Buprenorphine/Naloxone Toxicity Medication

Updated: May 12, 2022
  • Author: Timothy J Wiegand, MD; Chief Editor: Michael A Miller, MD  more...
  • Print

Medication Summary

Some literature reports resistance or difficulty reversing clinical effects of buprenorphine with naloxone. [23] Repeat administration of high doses of naloxone may be needed. If naloxone does not reverse clinical effects, it is imperative that supportive care continues.


Antidote For Narcotic Agonists

Class Summary

This agent is used to reverse the toxic effects of narcotics.

Naloxone (Narcan)

Prevents or reverses opioid effects (hypotension, respiratory depression, sedation), possibly by displacing opiates from their receptors.