Systemic Inflammatory Response Syndrome (SIRS) Differential Diagnoses

Updated: May 07, 2018
  • Author: Lewis J Kaplan, MD, FACS, FCCM, FCCP; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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DDx

Diagnostic Considerations

Conditions to consider in the differential diagnosis of systemic inflammatory response syndrome (SIRS) include the following:

  • Abdominal abscess

  • Diverticulitis

  • Electrical injuries

  • Erythema multiforme (Stevens-Johnson syndrome)

  • Gas gangrene

  • Posttransplantation infections

  • Infective endocarditis

  • Influenza

  • Intestinal perforation

  • Meningitis

  • Meningococcemia

  • Multisystem organ failure of sepsis

  • Myocardial Infarction

  • Nosocomial pneumonia

  • Acute pancreatitis [6]

  • Perioperative pulmonary management

  • Community-acquired pneumonia [5]

  • Pseudomembranous colitis

  • Pulmonary embolism

  • Acute pyelonephritis

  • Respiratory failure

  • Bacterial sepsis

  • Septic arthritis

  • Septic shock

  • Toxic epidermal necrolysis

  • Toxic shock syndrome

  • Transfusion reactions

  • Upper gastrointestinal bleeding

  • Female urinary tract infection

  • Male urinary tract infection

  • Autoimmune disorders

  • Chemical aspiration

  • Cutaneous adverse drug reaction

  • Dehydration

  • Medication effects

  • Pulmonary contusions

  • Substance abuse - Stimulants such as cocaine and amphetamines

  • Surgical procedures

  • Viral infections

Differential Diagnoses