Dubin-Johnson Syndrome Differential Diagnoses

Updated: Jun 24, 2015
  • Author: Simon S Rabinowitz, MD, PhD, FAAP; Chief Editor: BS Anand, MD  more...
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Diagnostic Considerations

Initially, patients with jaundice must be determined to have directly reacting hyperbilirubinemia, other causes of which, aside from Dubin-Johnson syndrome, include the following:

  • Rotor syndrome: This condition, especially with normal liver transaminase levels and normal family history, may be the cause of the jaundice
  • Obstructive cholestasis with stones in the cystic duct: These can demonstrate hepatic uptake but delayed or no visualization of the gallbladder on nuclear medicine studies

Virtually all hepatic diseases that cause directly reacting hyperbilirubinemia, including the following, are accompanied by elevated transaminase levels as well:

  • Viral hepatitis
  • Autoimmune hepatitis
  • Alcoholism and other hepatotoxic exposure
  • Sepsis
  • Hepatic storage diseases
  • Infiltrative diseases such as hepatoblastoma
  • Hepatocellular carcinoma
  • Metastatic liver disease