Atrophic Gastritis Differential Diagnoses

Updated: Dec 20, 2018
  • Author: Nafea Zayouna, MD; Chief Editor: BS Anand, MD  more...
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DDx

Diagnostic Considerations

Chronic atrophic gastritis with intestinal metaplasia is recognized to be a precancerous lesion that can evolve toward low- and high-grade intraepithelial lesions and gastric cancer, particularly those involving H pylori infection. [1] Clinicians must identify patients at risk of developing gastric carcinoma to increase clinical surveillance, early recognition, and prompt treatment. At present, the Operative Link on Gastritis Assessment (OLGA) staging system appears to be the most reliable and powerful system for identifying these high-risk patients. [1]

Autoimmune atrophic gastritis has been associated with thyroid diseases, type 1 diabetes mellitus, Addison disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions (eg, erosive oral lichen planus). [2] Thus, in the setting of any autoimmune condition and increased autoimmune disease clustering, clinicians should rule out concomitant autoimmune conditions. [2]

Differential Diagnoses