Esophageal Diverticula Medication

Updated: Jun 18, 2014
  • Author: Jack Bragg, DO; Chief Editor: Julian Katz, MD  more...
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Medication

Medication Summary

Botulinum toxin has been used successfully as an alternative to surgical myotomy or pneumatic dilation for the treatment of achalasia.

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Neuromuscular blocker agents

Class Summary

May relax smooth muscle.

OnabotulinumtoxinA (BOTOX®)

Botulinum toxin type A is produced by Clostridium botulinum and is responsible for botulism in humans. Botulinum toxin type A produces denervation of affected muscle tissue by irreversibly binding to presynaptic nerve endings and inhibiting the release of acetylcholine.

When endoscopically injected into the lower esophageal sphincter (LES), interference with cholinergic transmission of the myenteric plexus leads to smooth muscle relaxation with a subsequent fall of the LES resting pressure. This drug has been used in other fields of medicine to treat spastic torticollis and blepharospasm.

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