Wolff-Parkinson-White Syndrome Questions & Answers

1. Wolff L, Parkinson J, White PD. Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. Am Heart J. 1930 Aug. 5(6):685-704. [Full Text].

2. Gollob MH, Green MS, Tang AS, et al. Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med. 2001 Jun 14. 344(24):1823-31. [QxMD MEDLINE Link].

3. Calkins H, Kuck KH, Cappato R, et al, for the Heart Rhythm Society Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology ... Heart Rhythm. 2012 Apr. 9 (4):632-696.e21. [QxMD MEDLINE Link].

4. Calkins H, Sousa J, el-Atassi R, et al. Diagnosis and cure of the Wolff-Parkinson-White syndrome or paroxysmal supraventricular tachycardias during a single electrophysiologic test. N Engl J Med. 1991 Jun 6. 324(23):1612-8. [QxMD MEDLINE Link].

5. Sarubbi B, D'Alto M, Vergara P, et al. Electrophysiological evaluation of asymptomatic ventricular pre-excitation in children and adolescents. Int J Cardiol. 2005 Feb 15. 98(2):207-14. [QxMD MEDLINE Link].

6. Durrer D, Schuilenburg RM, Wellens HJ. Pre-excitation revisited. Am J Cardiol. 1970 Jun. 25(6):690-7. [QxMD MEDLINE Link].

7. Pappone C, Vicedomini G, Manguso F, et al. Risk of malignant arrhythmias in initially symptomatic patients with Wolff-Parkinson-White syndrome: results of a prospective long-term electrophysiological follow-up study. Circulation. 2012 Feb 7. 125(5):661-8. [QxMD MEDLINE Link].

8. Pappone C, Santinelli V, Manguso F, et al. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome. N Engl J Med. 2003 Nov 6. 349(19):1803-11. [QxMD MEDLINE Link].

9. Sethi KK, Dhall A, Chadha DS, Garg S, Malani SK, Mathew OP. WPW and preexcitation syndromes. J Assoc Physicians India. 2007 Apr. 55 Suppl:10-5. [QxMD MEDLINE Link].

10. Katritsis DG, Camm AJ. Atrioventricular nodal reentrant tachycardia. Circulation. 2010 Aug 24. 122 (8):831-40. [QxMD MEDLINE Link].

11. Stroobandt RX, Barold SS, Sinnaeve AF. Preexcitation and Wolff-Parkinson-White Syndrome (WPW). ECG from Basics to Essentials: Step by Step. Chichester, West Sussex, UK: John Wiley & Sons, Ltd; 2016. chapter 17.

12. Khairy P, Van Hare GF, Balaji S, Berul CI, Cecchin F, Cohen MI, et al. PACES/HRS Expert Consensus Statement on the Recognition and Management of Arrhythmias in Adult Congenital Heart Disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Societ... Heart Rhythm. 2014 Oct. 11 (10):e102-65. [QxMD MEDLINE Link].

13. Ehtisham J, Watkins H. Is Wolff-Parkinson-White syndrome a genetic disease?. J Cardiovasc Electrophysiol. 2005 Nov. 16(11):1258-62. [QxMD MEDLINE Link].

14. Bowles NE, Jou CJ, Arrington CB, et al for the Baylor Hopkins Centers for Mendelian Genomics. Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. Am J Med Genet A. 2015 Aug 18. [QxMD MEDLINE Link].

15. Brembilla-Perrot B, Yangni N'da O, Huttin O, et al. Wolff-Parkinson-White syndrome in the elderly: clinical and electrophysiological findings. Arch Cardiovasc Dis. 2008 Jan. 101(1):18-22. [QxMD MEDLINE Link].

16. Pappone C, Santinelli V. Electrophysiology testing and catheter ablation are helpful when evaluating asymptomatic patients with Wolff-Parkinson-White pattern: the pro perspective. Card Electrophysiol Clin. 2015 Sep. 7 (3):371-6. [QxMD MEDLINE Link].

17. Cohen MI, Triedman JK, Cannon BC, et al. PACES/HRS expert consensus statement on the management of the asymptomatic young patient with a Wolff-Parkinson-White (WPW, ventricular preexcitation) electrocardiographic pattern: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology Foundation (ACCF), the American Heart Association (AHA), the American Academy of Pediatrics (AAP), an... Heart Rhythm. 2012 Jun. 9 (6):1006-24. [QxMD MEDLINE Link].

