Multiple Organ Dysfunction Syndrome in Sepsis Questions & Answers

Updated: Jan 27, 2020
  • Author: Ali H Al-Khafaji, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Questions & Answers

Overview

What is multiple organ dysfunction syndrome (MODS)?

What is sepsis and what is its clinical progression?

What is systemic inflammatory response syndrome (SIRS)?

How are sepsis and systemic inflammatory response syndrome (SIRS) differentiated?

What is the Sequential [sepsis-related] Organ Failure Assessment (SOFA) score and how is it used in the diagnosis of multiple organ dysfunction syndrome in sepsis?

What is the pathophysiology of sepsis?

What is the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of circulatory derangement in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of microcirculatory dysfunction and mitochondrial depression in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of pulmonary dysfunction in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of GI dysfunction in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of liver dysfunction in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of renal dysfunction in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of the CNS in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of coagulopathy in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What are the mechanisms of cell injury, in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of hypoxic hypoxia in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of direct cytotoxicity in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of apoptosis in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of immunosuppression in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of host response to infection in the pathophysiology of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the incidence of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the prognosis of multiple organ dysfunction syndrome (MODS) in sepsis?

Presentation

What are the signs and symptoms of multiple organ dysfunction syndrome (MODS) in sepsis?

What are localizing symptoms of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the focus of the physical exam for multiple organ dysfunction syndrome (MODS) in sepsis?

Which physical signs suggest focal and bacterial infection in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

DDX

What are the differential diagnoses for Multiple Organ Dysfunction Syndrome in Sepsis?

Workup

Which studies are performed in the workup of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of imaging studies in the evaluation of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of blood tests in the diagnosis of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of metabolic assessment in the diagnosis of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of coagulation tests and blood cultures in the diagnosis of multiple organ dysfunction syndrome (MODS) in sepsis?

Which lab findings suggest bacteremia in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of urine studies in the diagnosis of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of lumbar puncture (LP) in the diagnosis of multiple organ dysfunction syndrome (MODS) in sepsis?

Which procedures are performed for monitoring of suspected multiple organ dysfunction syndrome (MODS) in sepsis?

How is respiratory distress managed in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of pulmonary dysfunction in the staging of multiple organ dysfunction syndrome (MODS) in sepsis?

What criteria are used to stage multiple organ dysfunction syndrome (MODS) in sepsis?

What are the presentations of the non-pulmonary form of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of surgical drainage and debridement in the evaluation of multiple organ dysfunction syndrome (MODS) in sepsis?

Treatment

What are the treatment goals for septic shock and how are they accomplished?

How is septic shock identified in patients with multiple organ dysfunction syndrome (MODS)?

What is included in the initial treatment of septic shock in patients with multiple organ dysfunction syndrome (MODS)?

What is the role of drotrecogin alfa (activated protein C) in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

How is lactic acidosis managed in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of immunosuppression in the treatment multiple organ dysfunction syndrome (MODS) in sepsis?

What is included in the general management for multiple organ dysfunction syndrome (MODS) in sepsis?

How is multiple organ dysfunction syndrome (MODS) in sepsis diagnosed?

What is the role of antimicrobial therapy in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

What are the procedures for source control in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

How are infections prevented in patients with multiple organ dysfunction syndrome (MODS) in sepsis?

What is the preferred resuscitation fluid for the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

How are empiric antimicrobial therapies selected for the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of vasopressor therapy in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of norepinephrine in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of epinephrine in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of dopamine in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What are the roles of phenylephrine and angiotensin II in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of inotropic therapy in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of activated protein C therapy in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the efficacy of corticosteroid therapy in the management of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of corticosteroids in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

What is the role of tight blood glucose management in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

Which medical personnel provide consultation to patients with multiple organ dysfunction syndrome (MODS) in sepsis?

What should be included in long-term monitoring of patients with multiple organ dysfunction syndrome (MODS) in sepsis?

How is multiple organ dysfunction syndrome (MODS) in sepsis prevented?

Medications

Which medical treatments are used in the treatment of multiple organ dysfunction syndrome (MODS) in sepsis?

Which medications in the drug class Cardiovascular, Other are used in the treatment of Multiple Organ Dysfunction Syndrome in Sepsis?

Which medications in the drug class Antibiotics, Other are used in the treatment of Multiple Organ Dysfunction Syndrome in Sepsis?

Which medications in the drug class Blood Components are used in the treatment of Multiple Organ Dysfunction Syndrome in Sepsis?

Which medications in the drug class Electrolytes are used in the treatment of Multiple Organ Dysfunction Syndrome in Sepsis?