Systemic Inflammatory Response Syndrome Differential Diagnoses

Updated: Sep 13, 2017
  • Author: Lewis J Kaplan, MD, FACS, FCCM, FCCP; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM  more...
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DDx

Diagnostic Considerations

Conditions to consider in the differential diagnosis of systemic inflammatory response syndrome (SIRS) include the following:

  • Abdominal abscess
  • Diverticulitis
  • Electrical injuries
  • Erythema multiforme (Stevens-Johnson syndrome)
  • Gas gangrene
  • Posttransplantation infections
  • Infective endocarditis
  • Influenza
  • Intestinal perforation
  • Meningitis
  • Meningococcemia
  • Multisystem organ failure of sepsis
  • Myocardial Infarction
  • Nosocomial pneumonia
  • Acute pancreatitis [6]
  • Perioperative pulmonary management
  • Community-acquired pneumonia [5]
  • Pseudomembranous colitis
  • Pulmonary embolism
  • Acute pyelonephritis
  • Respiratory failure
  • Bacterial sepsis
  • Septic arthritis
  • Septic shock
  • Toxic epidermal necrolysis
  • Toxic shock syndrome
  • Transfusion reactions
  • Upper gastrointestinal bleeding
  • Female urinary tract infection
  • Male urinary tract infection
  • Autoimmune disorders
  • Chemical aspiration
  • Cutaneous adverse drug reaction
  • Dehydration
  • Medication effects
  • Pulmonary contusions
  • Substance abuse - Stimulants such as cocaine and amphetamines
  • Surgical procedures
  • Viral infections

Differential Diagnoses