Hepatic Hemangiomas Questions & Answers

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17. Tsai MC, Liu HC, Yeung CY. Efficacy of infantile hepatic hemangioma with propranolol treatment: A case report. Medicine (Baltimore). 2019 Jan. 98 (4):e14078. [QxMD MEDLINE Link]. [Full Text].

18. Yang K, Peng S, Chen L, Chen S, Ji Y. Efficacy of propranolol treatment in infantile hepatic haemangioma. J Paediatr Child Health. 2019 Jan 9. [QxMD MEDLINE Link].

19. Huang SA, Tu HM, Harney JW, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med. 2000 Jul 20. 343(3):185-9. [QxMD MEDLINE Link].

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21. Goodman Z. Benign tumors of the liver. Okuda K, Ishak KG. Neoplasms of the liver. Tokyo: Springer-Verlag; 1987. 105-25.

22. Hasan HY, Hinshaw JL, Borman EJ, Gegios A, Leverson G, Winslow ER. Assessing normal growth of hepatic hemangiomas during long-term follow-up. JAMA Surg. 2014 Dec. 149(12):1266-71. [QxMD MEDLINE Link].

23. Jing L, Liang H, Caifeng L, et al. New recognition of the natural history and growth pattern of hepatic hemangioma in adults. Hepatol Res. 2016 Jul. 46(8):727-33. [QxMD MEDLINE Link].

24. Mikami T, Hirata K, Oikawa I, et al. Hemobilia caused by a giant benign hemangioma of the liver: report of a case. Surg Today. 1998. 28(9):948-52. [QxMD MEDLINE Link].

25. Lee CW, Chung YH, Lee GC, et al. A case of giant hemangioma of the liver presenting with fever of unknown origin. J Korean Med Sci. 1994 Apr. 9(2):200-4. [QxMD MEDLINE Link].

26. Pol B, Disdier P, Le Treut YP, et al. Inflammatory process complicating giant hemangioma of the liver: report of three cases. Liver Transpl Surg. 1998 May. 4(3):204-7. [QxMD MEDLINE Link].

27. Brannigan M, Burns PN, Wilson SR. Blood flow patterns in focal liver lesions at microbubble-enhanced US. Radiographics. 2004 Jul-Aug. 24(4):921-35. [QxMD MEDLINE Link].

28. Dietrich CF, Mertens JC, Braden B, et al. Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology. 2007 May. 45(5):1139-45. [QxMD MEDLINE Link].

29. von Herbay A, Vogt C, Willers R, et al. Real-time imaging with the sonographic contrast agent SonoVue: differentiation between benign and malignant hepatic lesions. J Ultrasound Med. 2004 Dec. 23(12):1557-68. [QxMD MEDLINE Link].

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32. Vossen JA, Buijs M, Liapi E, Eng J, Bluemke DA, Kamel IR. Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions. J Comput Assist Tomogr. 2008 Sep-Oct. 32(5):750-6. [QxMD MEDLINE Link]. [Full Text].

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35. Obata S, Matsunaga N, Hayashi K, et al. Fluid-fluid levels in giant cavernous hemangioma of the liver: CT and MRI demonstration. Abdom Imaging. 1998 Nov-Dec. 23(6):600-2. [QxMD MEDLINE Link].

36. Duran R, Ronot M, Di Renzo S, Gregoli B, Van Beers BE, Vilgrain V. Is magnetic resonance imaging of hepatic hemangioma any different in liver fibrosis and cirrhosis compared to normal liver?. Eur J Radiol. 2015 May. 84(5):816-22. [QxMD MEDLINE Link].

37. Kinnard MF, Alavi A, Rubin RA, et al. Nuclear imaging of solid hepatic masses. Semin Roentgenol. 1995 Oct. 30(4):375-95. [QxMD MEDLINE Link].

38. Krause T, Hauenstein K, Studier-Fischer B, et al. Improved evaluation of technetium-99m-red blood cell SPECT in hemangioma of the liver. J Nucl Med. 1993 Mar. 34(3):375-80. [QxMD MEDLINE Link].

39. Tsai CC, Yen TC, Tzen KY. Pedunculated giant liver hemangioma mimicking a hypervascular gastric tumor on Tc-99m RBC SPECT. Clin Nucl Med. 1999 Feb. 24(2):132-3. [QxMD MEDLINE Link].

40. De Franco A, Monteforte MG, Maresca G, et al. [Integrated diagnosis of liver angioma: comparison of Doppler color ultrasonography, computerized tomography, and magnetic resonance]. Radiol Med. 1997 Jan-Feb. 93(1-2):87-94. [QxMD MEDLINE Link].

41. Okano A, Sonoyama H, Masano Y, et al. The natural history of a hepatic angiosarcoma that was difficult to differentiate from cavernous hemangioma. Intern Med. 2012. 51(20):2899-904. [QxMD MEDLINE Link].

42. Heo SH, Jeong YY, Shin SS, Chung TW, Kang HK. Solitary small hepatic angiosarcoma: initial and follow-up imaging findings. Korean J Radiol. 2007 Mar-Apr. 8(2):180-3. [QxMD MEDLINE Link]. [Full Text].

