Aluminum Toxicity Medication

Updated: Mar 24, 2023
  • Author: Jose F Bernardo, MD, MPH, FASN; Chief Editor: Sage W Wiener, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications. Deferoxamine can be used for chelation therapy.


Metal chelators

Class Summary

These agents bind free metal and do not chelate other trace metals of nutritional importance. Metals are excreted in the urine and bile.

Deferoxamine (Desferal mesylate)

Metal-free ligand of the iron chelate isolated from the bacterium S pilosus. Used for acute and chronic iron toxicity as well as aluminum toxicity and has a high affinity for ferric iron. Does not affect iron in cytochromes or hemoglobin. PO/IM administration not established. Several case reports and cohorts using varying doses indicate effectiveness when administered IV.