Gastroesophageal Reflux Disease Questions & Answers

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23. El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol. 2005 Jun. 100(6):1243-50. [QxMD MEDLINE Link].

24. Tutuian R,. Adverse effects of drugs on the esophagus. Best Pract Res Clin Gastroenterol. 2010 Apr. 24(2):91-7. [QxMD MEDLINE Link].

25. Galmiche JP, Hatlebakk J, Attwood S, et al. Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial. JAMA. 2011 May 18. 305(19):1969-77. [QxMD MEDLINE Link].

26. Bhatia J, Parish A. GERD or not GERD: the fussy infant. J Perinatol. 2009 May. 29 suppl 2:S7-11. [QxMD MEDLINE Link].

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28. Ponce J, Garrigues V, Agreus L, et al. Structured management strategy based on the Gastro-oesophageal Reflux Disease (GERD) Questionnaire (GerdQ) vs. usual primary care for GERD: pooled analysis of five cluster-randomised European studies. Int J Clin Pract. 2012 Sep. 66(9):897-905. [QxMD MEDLINE Link].

29. Woodcock J. Statement alerting patients and health care professionals of NDMA found in samples of ranitidine [news release]. September 13, 2019. US Food and Drug Administration. Available at https://www.fda.gov/news-events/press-announcements/statement-alerting-patients-and-health-care-professionals-ndma-found-samples-ranitidine. 2019 Jun; Accessed: October 15, 2020.

30. US Food and Drug Administration. FDA requests removal of all ranitidine products (Zantac) from the market [news release]. April 1, 2020. Available at https://www.fda.gov/news-events/press-announcements/fda-requests-removal-all-ranitidine-products-zantac-market. Accessed: October 15, 2020.

31. Yang YX, Lewis JD, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006 Dec 27. 296(24):2947-53. [QxMD MEDLINE Link]. [Full Text].

32. Kellerman R, Kintanar T. Gastroesophageal reflux disease. Prim Care. 2017 Dec. 44(4):561-73. [QxMD MEDLINE Link].

33. US Food and Drug Administration Press Announcements. FDA approves first generic versions of Aciphex delayed-release tablets to treat GERD. US Food and Drug Administration. Available at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm374329.htm. Accessed: November 12, 2013.

34. Agency for Healthcare Research and Quality. Comparative effectiveness of management strategies for gastroesophageal reflux disease - executive summary. AHRQ pub. no. 06-EHC003-1. December 2005. Available at http://effectivehealthcare.ahrq.gov/healthInfo.cfm?infotype=rr&ProcessID=1&DocID=42. Accessed: September 27, 2010.

35. Rassameehiran S, Klomjit S, Hosiriluck N, Nugent K. Meta-analysis of the effect of proton pump inhibitors on obstructive sleep apnea symptoms and indices in patients with gastroesophageal reflux disease. Proc (Bayl Univ Med Cent). 2016 Jan. 29(1):3-6. [QxMD MEDLINE Link].

36. Phathom Pharmaceuticals. Phathom Pharmaceuticals announces FDA approval of VOQUEZNA (vonoprazan) tablets for the treatment of erosive GERD and relief of heartburn associated with erosive GERD in adults [news release]. Available at https://investors.phathompharma.com/news-releases/news-release-details/phathom-pharmaceuticals-announces-fda-approval-voqueznar. November 1, 2023; Accessed: November 9, 2023.

37. Phathom Pharmaceuticals announces positive topline results from PHALCON-EE pivotal phase 3 erosive esophagitis trial. Phathom Pharmaceuticals. Available at https://investors.phathompharma.com/news-releases/news-release-details/phathom-pharmaceuticals-announces-positive-topline-results-0. October 18, 2021; Accessed: November 9, 2023.

38. Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, et al. Vonoprazan versus lansoprazole for healing and maintenance of healing of erosive esophagitis: a randomized trial. Gastroenterology. 2023 Jan. 164 (1):61-71. [QxMD MEDLINE Link]. [Full Text].

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42. Nissen R, Rossetti M, Siewert R. [20 years in the management of reflux disease using fundoplication]. Chirurg. 1977 Oct. 48(10):634-9. [QxMD MEDLINE Link].

43. Kazerooni NL, VanCamp J, Hirschl RB, Drongowski RA, Coran AG. Fundoplication in 160 children under 2 years of age. J Pediatr Surg. 1994 May. 29(5):677-81. [QxMD MEDLINE Link].

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45. Nilsson G, Larsson S, Johnsson F. Randomized clinical trial of laparoscopic versus open fundoplication: blind evaluation of recovery and discharge period. Br J Surg. 2000 Jul. 87(7):873-8. [QxMD MEDLINE Link].

46. Wenner J, Nilsson G, Oberg S, Melin T, Larsson S, Johnsson F. Short-term outcome after laparoscopic and open 360 degrees fundoplication. A prospective randomized trial. Surg Endosc. 2001 Oct. 15(10):1124-8. [QxMD MEDLINE Link].

47. Somme S, Rodriguez JA, Kirsch DG, Liu DC. Laparoscopic versus open fundoplication in infants. Surg Endosc. 2002 Jan. 16(1):54-6. [QxMD MEDLINE Link].

48. Rangel SJ, Henry MC, Brindle M, Moss RL. Small evidence for small incisions: pediatric laparoscopy and the need for more rigorous evaluation of novel surgical therapies. J Pediatr Surg. 2003 Oct. 38(10):1429-33. [QxMD MEDLINE Link].

