Celiac Disease (Sprue) Questions & Answers

Updated: Oct 10, 2018
  • Author: Stephan U Goebel, MD; Chief Editor: BS Anand, MD  more...
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Questions & Answers

Overview

What is celiac disease?

What happens when patients with celiac disease ingest gliadin?

What are the GI symptoms of celiac disease?

What are the extraintestinal symptoms of celiac disease?

What causes a bleeding diathesis in celiac disease?

Which physical findings suggest celiac disease?

What are the American College of Gastroenterology (ACG) recommendations for the diagnosis of celiac disease?

Which lab tests may be performed in the diagnosis of celiac disease?

Which conditions should screened in patients with confirmed celiac disease?

What is the role of imaging studies in the diagnosis of celiac disease?

How is celiac disease histologically graded?

What is the primary treatment for celiac disease?

What is celiac disease?

What is the pathophysiology of celiac disease?

What are the causes of celiac disease?

What is crucial for the pathogenesis of celiac disease?

What is the role of gliadin in the etiology of celiac disease?

What is the role of immunoglobulin A (IgA) antibodies in the etiology of celiac disease?

What is the role of cell-mediated immune responses in the pathogenesis of celiac disease?

What is the role or genetics in the etiology of celiac disease?

How does the prevalence of celiac disease vary by race and sex?

What is the prevalence of celiac disease in the US?

What is the incidence of undiagnosed celiac disease in the US?

What is the global prevalence of celiac disease?

How does the prevalence of celiac disease vary by age?

What is the prognosis of celiac disease?

What are the morbidities of celiac disease?

What are possible complications of celiac disease?

What are the risks of untreated celiac disease during pregnancy?

What causes short stature in patients with celiac disease?

What are symptoms of celiac disease malabsorption?

Which malignant diseases are associated with celiac disease?

What are the symptoms of refractory celiac disease?

What are the types of refractory celiac disease?

Presentation

What are the manifestations of untreated celiac disease?

What is the most common symptom in untreated celiac disease?

What is the pathophysiology of ingested fat malabsorption in celiac disease?

What causes flatulence and borborygmus in celiac disease?

Why is weight loss variable in celiac disease?

What causes weakness and fatigue in celiac disease?

How is abdominal pain characterized in celiac disease?

What causes anemia in celiac disease?

What causes a bleeding in celiac disease?

What causes osteopenia and osteoporosis in celiac disease?

What are the neurologic symptoms of celiac disease?

What are the dermatologic symptoms of celiac disease?

Which hormonal disorders are associated with celiac disease?

What are the physical findings characteristic of celiac disease?

DDX

What are the differential diagnoses for Celiac Disease (Sprue)?

Workup

How is the diagnosis of celiac disease confirmed?

What are the 2013 American College of Gastroenterology (ACG) guidelines for the diagnosis and treatment of celiac disease?

What are the College of Family Physicians of Canada recommendations for managing bone health in adult and pediatric patients with celiac disease?

What is the efficacy of screening strategies for undiagnosed celiac disease?

What is the role of small-bowel biopsy in the diagnosis of celiac disease?

Which conditions increase the risk for celiac disease?

Which lab findings suggest celiac disease?

What is the role of hematologic tests in the diagnosis of celiac disease?

What is the role of stool exam in the diagnosis of celiac disease?

What is the role of oral tolerance tests in the diagnosis of celiac disease?

Which antibody tests are used to confirm the diagnosis of celiac disease?

What is the role of antigliadin and immunoglobulin A (IgA) antibody testing in the diagnosis of celiac disease?

What is the prevalence of seronegative celiac disease?

What is the role of genetic testing in the diagnosis of celiac disease?

What is the purpose of diagnostic algorithms for celiac disease?

What is the role of radiography in the diagnosis of celiac disease?

What is the role of upper endoscopy in the diagnosis of celiac disease?

Which histologic findings are characteristic of celiac disease?

What are the histologic stages of celiac disease?

Treatment

What is the primary treatment for celiac disease?

Which food labeling definitions are important in the management of celiac disease?

When are oats reintroduced into the diet in patients with celiac disease?

How does the timing of gluten introduction affect the risk of developing celiac disease?

What is the role of corticosteroids in the treatment of celiac disease?

Which specialist consultations are helpful for patients with celiac disease?

Medications

What are the goals of drug treatment for celiac disease?

Which medications in the drug class Corticosteroids are used in the treatment of Celiac Disease (Sprue)?