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44. Heilo A, Stenwig AE. Liver hemangioma: US-guided 18-gauge core-needle biopsy. Radiology. 1997 Sep. 204(3):719-22. [QxMD MEDLINE Link].

45. Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 2001 Sep. 35(3):421-30. [QxMD MEDLINE Link].

46. Craig JR, Peters RL, Edmondson HA. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology. Washington, D.C.: Armed Forces Institute of Pathology; 1989. Second series, fasc. 26: 56-62.

47. Ishak KG, Markin RS. Liver. Damjanov I, Linder J, eds. Anderson's Pathology. 10th ed. Mosby: St. Louis, Mo; 1996. 1834.

48. Gibney RG, Hendin AP, Cooperberg PL. Sonographically detected hepatic hemangiomas: absence of change over time. AJR Am J Roentgenol. 1987 Nov. 149(5):953-7. [QxMD MEDLINE Link].

49. Mahajan D, Miller C, Hirose K, McCullough A, Yerian L. Incidental reduction in the size of liver hemangioma following use of VEGF inhibitor bevacizumab. J Hepatol. 2008 Nov. 49(5):867-70. [QxMD MEDLINE Link].

50. Yamashita S, Okita K, Harada K, et al. Giant cavernous hepatic hemangioma shrunk by use of sorafenib. Clin J Gastroenterol. 2013 Feb. 6(1):55-62. [QxMD MEDLINE Link]. [Full Text].

51. Miura JT, Amini A, Schmocker R, et al. Surgical management of hepatic hemangiomas: a multi-institutional experience. HPB (Oxford). 2014 Oct. 16(10):924-8. [QxMD MEDLINE Link].

52. Belli G, D'Agostino A, Fantini C, et al. Surgical treatment of giant liver hemangiomas by enucleation using an ultrasonically activated device (USAD). Hepatogastroenterology. 2009 Jan-Feb. 56(89):236-9. [QxMD MEDLINE Link].

53. Mocchegiani F, Vincenzi P, Coletta M, et al. Prevalence and clinical outcome of hepatic haemangioma with specific reference to the risk of rupture: A large retrospective cross-sectional study. Dig Liver Dis. 2016 Mar. 48(3):309-14. [QxMD MEDLINE Link].

54. Jain V, Ramachandran V, Garg R, Pal S, Gamanagatti SR, Srivastava DN. Spontaneous rupture of a giant hepatic hemangioma - sequential management with transcatheter arterial embolization and resection. Saudi J Gastroenterol. 2010 Apr-Jun. 16(2):116-9. [QxMD MEDLINE Link]. [Full Text].

55. Corigliano N, Mercantini P, Amodio PM, et al. Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. Surg Today. 2003. 33(6):459-63. [QxMD MEDLINE Link].

56. Ribeiro MAF, Papaiordanou F, Goncalves JM, Chaib E. Spontaneous rupture of hepatic hemangiomas: A review of the literature. World J Hepatol. 2010 Dec 27. 2(12):428-33. [QxMD MEDLINE Link]. [Full Text].

57. Donati M, Stavrou GA, Donati A, Oldhafer KJ. The risk of spontaneous rupture of liver hemangiomas: a critical review of the literature. J Hepatobiliary Pancreat Sci. 2011 Nov. 18(6):797-805. [QxMD MEDLINE Link].

58. Plackett TP, Lin-Hurtubise KM. Hepatic hemangiomas and parachuting. Aviat Space Environ Med. 2008 Oct. 79(10):986-8. [QxMD MEDLINE Link].

59. Schnelldorfer T, Ware AL, Smoot R, Schleck CD, Harmsen WS, Nagorney DM. Management of giant hemangioma of the liver: resection versus observation. J Am Coll Surg. 2010 Dec. 211(6):724-30. [QxMD MEDLINE Link].

60. Arnoletti JP, Brodsky J. Surgical treatment of benign hepatic mass lesions. Am Surg. 1999 May. 65(5):431-3. [QxMD MEDLINE Link].

61. Fu XH, Lai EC, Yao XP, et al. Enucleation of liver hemangiomas: is there a difference in surgical outcomes for centrally or peripherally located lesions?. Am J Surg. 2009 Aug. 198(2):184-7. [QxMD MEDLINE Link].

62. Zhu H, Obeidat K, Ouyang J, Roayaie S, Schwartz ME, Thung SN. Recurrent giant hemangiomas of liver: Report of two rare cases with literature review. World J Gastrointest Surg. 2012 Nov 27. 4(11):262-6. [QxMD MEDLINE Link]. [Full Text].

63. Deutsch GS, Yeh KA, Bates WB 3rd, Tannehill WB. Embolization for management of hepatic hemangiomas. Am Surg. 2001 Feb. 67(2):159-64. [QxMD MEDLINE Link].

