Brugada Syndrome Questions & Answers

Updated: Apr 03, 2020
  • Author: Jose M Dizon, MD; Chief Editor: Mikhael F El-Chami, MD  more...
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Questions & Answers

Overview

What is Brugada syndrome (BrS)?

What are the signs and symptoms of Brugada syndrome (BrS)?

What is the significance of the lack of prodrome in Brugada syndrome (BrS)?

How is Brugada syndrome (BrS) diagnosed?

Which studies are used to diagnose Brugada syndrome (BrS)?

What is the role of lab testing in the diagnosis of Brugada syndrome (BrS)?

What is the role of echocardiography in the diagnosis of Brugada syndrome (BrS)?

What are the treatment options for Brugada syndrome (BrS)?

What is the role of pharmacologic therapy in the treatment of Brugada syndrome (BrS)?

What is Brugada syndrome (BrS)?

How is the heart affected in Brugada syndrome (BrS)?

What is the role of genetics in the etiology of Brugada syndrome (BrS)?

What are the clinical manifestations of Brugada syndrome (BrS)?

How is ventricular tachycardia managed in Brugada syndrome (BrS)?

What is the pathophysiology of Brugada syndrome (BrS)?

What is the repolarization-defect therapy of the pathogenesis of Brugada syndrome (BrS)?

Which readings on electrocardiogram (ECG) are characteristic of Brugada syndrome (BrS)?

What is depolarization/conduction disorder model of Brugada syndrome (BrS)?

What is the role of ajmaline provocation in the pathogenesis of Brugada syndrome (BrS)?

What is the role of genetics in Brugada syndrome (BrS)?

Which clinical situations may unmask or exacerbate the electrocardiogram (ECG) pattern of Brugada syndrome (BrS)?

What is the prevalence of Brugada syndrome (BrS) in the US?

What is the global prevalence of Brugada syndrome (BrS)?

What are the racial predilections for Brugada syndrome (BrS)?

How does the prevalence of Brugada syndrome (BrS) vary by sex?

How does the prevalence of Brugada syndrome (BrS) vary by age?

What is the prognosis of Brugada syndrome (BrS)?

What are the risk factors for sudden cardiac death in patients with Brugada syndrome (BrS)?

What is the incidence of cardiac death in patients with Brugada syndrome (BrS)?

What is included in the patient education information for Brugada syndrome (BrS)?

Presentation

What are the signs and symptoms of Brugada syndrome (BrS)?

What is a common finding in the history of patients with Brugada syndrome (BrS)?

When do most cardiac events of Brugada syndrome (BrS) occur?

What is the significance of a lack of prodrome in Brugada syndrome (BrS)?

What is the purpose of physical exam in the evaluation of Brugada syndrome (BrS)?

DDX

What is included in the differential diagnoses of cardiac arrest in Brugada syndrome (BrS)?

What is included in differential diagnoses of right precordial ST-segment elevation in Brugada syndrome (BrS)?

What are the differential diagnoses for Brugada Syndrome?

Workup

How should syncope be evaluated in suspected Brugada syndrome (BrS)?

Which lab studies are performed for the diagnosis of Brugada syndrome (BrS)?

What is the role of genetic testing in the diagnosis of Brugada syndrome (BrS)?

What is the role of echocardiography and/or MRI in the diagnosis of Brugada syndrome (BrS)?

Which electrocardiogram (ECG) patterns have been described in Brugada syndrome (BrS)?

What does the QRS duration on the 12-lead electrocardiogram (ECG) suggest in the evaluation of Brugada syndrome (BrS)?

When should an electrophysiologist be consulted in the diagnosis of Brugada syndrome (BrS)?

How are arrhythmogenic right ventricular cardiomyopathy (ARVC) and Brugada syndrome (BrS) differentiated?

What is the role of sodium channel blockers in the workup of Brugada syndrome (BrS)?

What is the purpose of an electrophysiologic study (EPS) in the diagnosis of Brugada syndrome (BrS)?

What is the efficacy of electrophysiologic study (EPS) for the diagnosis of Brugada syndrome (BrS)?

Treatment

What are the treatment options for Brugada syndrome (BrS)?

What are the indications for implantable cardioverter-defibrillator (ICD) implantation in the treatment of Brugada syndrome (BrS)?

What are the treatment options for asymptomatic Brugada syndrome (BrS)?

When is hospitalization indicated for the treatment of Brugada syndrome (BrS)?

What are the activity restrictions for patients with Brugada syndrome (BrS)?

What are the AHA/ACC activity recommendations for patients with Brugada syndrome (BrS)?

Which specialists should be consulted in the diagnosis and management of Brugada syndrome (BrS)?

What is included in the long-term monitoring of patients with Brugada syndrome (BrS)?

Guidelines

What are the HRS/EHRA/ARHRS diagnostic criteria for Brugada syndrome (BrS)?

Which organization released treatment guidelines for ventricular arrhythmias and the prevention of sudden cardiac death (SCD) in patients with Brugada syndrome (BrS)?

What is the ESC diagnostic criteria for Brugada syndrome (BrS)?

What are the HRS/EHRA guidelines for genetic testing in Brugada syndrome (BrS)?

What are the ESC recommendations for lifestyle changes to manage Brugada syndrome (BrS) and prevent sudden cardiac death?

What are the ESC guidelines class IIa level recommendations for the treatment of Brugada syndrome (BrS)?

What are the ESC guidelines class IIb level recommendations for the treatment of Brugada syndrome (BrS)?

What are the AHA/ACC guidelines for athletic competition for patients with Brugada syndrome (BrS)?

Medications

Which medications are used in the treatment of Brugada syndrome (BrS)?

Which medications in the drug class Antiarrhythmic Drugs are used in the treatment of Brugada Syndrome?