Esophageal Lymphoma Differential Diagnoses

Updated: Sep 03, 2019
  • Author: Victor Velocci, MD; Chief Editor: BS Anand, MD  more...
  • Print

Diagnostic Considerations

In patients with HIV or AIDS, consider an underlying esophageal lymphoma in a clinical presentation consistent with infectious esophagitis that is not responsive to adequate therapy. This is especially true when esophageal ulcerations are present.

Superinfection with Candida albicans is common and may lead to repeated treatment with antifungal medications rather than the pursuit of alternative diagnoses for a nonhealing esophageal ulcer.

Conditions to be considered in the differential diagnosis of esophageal lymphoma include the following:

  • Cytomegalovirus esophagitis

  • Esophageal candidiasis

  • Esophageal leiomyosarcoma

  • Herpes simplex esophagitis

  • Idiopathic esophageal ulceration