Colonic Polyps Questions & Answers

1. PDQ Screening and Prevention Editorial Board. Colorectal cancer screening (PDQ®): health professional version. February 28, 2020. National Cancer Institute. Available at https://www.cancer.gov/types/colorectal/hp/colorectal-screening-pdq. Accessed: March 6, 2020.

2. Nishihara R, Wu K, Lochhead P, et al. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med. 2013 Sep 19. 369(12):1095-105. [QxMD MEDLINE Link]. [Full Text].

3. Benard F, Barkun AN, Martel M, von Renteln D. Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations. World J Gastroenterol. 2018 Jan 7. 24(1):124-38. [QxMD MEDLINE Link]. [Full Text].

4. WebMD. Pill camera to check colon approved by FDA. Feb 5, 2014. Available at https://www.webmd.com/colorectal-cancer/news/20140204/pill-camera-colon. Accessed: Feb 11, 2014.

5. Pasha SF. Applications of colon capsule endoscopy. Curr Gastroenterol Rep. 2018 Apr 12. 20(5):22. [QxMD MEDLINE Link].

6. Kiesslich R, Goetz M, Lammersdorf K, et al. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology. 2007 Mar. 132(3):874-82. [QxMD MEDLINE Link].

7. Spring KJ, Zhao ZZ, Karamatic R, et al. High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology. 2006 Nov. 131(5):1400-7. [QxMD MEDLINE Link].

8. [Guideline] Rex DK, Boland CR, Dominitz JA, et al. Colorectal cancer screening: recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 Jul. 153(1):307-23. [QxMD MEDLINE Link]. [Full Text].

9. [Guideline] Rex DK, Johnson DA, Anderson JC, et al, for the American College of Gastroenterology. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009 Mar. 104(3):739-50. [QxMD MEDLINE Link]. [Full Text].

10. Ferlitsch M, Reinhart K, Pramhas S, et al. Sex-specific prevalence of adenomas, advanced adenomas, and colorectal cancer in individuals undergoing screening colonoscopy. JAMA. 2011 Sep 28. 306(12):1352-8. [QxMD MEDLINE Link].

11. Stryker SJ, Wolff BG, Culp CE, et al. Natural history of untreated colonic polyps. Gastroenterology. 1987 Nov. 93(5):1009-13. [QxMD MEDLINE Link].

12. Calderwood AH, Lasser KE, Roy HK. Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer. World J Gastrointest Oncol. 2016 Dec 15. 8(12):826-34. [QxMD MEDLINE Link].

13. Powell SM. Direct analysis for familial adenomatous polyposis mutations. Mol Biotechnol. 2002 Feb. 20(2):197-207. [QxMD MEDLINE Link].

14. Dabbous HK, Mohamed YAE, El-Folly RF, El-Talkawy MD, Seddik HE, Johar D, et al. Evaluation of fecal M2PK as a diagnostic marker in colorectal cancer. J Gastrointest Cancer. 2019 Sep. 50(3):442-450. [QxMD MEDLINE Link].

15. Kim DH, Pickhardt PJ, Taylor AJ, et al. CT colonography versus colonoscopy for the detection of advanced neoplasia. N Engl J Med. 2007 Oct 4. 357(14):1403-12. [QxMD MEDLINE Link].

16. Benson M, Dureja P, Gopal D, Reichelderfer M, Pfau PR. A comparison of optical colonoscopy and CT colonography screening strategies in the detection and recovery of subcentimeter adenomas. Am J Gastroenterol. 2010 Dec. 105(12):2578-85. [QxMD MEDLINE Link].

17. Shah JP, Hynan LS, Rockey DC. Management of small polyps detected by screening CT colonography: patient and physician preferences. Am J Med. 2009 Jul. 122(7):687.e1-9. [QxMD MEDLINE Link].

18. Liedenbaum MH, van Rijn AF, de Vries AH, et al. Using CT colonography as a triage technique after a positive faecal occult blood test in colorectal cancer screening. Gut. 2009 Sep. 58(9):1242-9. [QxMD MEDLINE Link]. [Full Text].

19. Hagel AF, Gabele E, Raithel M, et al. Colon capsule endoscopy: Detection of colonic polyps compared with conventional colonoscopy and visualization of extracolonic pathologies. Can J Gastroenterol Hepatol. 2014 Feb. 28(2):77-82. [QxMD MEDLINE Link].

20. Parker CE, Spada C, McAlindon M, Davison C, Panter S. Capsule endoscopy--not just for the small bowel: a review. Expert Rev Gastroenterol Hepatol. 2015 Jan. 9(1):79-89. [QxMD MEDLINE Link].

