Cytomegalovirus Colitis Differential Diagnoses

Updated: May 17, 2021
  • Author: Douglas M Heuman, MD, FACP, FACG, AGAF; Chief Editor: BS Anand, MD  more...
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Diagnostic Considerations

Special concerns

In high-risk patients, only use cytomegalovirus (CMV)-seronegative blood. CMV vaccines are under development.

When matching organs, only use organs from seronegative donors.

Prophylactic colon screening has not been beneficial.

Other problems to be considered

Other conditions to consider in patients with suspected CMV colitis include the following:

  • Entamoeba histolytica infection

  • Clostridium difficile infection (CDI): In rare cases, CMV colitis may coexist with CDI in immunocompetent patients; affected patients may present with abdominal pain and watery or bloody diarrhea and experience disease that is refractory to standard therapies for CDI. [10] Real-time polymerase chain reaction (RT-PCR) findings from blood/stool samples to identify CMV infection may be useful in this type of clinical setting.

Differential Diagnoses