Familial Adenomatous Polyposis Medication

Updated: Oct 10, 2016
  • Author: Mohammad Wehbi, MD; Chief Editor: BS Anand, MD  more...
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Medication

Medication Summary

The goal of pharmacotherapy is to reduce morbidity and to prevent complications.

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Nonsteroidal anti-inflammatory drugs

Class Summary

These agents are used to reduce the number and the size of adenomatous polyps that remain in the rectum or ileal pouch after colectomy in patients with FAP. Celecoxib is not widely used because of the association between COX-2 inhibitors (celecoxib is a member of this drug family) and coronary artery disease.

Sulindac (Clinoril)

Sulfoxide is a nonsteroidal anti-inflammatory agent that is metabolized to the anti-inflammatory sulfide metabolite and a sulfone metabolite. Sulfide metabolite is now known to have apoptotic activity on colonic epithelial cells and is presumed to be responsible for the regression of adenomatous polyps.

Celecoxib (Celebrex)

Primarily inhibits COX-2. COX-2 is considered an inducible isoenzyme, induced during pain and inflammatory stimuli. COX-2 is overexpressed in colonic adenomas, which may contribute to adenoma growth, and inhibition of COX-2 may be the mechanism for polyp regression.

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