Brugada Syndrome Differential Diagnoses

Updated: Apr 03, 2020
  • Author: Jose M Dizon, MD; Chief Editor: Mikhael F El-Chami, MD  more...
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Diagnostic Considerations

The differential diagnosis of cardiac arrest in an otherwise presumably healthy subject is varied, but it includes such entities as acute cardiac ischemia due to atherosclerosis or coronary anomaly, hypertrophic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, long QT syndrome, and arrhythmogenic right ventricular cardiomyopathy (ARVC). Many of these entities can be differentiated on the basis of history and physical examination. Occasionally, however, there is overlap that requires special consideration.

The differential diagnosis of right precordial ST-segment elevation is as follows [18, 29] :

  • Atypical right bundle-branch block
  • Left ventricular hypertrophy
  • Early repolarization
  • Acute pericarditis
  • Acute myocardial ischemia or infarction
  • Prinzmetal angina
  • Pulmonary embolism
  • Dissecting aortic aneurysm
  • Mediastinal tumor or hemopericardium compressing the right ventricular outflow tract
  • Arrhythmogenic right ventricular dysplasia and/or cardiomyopathy
  • Various abnormalities of the central and autonomic nervous systems
  • Overdose of a heterocyclic antidepressant
  • Cocaine intoxication
  • Duchenne muscular dystrophy
  • Friedreich ataxia
  • Thiamine deficiency Hypercalcemia
  • Hyperkalemia
  • Hypothermia
  • Pectus excavatum
  • Effects of athletic training

Differential Diagnoses