18. Zhang Y, Wang L. Atrial vulnerability is a major mechanism of paroxysmal atrial fibrillation in patients with Wolff-Parkinson-White syndrome. Med Hypotheses. 2006. 67(6):1345-7. [QxMD MEDLINE Link].

19. Deneke T, Mügge A. Atrial fibrillation and Wolff-Parkinson-White syndrome: mechanisms revisited?. J Cardiovasc Electrophysiol. 2012 Mar. 23 (3):287-9. [QxMD MEDLINE Link].

20. Bunch TJ, May HT, Bair TL, et al. Long-term natural history of adult Wolff-Parkinson-White syndrome patients treated with and without catheter ablation. Circ Arrhythm Electrophysiol. 2015 Oct 19. [QxMD MEDLINE Link].

21. Szumowski L, Walczak F, Urbanek P, et al. Risk factors of atrial fibrillation in patients with Wolff-Parkinson-White syndrome. Kardiol Pol. 2004 Mar. 60(3):206-16; discussion 217. [QxMD MEDLINE Link].

22. Bromberg BI, Lindsay BD, Cain ME, Cox JL. Impact of clinical history and electrophysiologic characterization of accessory pathways on management strategies to reduce sudden death among children with Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 1996 Mar 1. 27(3):690-5. [QxMD MEDLINE Link].

23. Attoyan C, Haissaguerre M, Dartigues JF, Le Metayer P, Warin JF, Clementy J. [Ventricular fibrillation in Wolff-Parkinson-White syndrome. Predictive factors]. Arch Mal Coeur Vaiss. 1994 Jul. 87(7):889-97. [QxMD MEDLINE Link].

24. Kiger ME, McCanta AC, Tong S, Schaffer M, Runciman M, Collins KK. Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. Pacing Clin Electrophysiol. 2015 Aug 8. [QxMD MEDLINE Link].

25. Shah A, Hocini M, Haissaguerre M, Jais P. Non-invasive mapping of cardiac arrhythmias. Curr Cardiol Rep. 2015 Aug. 17 (8):60. [QxMD MEDLINE Link].

26. Mark DG, Brady WJ, Pines JM. Preexcitation syndromes: diagnostic consideration in the ED. Am J Emerg Med. 2009 Sep. 27(7):878-88. [QxMD MEDLINE Link].

27. Fengler BT, Brady WJ, Plautz CU. Atrial fibrillation in the Wolff-Parkinson-White syndrome: ECG recognition and treatment in the ED. Am J Emerg Med. 2007 Jun. 25(5):576-83. [QxMD MEDLINE Link].

28. Arruda MS, McClelland JH, Wang X, et al. Development and validation of an ECG algorithm for identifying accessory pathway ablation site in Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 1998 Jan. 9(1):2-12. [QxMD MEDLINE Link].

29. Burnes JE, Taccardi B, Rudy Y. A noninvasive imaging modality for cardiac arrhythmias. Circulation. 2000 Oct 24. 102(17):2152-8. [QxMD MEDLINE Link]. [Full Text].

30. Ghosh S, Avari JN, Rhee EK, Woodard PK, Rudy Y. Hypertrophic cardiomyopathy with preexcitation: insights from noninvasive electrocardiographic imaging (ECGI) and catheter mapping. J Cardiovasc Electrophysiol. 2008 Nov. 19(11):1215-7. [QxMD MEDLINE Link]. [Full Text].

31. Skanes AC, Obeyesekere M, Klein GJ. Electrophysiology testing and catheter ablation are helpful when evaluating asymptomatic patients with Wolff-Parkinson-White pattern: the con perspective. Card Electrophysiol Clin. 2015 Sep. 7 (3):377-83. [QxMD MEDLINE Link].

32. Duszanska A, Lenarczyk R, Kowalski O, Streb W, Kukulski T, Kalarus Z. Evaluation of left ventricular systolic and diastolic function in patients with atrioventricular re-entrant tachycardia treated by radiofrequency current ablation. Acta Cardiol. 2008 Apr. 63(2):221-7. [QxMD MEDLINE Link].

33. Jackman WM, Wang XZ, Friday KJ, et al. Catheter ablation of accessory atrioventricular pathways (Wolff- Parkinson-White syndrome) by radiofrequency current. N Engl J Med. 1991 Jun 6. 324(23):1605-11. [QxMD MEDLINE Link].