64. Srivastava DN, Gandhi D, Seith A, et al. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. Abdom Imaging. 2001 Sep-Oct. 26(5):510-4. [QxMD MEDLINE Link].

65. Zeng Q, Li Y, Chen Y, et al. Gigantic cavernous hemangioma of the liver treated by intra-arterial embolization with pingyangmycin-lipiodol emulsion: a multi-center study. Cardiovasc Intervent Radiol. 2004 Sep-Oct. 27(5):481-5. [QxMD MEDLINE Link].

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67. Rokitansky AM, Jakl RJ, Gopfrich H, et al. Special compression sutures: a new surgical technique to achieve a quick decrease in shunt volume caused by diffuse hemangiomatosis of the liver. Pediatr Surg Int. 1998 Nov. 14(1-2):119-21. [QxMD MEDLINE Link].

68. Hinshaw JL, Laeseke PJ, Weber SM, Lee FT Jr. Multiple-electrode radiofrequency ablation of symptomatic hepatic cavernous hemangioma. AJR Am J Roentgenol. 2007 Sep. 189(3):W146-9. [QxMD MEDLINE Link].

69. Park SY, Tak WY, Jung MK, et al. Symptomatic-enlarging hepatic hemangiomas are effectively treated by percutaneous ultrasonography-guided radiofrequency ablation. J Hepatol. 2011 Mar. 54(3):559-65. [QxMD MEDLINE Link].

70. Fan RF, Chai FL, He GX, et al. Laparoscopic radiofrequency ablation of hepatic cavernous hemangioma. A preliminary experience with 27 patients. Surg Endosc. 2006 Feb. 20(2):281-5. [QxMD MEDLINE Link].

71. van Tilborg AA, Nielsen K, Scheffer HJ, et al. Bipolar radiofrequency ablation for symptomatic giant (>10 cm) hepatic cavernous haemangiomas: initial clinical experience. Clin Radiol. 2013 Jan. 68(1):e9-e14. [QxMD MEDLINE Link].

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73. Gaspar L, Mascarenhas F, da Costa MS, Dias JS, Afonso JG, Silvestre ME. Radiation therapy in the unresectable cavernous hemangioma of the liver. Radiother Oncol. 1993 Oct. 29(1):45-50. [QxMD MEDLINE Link].

74. Biswal BM, Sandhu M, Lal P, et al. Role of radiotherapy in cavernous hemangioma liver. Indian J Gastroenterol. 1995 Jul. 14(3):95-8. [QxMD MEDLINE Link].

75. Tepetes K, Selby R, Webb M, et al. Orthotopic liver transplantation for benign hepatic neoplasms. Arch Surg. 1995 Feb. 130(2):153-6. [QxMD MEDLINE Link].

76. Vagefi PA, Klein I, Gelb B, et al. Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review. J Gastrointest Surg. 2011 Jan. 15(1):209-14. [QxMD MEDLINE Link]. [Full Text].

77. Okano A, Sonoyama H, Masano Y, et al. The natural history of a hepatic angiosarcoma that was difficult to differentiate from cavernous hemangioma. Intern Med. 2012. 51(20):2899-904. [QxMD MEDLINE Link].

78. Ozmen E, Adaletli I, Kayadibi Y, et al. The impact of share wave elastography in differentiation of hepatic hemangioma from malignant liver tumors in pediatric population. Eur J Radiol. 2014 Sep. 83(9):1691-7. [QxMD MEDLINE Link].

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80. Hardie AD, Egbert RE, Rissing MS. Improved differentiation between hepatic hemangioma and metastases on diffusion-weighted MRI by measurement of standard deviation of apparent diffusion coefficient. Clin Imaging. 2015 Jul-Aug. 39(4):654-8. [QxMD MEDLINE Link].

81. Kumar N, Adam SZ, Goodhartz LA, Hoff FL, Lo AA, Miller FH. Beyond hepatic hemangiomas: the diverse appearances of gastrointestinal and genitourinary hemangiomas. Abdom Imaging. 2015 Oct. 40(8):3313-29. [QxMD MEDLINE Link].

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David C Wolf, MD, FACP, FACG, AGAF, FAASLD Medical Director of Liver Transplantation, Westchester Medical Center; Professor of Clinical Medicine, Division of Gastroenterology and Hepatobiliary Diseases, Department of Medicine, New York Medical College

David C Wolf, MD, FACP, FACG, AGAF, FAASLD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Salix; Gilead; Abbvie; Intercept; Merck.

Unnithan V Raghuraman, MD, FACG, FACP, FRCP Consulting Staff, Department of Gastroenterology, St John Medical Center

Unnithan V Raghuraman, MD, FACG, FACP, FRCP is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Vivek V Gumaste, MD Associate Professor of Medicine, Mount Sinai School of Medicine of New York University; Adjunct Clinical Assistant, Mount Sinai Hospital; Director, Division of Gastroenterology, City Hospital Center at Elmhurst; Program Director of GI Fellowship (Independent Program); Regional Director of Gastroenterology, Queens Health Network

Vivek V Gumaste, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association

Disclosure: Nothing to disclose.

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