Systemic Inflammatory Response Syndrome (SIRS) Questions & Answers

Updated: May 07, 2018
  • Author: Lewis J Kaplan, MD, FACS, FCCM, FCCP; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Questions & Answers

Overview

What steps should be taken to prevent complications in systemic inflammatory response syndrome (SIRS)?

How is systemic inflammatory response syndrome (SIRS) defined?

What causes systemic inflammatory response syndrome (SIRS)?

How is infection defined in systemic inflammatory response syndrome (SIRS)?

How is bacteremia defined in systemic inflammatory response syndrome (SIRS)?

How is sepsis-induced hypotension defined in systemic inflammatory response syndrome (SIRS)?

What are serve systemic inflammatory response syndrome (SIRS) and SIRS shock?

What are potential complications in systemic inflammatory response syndrome (SIRS)?

What is the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the pathophysiology of stage I systemic inflammatory response syndrome (SIRS)?

What is the pathophysiology of stage II systemic inflammatory response syndrome (SIRS)?

What is the pathophysiology of stage III systemic inflammatory response syndrome (SIRS)?

What is the multi-hit theory in the progression of systemic inflammatory response syndrome (SIRS)?

What is the pathophysiology of the inflammatory cascade in systemic inflammatory response syndrome (SIRS)?

What is the role of proinflammatory mediators in the pathophysiology of systemic inflammatory response syndrome (SIRS)?

What is the role of high mobility group box 1 (HMGB1) in the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the role of proinflammatory polypeptides in the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the role of polymorphonuclear cells (PMNs) in the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the role of coagulation in the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the role of counter-inflammatory response syndrome (CARS) in the pathogenesis of systemic inflammatory response syndrome (SIRS)?

What is the etiology of systemic inflammatory response syndrome (SIRS)?

What are the infectious causes of systemic inflammatory response syndrome (SIRS)?

What are the noninfectious causes of systemic inflammatory response syndrome (SIRS)?

What is the incidence of systemic inflammatory response syndrome (SIRS) in the US?

What is the global incidence of systemic inflammatory response syndrome (SIRS)?

How does the mortality rate of systemic inflammatory response syndrome (SIRS) vary between men and women?

How does age affect the prognosis of systemic inflammatory response syndrome (SIRS)?

What is the mortality rate associated with systemic inflammatory response syndrome (SIRS)?

What factors affect the prognosis of systemic inflammatory response syndrome (SIRS)?

What are the in-hospital mortality rates for systemic inflammatory response syndrome (SIRS)?

Which systemic inflammatory response syndrome (SIRS) etiology increases the mortality risk?

What should patient education for patients with systemic inflammatory response syndrome (SIRS) target?

Presentation

How does medication history affect the diagnosis of systemic inflammatory response syndrome (SIRS)?

What should be the focus of clinical history when systemic inflammatory response syndrome (SIRS) is suspected?

How can pain help guide a physician in the differential diagnosis of systemic inflammatory response syndrome (SIRS)?

When is a complete physical exam indicated in the evaluation of systemic inflammatory response syndrome (SIRS)?

What are the diagnostic criteria for systemic inflammatory response syndrome (SIRS)?

What should be considered during the physical exam of systemic inflammatory response syndrome (SIRS)?

DDX

What conditions should be considered in the differential diagnosis of systemic inflammatory response syndrome (SIRS)?

What are the differential diagnoses for Systemic Inflammatory Response Syndrome (SIRS)?

Workup

What is the role of lab testing in the evaluation for systemic inflammatory response syndrome (SIRS)?

What testing should be included in routine screenings for systemic inflammatory response syndrome (SIRS)?

What is the significance of increased interleukin 6 (IL-6) levels in systemic inflammatory response syndrome (SIRS)?

What is the significance of elevated blood lactate levels in systemic inflammatory response syndrome (SIRS)?

What is the role of imaging studies in the diagnosis of systemic inflammatory response syndrome (SIRS)?

Which patient groups require more intensive evaluation for systemic inflammatory response syndrome (SIRS)?

How are infectious causes of systemic inflammatory response syndrome (SIRS) differentiated from noninfectious causes?

What is the role of leptin measurement in the evaluation of systemic inflammatory response syndrome (SIRS)?

Treatment

What is the role of antibiotic therapy for systemic inflammatory response syndrome (SIRS)?

When are broad-spectrum antibiotics indicated in the treatment of systemic inflammatory response syndrome (SIRS)?

What are the treatment options for dermatologic infections of systemic inflammatory response syndrome (SIRS)?

Is antiviral therapy used in the treatment of systemic inflammatory response syndrome (SIRS)?

When is antifungal therapy indicated in the treatment of systemic inflammatory response syndrome (SIRS)?

How does the inflammatory mediators and receptors differ in infectious and noninfectious systemic inflammatory response syndrome (SIRS)?

What is the indication for steroid therapy for systemic inflammatory response syndrome (SIRS)?

What is the role of vasopressin for the treatment of systemic inflammatory response syndrome (SIRS)?

What is the role of adrenocorticotropic hormone (ACTH) stimulation testing in the management of systemic inflammatory response syndrome (SIRS)?

How frequently is hyperglycemia present in systemic inflammatory response syndrome (SIRS)?

What is the pathogenesis of hyperglycemia in systemic inflammatory response syndrome (SIRS) and what are its effects?

What are the benefits of intensive glycemic control in patients with systemic inflammatory response syndrome (SIRS)?

What is the role of supplemental oxygen in the treatment of systemic inflammatory response syndrome (SIRS)?

Which specialist consultations are needed for the treatment of systemic inflammatory response syndrome (SIRS)?

What is the focus of treatment for systemic inflammatory response syndrome (SIRS)?

How is hypotension in systemic inflammatory response syndrome (SIRS) treated?

When is surgery indicated in the treatment of systemic inflammatory response syndrome (SIRS)?

What is the role of nutrition in the treatment of systemic inflammatory response syndrome (SIRS)?

Which complications of systemic inflammatory response syndrome (SIRS) require prophylactic management?

What are the requirements for transfer in patients with systemic inflammatory response syndrome (SIRS)?

Medications

What is the drug of choice for systemic inflammatory response syndrome (SIRS)?

What is the indication for broad-spectrum antibiotics in the treatment of systemic inflammatory response syndrome (SIRS)?

Which medications are used to treat systemic inflammatory response syndrome (SIRS)?

Which medications in the drug class Antifungals, Systemic are used in the treatment of Systemic Inflammatory Response Syndrome (SIRS)?

Which medications in the drug class Antidiabetic Agents are used in the treatment of Systemic Inflammatory Response Syndrome (SIRS)?

Which medications in the drug class Corticosteroids are used in the treatment of Systemic Inflammatory Response Syndrome (SIRS)?

Which medications in the drug class Antibiotics, Other are used in the treatment of Systemic Inflammatory Response Syndrome (SIRS)?