34. Pappone C, Radinovic A, Santinelli V. Sudden death and ventricular preexcitation: is it necessary to treat the asymptomatic patients?. Curr Pharm Des. 2008. 14(8):762-5. [QxMD MEDLINE Link].

35. Capone CA, Ceresnak SR, Nappo L, Gates GJ, Schechter CB, Pass RH. Three-catheter technique for ablation of left-sided accessory pathways in Wolff-Parkinson-White is less expensive and equally successful when compared to a five-catheter technique. Pacing Clin Electrophysiol. 2015 Aug 27. [QxMD MEDLINE Link].

36. [Guideline] January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014 Dec 2. 130 (23):e199-267. [QxMD MEDLINE Link]. [Full Text].

37. [Guideline] Page RL, Joglar JA, Caldwell MA, Calkins H, Conti JB, Deal BJ, et al. 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2016 Apr 5. 133 (14):e506-74. [QxMD MEDLINE Link]. [Full Text].

38. [Guideline] Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015 Nov 1. 36 (41):2793-867. [QxMD MEDLINE Link]. [Full Text].

39. Pappone C, Manguso F, Santinelli R, et al. Radiofrequency ablation in children with asymptomatic Wolff-Parkinson-White syndrome. N Engl J Med. 2004 Sep 16. 351(12):1197-205. [QxMD MEDLINE Link].

Christopher R Ellis, MD, FACC, FHRS Assistant Professor of Medicine, Cardiac Electrophysiology, Director of Clinical Arrhythmia Research, Vanderbilt Heart and Vascular Institute

Christopher R Ellis, MD, FACC, FHRS is a member of the following medical societies: Alpha Omega Alpha, American College of Cardiology, Heart Rhythm Society

Disclosure: Nothing to disclose.

Mikhael F El-Chami, MD Associate Professor, Department of Medicine, Division of Cardiology, Section of Electrophysiology, Emory University School of Medicine

Mikhael F El-Chami, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Cardiology, American Heart Association, Heart Rhythm Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Medtronic; Boston Scientific, Biotronik<br/>Received research grants (as part of Multicenter studies) from Medtronic and Boston Scientific.

Hugh D Allen, MD Professor, Department of Pediatrics, Division of Pediatric Cardiology and Department of Internal Medicine, Ohio State University College of Medicine

Hugh D Allen, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American Heart Association, American Pediatric Society, American Society of Echocardiography, Society for Pediatric Research, Society of Pediatric Echocardiography, and Western Society for Pediatric Research

Disclosure: Nothing to disclose.

Stuart Berger, MD Professor of Pediatrics, Division of Cardiology, Medical College of Wisconsin; Chief of Pediatric Cardiology, Medical Director of Pediatric Heart Transplant Program, Medical Director of The Heart Center, Children's Hospital of Wisconsin

Stuart Berger, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American College of Chest Physicians, American Heart Association, and Society for Cardiac Angiography and Interventions

Disclosure: Nothing to disclose.

M Silvana Horenstein, MD Assistant Professor, Department of Pediatrics, University of Texas Medical School at Houston; Medical Doctor Consultant, Legacy Department, Best Doctors, Inc

M Silvana Horenstein, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, and American Medical Association

Disclosure: Nothing to disclose.

Russell F Kelly MD, Assistant Professor, Department of Internal Medicine, Rush Medical College; Chairman of Adult Cardiology and Director of the Fellowship Program, Cook County Hospital

Russell F Kelly is a member of the following medical societies: American College of Cardiology

Disclosure: Nothing to disclose.

Brian Olshansky, MD Professor Emeritus of Medicine, Department of Internal Medicine, University of Iowa College of Medicine

Brian Olshansky, MD is a member of the following medical societies: American College of Cardiology, American Heart Association, Cardiac Electrophysiology Society, and Heart Rhythm Society

Disclosure: Guidant/Boston Scientific Honoraria Speaking and teaching; Medtronic Honoraria Speaking and teaching; Guidant/Boston Scientific Consulting fee Consulting; BioControl Consulting fee Consulting; Boehringer Ingelheim Consulting fee Consulting; Amarin Consulting fee Review panel membership; sanofi aventis Review panel membership

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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