Multiple Minute Digitate Hyperkeratoses Treatment & Management

Updated: Jun 19, 2018
  • Author: Annie Wester, MD, MS; Chief Editor: Dirk M Elston, MD  more...
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Treatment

Medical Care

No large studies on treatment options for minute digitate hyperkeratosis (MMDH) (spiny hyperkeratosis) have been performed. Improvement in minute digitate hyperkeratosis (spiny hyperkeratosis) has been reported with treatment using the following agents:

  • Topical keratolytics combined with topical emollients

  • Tretinoin cream and oral vitamin A

  • Topical 5-fluorouracil cream

Resolution without treatment has also been reported. [19]

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Surgical Care

The lesions of minute digitate hyperkeratosis (spiny hyperkeratosis) can be trimmed or clipped as needed.

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Diet

Nutrition is an important consideration when evaluating keratinization disorders. A review of nutritional status should be performed.

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Long-Term Monitoring

Follow patients on a yearly basis because of the rarity of minute digitate hyperkeratosis (spiny hyperkeratosis). In particular, an annual skin examination and follow up by a primary care physician for age-appropriate screenings are recommended.

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