49. Rothenberg SS. The first decade's experience with laparoscopic Nissen fundoplication in infants and children. J Pediatr Surg. 2005 Jan. 40(1):142-6; discussion 147. [QxMD MEDLINE Link].

50. Pascoe E, Falvey T, Jiwane A, Henry G, Krishnan U. Outcomes of fundoplication for paediatric gastroesophageal reflux disease. Pediatr Surg Int. 2016 Apr. 32(4):353-61. [QxMD MEDLINE Link].

51. Lundell L, Miettinen P, Myrvold HE, et al. Continued (5-year) followup of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg. 2001 Feb. 192(2):172-9; discussion 179-81. [QxMD MEDLINE Link].

52. Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion. 1992. 51 suppl 1:24-9. [QxMD MEDLINE Link].

53. Anvari M, Allen C, Marshall J, et al. A randomized controlled trial of laparoscopic Nissen fundoplication versus proton pump inhibitors for treatment of patients with chronic gastroesophageal reflux disease: One-year follow-up. Surg Innov. 2006 Dec. 13(4):238-49. [QxMD MEDLINE Link].

54. Grant AM, Wileman SM, Ramsay CR, et al. Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial. BMJ. 2008 Dec 15. 337:a2664. [QxMD MEDLINE Link]. [Full Text].

55. El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007 Jan. 5(1):17-26. [QxMD MEDLINE Link].

56. Grant AM, Cotton SC, Boachie C, et al. Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX). BMJ. 2013 Apr 18. 346:f1908. [QxMD MEDLINE Link]. [Full Text].

57. Rebecchi F, Allaix ME, Giaccone C, Ugliono E, Scozzari G, Morino M. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg. 2014 Nov. 260(5):909-14; discussion 914-5. [QxMD MEDLINE Link].

58. Oor JE, Roks DJ, Unlu C, Hazebroek EJ. Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Surg. 2016 Jan. 211(1):250-67. [QxMD MEDLINE Link].

59. US Food and Drug Administration. FDA approves LINX Reflux Management System to treat gastroesophageal reflux disease. Available at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm296923.htm.

60. Zhang H, Dong D, Liu Z, He S, Hu L, Lv Y. Revaluation of the efficacy of magnetic sphincter augmentation for treating gastroesophageal reflux disease. Surg Endosc. 2016 Sep. 30(9):3684-90. [QxMD MEDLINE Link].

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62. [Guideline] Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG Clinical Guideline for the Diagnosis anCG Clinical guideline for the diagnosis and management of gastroesophageal reflux diseased Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 2022 Jan 1. 117 (1):27-56. [QxMD MEDLINE Link]. [Full Text].

63. Kramer JR, Shakhatreh MH, Naik AD, Duan Z, El-Serag HB. Use and yield of endoscopy in patients with uncomplicated gastroesophageal reflux disorder. JAMA Intern Med. 2014 Mar. 174(3):462-5. [QxMD MEDLINE Link].

64. Mattioli S, Lugaresi ML, Di Simone MP, et al. The surgical treatment of the intrathoracic migration of the gastro-oesophageal junction and of short oesophagus in gastro-oesophageal reflux disease. Eur J Cardiothorac Surg. 2004 Jun. 25(6):1079-88. [QxMD MEDLINE Link].

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73. [Guideline] Gyawali CP, Carlson DA, Chen JW, Patel A, Wong RJ, Yadlapati RH. ACG clinical guidelines: clinical use of esophageal physiologic testing. Am J Gastroenterol. 2020 Sep. 115(9):1412-28. [QxMD MEDLINE Link]. [Full Text].

Marco G Patti, MD Surgeon, UNC Hospitals Multispecialty Surgery Clinic

Marco G Patti, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Surgeons, American Gastroenterological Association, American Medical Association, American Surgical Association, Association for Academic Surgery, Pan-Pacific Surgical Association, Society for Surgery of the Alimentary Tract, Society of American Gastrointestinal and Endoscopic Surgeons, Southwestern Surgical Congress, Western Surgical Association

Disclosure: Nothing to disclose.

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Piero Marco Fisichella, MD Assistant Professor of Surgery, Stritch School of Medicine, Loyola University; Director, Esophageal Motility Center, Loyola University Medical Center.

Piero Marco Fisichella is a member of the following medical societies: American College of Surgeons, American Medical Association, Association for Academic Surgery, Society for Surgery of the Alimentary Tract, and Society of American Gastrointestinal and Endoscopic Surgeons

Disclosure: Nothing to disclose.

Fernando AM Herbella, MD, PhD, TCBC Affiliate Professor, Attending Surgeon in Gastrointestinal Surgery, Esophagus and Stomach Division, Department of Surgery, Federal University of Sao Paulo, Brazil; Private Practice; Medical Examiner, Sao Paulo's Medical Examiner's Office Headquarters, Brazil

Fernando AM Herbella, MD, PhD, TCBC is a member of the following medical societies: Society for Surgery of the Alimentary Tract

Disclosure: Nothing to disclose.

John Gunn Lee, MD Director of Pancreaticobiliary Service, Associate Professor, Department of Internal Medicine, Division of Gastroenterology, University of California at Irvine School of Medicine

John Gunn Lee, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Thomas F Murphy, MD Chief of Abdominal Imaging Section, Department of Radiology, Tripler Army Medical Center

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Manish K Varma, MD Chief of Interventional Radiology, Department of Radiology, Tripler Army Medical Center

Manish K Varma, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, and Radiological Society of North America

Disclosure: Nothing to disclose.

Noel Williams, MD Professor Emeritus, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; Professor, Department of Internal Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

Noel Williams, MD is a member of the following medical societies: Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

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