with an absorbable suture, the procedure is a closed hemorrhoidectomy (see the first image below); if the mucosa is left open, the procedure is an open hemorrhoidectomy (see the second image below). Because of its relatively low recurrence rate, excisional hemorrhoidectomy remains the gold standard treatment.
Make an elliptical incision at the perianal skin, and continue it to the anorectal ring in a vertical fashion. The incision should include the internal and external hemorrhoids. At all times, ensure that the submucosa is lifted from the underlying sphincter complex without injury to the muscles. The resection can be performed with a surgical scalpel, a diathermy, a laser, or an ultrasonic scalpel.[27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38]
Patients are typically sore for as long as 3-10 days after surgery. For pain control, prescribe oral narcotics and, if necessary, a topical anesthetic cream.
Doppler-guided hemorrhoidal artery ligation (HAL),[39, 40] a procedure first described in 1995, involves the use of a proctoscope that allows the insertion of a Doppler transducer through it.
There are, on average, eight hemorrhoidal arteries (all branches of the superior hemorrhoidal artery) that are located in the submucosa within 2 cm of the dentate line. These arterial branches are identified by means of the Doppler device and ligated with an absorbable suture. In the case of grade III or IV hemorrhoids, a mucopexy is also performed to prevent prolapse.[41] This procedure is typically performed in the operating room with the patient under either general or locoregional anesthesia. (See the image below.)
In a stapled hemorrhoidopexy, a modified circular stapler resects the excess prolapsed hemorrhoidal tissue and fixes the rest of hemorrhoidal tissue to the distal rectal wall (see the image below).
Insert a circular anal dilator, and anchor it to the skin with a heavy suture on a cutting needle. Apply countertraction to the skin to facilitate insertion.
Introduce the purse-string suture anoscope through the circular anal dilator. The rotation effect of the suture anoscope allows the placement of a purse-string suture in a circular fashion at the correct height (3-4 cm above the dentate line) and depth (mucosa and submucosa). Place small bites close together with a 2-0 monofilament suture on a 25-30 mm curved needle. No “dog-ears” or gaps should be present.
Insert the fully open stapler head through the purse-string, and throw one knot on the purse-string. Then, draw back the two tails of the suture through the lateral channels in the head of the anvil. Further secure the purse-string under direct visualization. Knot the tails or clamp them with forceps.
Align the stapler along the axis of the anal canal and close it while maintaining downward tension with the lateral tails. The 4 cm mark should be at the level of the anal verge. If the patient is female, pass a finger into the vagina to ensure the posterior wall is not caught in the stapler. Fire the stapler, then open the head and remove the stapler. Inspect the staple line for bleeding and reinforce the staples, if needed.
Multiple studies have shown that in comparison with open or closed hemorrhoidectomy, stapled hemorrhoidopexy results in less pain and faster return to normal activity.[42, 43, 44] Some authors suggest that stapled hemorrhoidopexy presents an increased risk of septic complications (eg, rectal perforation, pelvic sepsis, persistent severe pain and fecal urgency, rectal stricture, rectal obstruction, and rectovaginal fistula). There is no evidence to suggest that prophylactic antibiotics are appropriate or helpful. Because of its high recurrence rates, stapled hemorrhoidopexy is not performed at the authors’ institution; excisional hemorrhoidectomy is preferred.
Partial stapled hemorrhoidopexy has been suggested as a viable alternative to circular stapled hemorrhoidopexy for some patients with grade III-IV proplapsing hemorrhoids.[45] In this procedure, only the mucosa and submucosa overlying the hemorrhoidal columns are included, so as to create a partial purse-string rather than a circumferential purse-string. In theory, using fewer staples could lead to less inflammation and possibly decreased postoperative pain, tenesmus, incontinence, and fistula risk. At present, however, the available long-term data are insufficient for full evaluation of these outcomes.[45, 46, 47]
Complications of rubber band ligation may include the following:
No additional complications are associated with doing more than one rubber band ligation of more than one site, and this approach can be more cost-effective.[48, 49, 50, 51, 52, 53, 54, 55]
Complications of cryotherapy may include the following:
Complications of other office treatments may include the following:
Complications of hemorrhoidectomy may include the following[27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37] :
Complications of stapled hemorrhoidopexy include the aforementioned complciations, as well as the following:
A complication specific to HAL is hemorrhoid thrombosis. This is often treated with thrombectomy for pain relief.[7]