Acute Liver Failure Differential Diagnoses

Updated: Jun 13, 2017
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Diagnostic Considerations

A wide variety of conditions can cause acute liver failure or produce mental status changes and coagulopathy resembling acute liver failure. Problems to consider include the following:

  • Acute fatty liver of pregnancy
  • Amanita phalloides mushroom poisoning
  • Bacillus cereus toxin
  • Fructose intolerance
  • Galactosemia
  • HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome of pregnancy
  • Hemorrhagic viruses (Ebola virus, Lassa virus, Marburg virus)
  • Idiopathic drug reaction (hypersensitivity)
  • Neonatal iron storage disease
  • Tyrosinemia
  • Acetaminophen poisoning

For a discussion of acute liver failure and other diagnostic considerations in liver transplant recipients, see the Medscape article Liver Transplants.

Differential Diagnoses