Autoimmune Lymphoproliferative Syndrome Questions & Answers

Updated: Jul 29, 2019
  • Author: Akaluck Thatayatikom, MD, RhMSUS; Chief Editor: Harumi Jyonouchi, MD  more...
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Questions & Answers

Overview

What is autoimmune lymphoproliferative syndrome (ALPS)?

What is the pathophysiology of autoimmune lymphoproliferative syndrome (ALPS)?

How is autoimmune lymphoproliferative syndrome (ALPS) classified?

What causes autoimmune lymphoproliferative syndrome (ALPS)?

What are the signs and symptoms of autoimmune lymphoproliferative syndrome (ALPS)?

What is the prognosis of autoimmune lymphoproliferative syndrome (ALPS)?

What is included in patient education about autoimmune lymphoproliferative syndrome (ALPS)?

Presentation

Which clinical history findings are characteristic of autoimmune lymphoproliferative syndrome (ALPS)?

Which physical findings are characteristic of autoimmune lymphoproliferative syndrome (ALPS)?

What are the possible complications of autoimmune lymphoproliferative syndrome (ALPS)?

DDX

How is autoimmune lymphoproliferative syndrome (ALPS) differentiated from more common pediatric rheumatologic or hematologic disorders?

Which conditions are included in the differential diagnoses of autoimmune lymphoproliferative syndrome (ALPS)?

Which specialists should be included on the treatment team for autoimmune lymphoproliferative syndrome (ALPS)?

What are the differential diagnoses for Autoimmune Lymphoproliferative Syndrome?

Workup

How is autoimmune lymphoproliferative syndrome (ALPS) diagnosed?

What is the role of lab tests in the workup of autoimmune lymphoproliferative syndrome (ALPS)?

What is the role of CT and PET scanning in the workup of autoimmune lymphoproliferative syndrome (ALPS)?

What is the role of lymph node biopsy in the workup of autoimmune lymphoproliferative syndrome (ALPS)?

Which histologic findings are characteristic of autoimmune lymphoproliferative syndrome (ALPS)?

How is autoimmune lymphoproliferative syndrome (ALPS) staged?

Treatment

How is autoimmune lymphoproliferative syndrome (ALPS) treated?

How are chronic and refractory autoimmune cytopenia treated in autoimmune lymphoproliferative syndrome (ALPS)?

What is the role of antibiotics in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

What is the role of hematopoietic stem cell transplantation (HSCT) in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

Which specialist consultations are beneficial to patients with autoimmune lymphoproliferative syndrome (ALPS)?

Which dietary modifications are used in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

Which activity modifications are used in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

What is the role of spleen guards in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

How is autoimmune lymphoproliferative syndrome (ALPS) prevented?

Medications

What is the role of medications in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

Which medications in the drug class Immune Globulin are used in the treatment of Autoimmune Lymphoproliferative Syndrome?

Which medications in the drug class Immunosuppressant Agents are used in the treatment of Autoimmune Lymphoproliferative Syndrome?