21. Mitchell RA, Zhang C, Galorport C, Walker B, Telford J, Enns R. Characteristics of patients with colonic polyps requiring segmental resection. Can J Gastroenterol Hepatol. 2018 Feb 11. 2018:7046385. [QxMD MEDLINE Link]. [Full Text].

22. Van Gossum A, Munoz-Navas M, Fernandez-Urien I, et al. Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. N Engl J Med. 2009 Jul 16. 361(3):264-70. [QxMD MEDLINE Link].

23. Itzkowitz SH, Jandorf L, Brand R, et al. Improved fecal DNA test for colorectal cancer screening. Clin Gastroenterol Hepatol. 2007 Jan. 5(1):111-7. [QxMD MEDLINE Link].

24. Heresbach D, Chauvin P, Hess-Migliorretti A, Riou F, Grolier J, Josselin JM. Cost-effectiveness of colorectal cancer screening with computed tomography colonography according to a polyp size threshold for polypectomy. Eur J Gastroenterol Hepatol. 2010 Jun. 22(6):716-23. [QxMD MEDLINE Link].

25. Shinozaki S, Kobayashi Y, Hayashi Y, Sakamoto H, Lefor AK, Yamamoto H. Efficacy and safety of cold versus hot snare polypectomy for resecting small colorectal polyps: Systematic review and meta-analysis. Dig Endosc. 2018 Sep. 30(5):592-9. [QxMD MEDLINE Link].

26. Goh C, Burke JP, McNamara DA, Cahill RA, Deasy J. Endolaparoscopic removal of colonic polyps. Colorectal Dis. 2014 Apr. 16(4):271-5. [QxMD MEDLINE Link].

27. Zafar A, Mustafa M, Chapman M. Colorectal polyps: when should we tattoo?. Surg Endosc. 2012 Nov. 26(11):3264-6. [QxMD MEDLINE Link].

28. Jover R, Dekker E. Surveillance after colorectal polyp removal. Best Pract Res Clin Gastroenterol. 2016 Dec. 30(6):937-48. [QxMD MEDLINE Link].

29. [Guideline] Giardiello FM, Allen JI, Axilbund JE, et al, for the American Society for Gastrointestinal Endoscopy. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2014 Aug. 80(2):197-220. [QxMD MEDLINE Link]. [Full Text].

30. [Guideline] Kahi CJ, Boland CR, Dominitz JA, et al, for the United States Multi-Society Task Force on Colorectal Cancer. Colonoscopy surveillance after colorectal cancer resection: recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2016 Mar. 150(3):758-768.e11. [QxMD MEDLINE Link].

31. [Guideline] Lieberman DA, Rex DK, Winawer SJ, Giardiello FM, Johnson DA, Levin TR. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2012 Sep. 143(3):844-57. [QxMD MEDLINE Link].

32. Beach R, Chan AO, Wu TT, et al. BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol. 2005 Apr. 166(4):1069-75. [QxMD MEDLINE Link].

33. Burke CA, Choure AG, Sanaka MR, Lopez R. A comparison of high-definition versus conventional colonoscopes for polyp detection. Dig Dis Sci. 2010 Jun. 55(6):1716-20. [QxMD MEDLINE Link].

34. Bussey HJ, DeCosse JJ, Deschner EE, et al. A randomized trial of ascorbic acid in polyposis coli. Cancer. 1982 Oct 1. 50(7):1434-9. [QxMD MEDLINE Link].

35. Cohen LB. A color atlas of colorectal lesions. In: Pazdur R, Hoskins WJ, Wagman L, Coia LR, eds. Cancer Management: A Multidisciplinary Approach. Huntington, NY: Publisher Research & Representation, Inc; 2000. 301-5.

36. Coia LR, Ellenhorn JDI, Ayoub JP. Colorectal and anal cancers. In: Pazdur R, Hoskins WJ, Wagman L, Coia LR, eds. Cancer Management: A Multidisciplinary Approach. Huntington, NY: Publisher Research & Representation, Inc; 2000. 273-99.

37. Cotran RS, Kumar V, Robbins SL. Tumors of the small and large intestines. In: Cotran R, Kumar V, Robbins S, eds. Pathologic Basis of Disease. 5th ed. Huntington, NY: WB Saunders Company; 1994. 809-22.

38. Giardiello FM, Offerhaus GJ, DuBois RN. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Eur J Cancer. 1995 Jul-Aug. 31A(7-8):1071-6. [QxMD MEDLINE Link].

