Lown-Ganong-Levine Syndrome Clinical Presentation

Updated: Dec 09, 2020
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jose M Dizon, MD  more...
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History and Physical Examination


Symptoms of paroxysmal tachycardia must be elicited, although they may be asymptomatic. [1] Manifestations of such paroxysms include palpitations, lightheadedness, and shortness of breath. In cases of underlying structural heart disease or coronary artery disease, episodes of tachycardia may induce cardiac stress and produce symptoms of chest pain or possibly of hypotension or other hemodynamic instability. At higher ventricular rates, syncope may occur, particularly if ventricular tachycardia or ventricular fibrillation are initiated.

Physical examination

An accentuated first heart sound of mitral valve closure may be present in 87% of cases. [4]  During paroxysms of tachycardia, cardiovascular examination may reveal a rapid heart rate. Absence of a rapid heart rate does not exclude LGL as a possible diagnosis, as the tachycardia of LGL is paroxysmal.