39. Itzkowitz SH, Kim YS. Colonic polyps and polyposis syndromes. In: Feldman M, Sleisenger MH, Scharschmidt BF, eds. Sleisinger & Fordtran's Gastrointestinal and Liver Disease; Pathophysiology, Diagnosis, Management. 6th ed. Philadelphia, Pa: WB Saunders Company; 1998. Vol 2: 1865-1905.

40. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996 Oct 18. 87(2):159-70. [QxMD MEDLINE Link].

41. Ladabaum U, Song K. Projected national impact of colorectal cancer screening on clinical and economic outcomes and health services demand. Gastroenterology. 2005 Oct. 129(4):1151-62. [QxMD MEDLINE Link].

42. Logan RF, Grainge MJ, Shepherd VC, et al. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology. 2008 Jan. 134(1):29-38. [QxMD MEDLINE Link].

43. Powell SM, Petersen GM, Krush AJ, et al. Molecular diagnosis of familial adenomatous polyposis. N Engl J Med. 1993 Dec 30. 329(27):1982-7. [QxMD MEDLINE Link].

44. Regueiro CR. AGA future trends committee report. Colorectal cancer: a qualitative review of emerging screening and diagnostic technologies. Gastroenterology. 2005 Sep. 129(3):1083-103. [QxMD MEDLINE Link].

45. Swan MP, Bourke MJ, Alexander S, Moss A, Williams SJ. Large refractory colonic polyps: is it time to change our practice? A prospective study of the clinical and economic impact of a tertiary referral colonic mucosal resection and polypectomy service (with videos). Gastrointest Endosc. 2009 Dec. 70(6):1128-36. [QxMD MEDLINE Link].

46. Qureshi A, Al Shihi S, Ali Z, Shalaby A. A retrospective study of clinico-pathological characteristics of colonic polyps in adults seen at a tertiary care centre. J Pak Med Assoc. 2017 Jan. 67(1):12-4. [QxMD MEDLINE Link].

47. Wada Y, Fukuda M, Ohtsuka K, et al. Efficacy of Endocuff-assisted colonoscopy in the detection of colorectal polyps. Endosc Int Open. 2018 Apr. 6(4):E425-E431. [QxMD MEDLINE Link]. [Full Text].

48. [Guideline] Messersmith WA. NCCN guidelines updates: management of metastatic colorectal cancer. J Natl Compr Canc Netw. 2019 May 1. 17(5.5):599-601. [QxMD MEDLINE Link]. [Full Text].

49. [Guideline] Vogl TJ, Pereira PL, Helmberger T, et al. Updated S3 guidelines - diagnosis and treatment of colorectal carcinoma: relevance for radiological diagnosis and intervention. Rofo. 2019 Apr. 191 (4):298-310. [QxMD MEDLINE Link]. [Full Text].

50. [Guideline] East JE, Atkin WS, Bateman AC, et al. British Society of Gastroenterology position statement on serrated polyps in the colon and rectum. Gut. 2017 Jul. 66(7):1181-96. [QxMD MEDLINE Link]. [Full Text].

51. [Guideline] Herzig D, Hardiman K, Weiser M, et al. The American Society of Colon and Rectal Surgeons Clinical practice guidelines for the management of inherited polyposis syndromes. Dis Colon Rectum. 2017 Sep. 60(9):881-94. [QxMD MEDLINE Link]. [Full Text].

Gregory H Enders, MD, PhD Gastroenterologist, Moses Taylor Hospital, Regional Hospital of Scranton, and Physicians Health Alliance

Gregory H Enders, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Gastroenterological Association

Disclosure: Nothing to disclose.

Wafik S El-Deiry, MD, PhD Rose Dunlap Professor of Medicine, Chief, Division of Hematology and Oncology, Penn State Hershey Medical Center

Wafik S El-Deiry, MD, PhD is a member of the following medical societies: American Association for Cancer Research, American Society for Clinical Investigation, American Society of Gene and Cell Therapy

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Manoop S Bhutani, MD Professor, Co-Director, Center for Endoscopic Research, Training and Innovation (CERTAIN), Director, Center for Endoscopic Ultrasound, Department of Medicine, Division of Gastroenterology, University of Texas Medical Branch; Director, Endoscopic Research and Development, The University of Texas MD Anderson Cancer Center

Manoop S Bhutani, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Institute of Ultrasound in Medicine, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Research on colon neoplasia in the author's laboratory has been supported by NIH grant #R01DK64758.

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