Hepatitis D Differential Diagnoses

1. Rizzetto M, Verme G. Delta hepatitis--present status. J Hepatol. 1985. 1(2):187-93. [QxMD MEDLINE Link].

2. Bean P. Latest discoveries on the infection and coinfection with hepatitis D virus. Am Clin Lab. 2002 Jun. 21(5):25-7. [QxMD MEDLINE Link].

3. Xiridou M, Borkent-Raven B, Hulshof J, Wallinga J. How hepatitis D virus can hinder the control of hepatitis B virus. PLoS One. 2009. 4(4):e5247. [QxMD MEDLINE Link]. [Full Text].

4. Abbas Z, Afzal R. Life cycle and pathogenesis of hepatitis D virus: a review. World J Hepatol. 2013 Dec 27. 5(12):666-75. [QxMD MEDLINE Link].

5. Smedile A, Casey JL, Cote PJ, et al. Hepatitis D viremia following orthotopic liver transplantation involves a typical HDV virion with a hepatitis B surface antigen envelope. Hepatology. 1998 Jun. 27(6):1723-9. [QxMD MEDLINE Link].

6. Samuel D, Zignego AL, Reynes M, et al. Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis. Hepatology. 1995 Feb. 21(2):333-9. [QxMD MEDLINE Link].

7. Romeo R, Del Ninno E, Rumi M, et al. A 28-year study of the course of hepatitis delta infection: a risk factor for cirrhosis and hepatocellular carcinoma. Gastroenterology. 2009 May. 136(5):1629-38. [QxMD MEDLINE Link].

8. Bahcecioglu IH, Sahin A. Treatment of delta hepatitis: today and in the future - a review. Infect Dis (Lond). 2017 Apr. 49(4):241-50. [QxMD MEDLINE Link].

9. Bockmann JH, Grube M, Hamed V, et al. High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: longitudinal analysis of a German cohort. BMC Gastroenterol. 2020 Jan 30. 20(1):24. [QxMD MEDLINE Link]. [Full Text].

10. Rizzetto M, Hamid S, Negro F. The changing context of hepatitis D. J Hepatol. 2021 May. 74(5):1200-11. [QxMD MEDLINE Link]. [Full Text].

11. Vlachogiannakos J, Papatheodoridis GV. New epidemiology of hepatitis delta. Liver Int. 2020 Feb. 40 suppl 1:48-53. [QxMD MEDLINE Link].

12. Mallet V, Hamed K, Schwarzinger M. Prognosis of patients with chronic hepatitis B in France (2008-2013): A nationwide, observational and hospital-based study. J Hepatol. 2017 Mar. 66(3):514-20. [QxMD MEDLINE Link].

13. Alfaiate D, Lucifora J, Abeywickrama-Samarakoon N, et al. HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes. Antiviral Res. 2016 Dec. 136:19-31. [QxMD MEDLINE Link].

14. Da BL, Rahman F, Lai WC, Kleiner DE, Heller T, Koh C. Risk factors for delta hepatitis in a North American cohort: who should be screened?. Am J Gastroenterol. 2021 Jan 1. 116(1):206-9. [QxMD MEDLINE Link].

15. Alfaiate D, Deny P, Durantel D. Hepatitis delta virus: from biological and medical aspects to current and investigational therapeutic options. Antiviral Res. 2015 Oct. 122:112-29. [QxMD MEDLINE Link].

16. Braga WS, Castilho Mda C, Borges FG, et al. Hepatitis D virus infection in the Western Brazilian Amazon - far from a vanishing disease. Rev Soc Bras Med Trop. 2012 Dec. 45(6):691-5. [QxMD MEDLINE Link].

17. Heidrich B, Deterding K, Tillmann HL, Raupach R, Manns MP, Wedemeyer H. Virological and clinical characteristics of delta hepatitis in Central Europe. J Viral Hepat. 2009 Dec. 16(12):883-94. [QxMD MEDLINE Link].

18. Makuwa M, Mintsa-Ndong A, Souquiere S, Nkoghe D, Leroy EM, Kazanji M. Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa. J Clin Microbiol. 2009 Jul. 47(7):2265-8. [QxMD MEDLINE Link]. [Full Text].

19. Ordieres C, Navascues CA, Gonzalez-Dieguez ML, et al. Prevalence and epidemiology of hepatitis D among patients with chronic hepatitis B virus infection: a report from Northern Spain. Eur J Gastroenterol Hepatol. 2017 Mar. 29(3):277-83. [QxMD MEDLINE Link].

20. Goyal A, Murray JM. Recognizing the impact of endemic hepatitis D virus on hepatitis B virus eradication. Theor Popul Biol. 2016 Dec. 112:60-9. [QxMD MEDLINE Link].

21. Shah PA, Choudhry S, Reyes KJC, Lau DTY. An update on the management of chronic hepatitis D. Gastroenterol Rep (Oxf). 2019 Dec. 7(6):396-402. [QxMD MEDLINE Link]. [Full Text].

22. Kodani M, Martin A, Mixson-Hayden T, Drobeniuc J, Gish RR, Kamili S. One-step real-time PCR assay for detection and quantitation of hepatitis D virus RNA. J Virol Methods. 2013 Nov. 193(2):531-5. [QxMD MEDLINE Link].

23. Buchmann B, Dohner K, Schirdewahn T, et al. A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection. Antiviral Res. 2017 Feb 20. 141:116-23. [QxMD MEDLINE Link].

24. European Medicines Agency. Hepcludex (EMEA/H/C/004854). Available at https://www.ema.europa.eu/en/medicines/human/EPAR/hepcludex. August 12, 2020. Updated: October 7, 2020; Accessed: January 25, 2021.

25. Highleyman L. Bulevirtide shows promise as maintenance therapy for hepatitis D. InfoHep.org. August 30, 2020. Available at http://www.infohep.org/page/3549039.

26. Petersen J, Thompson AJ, Levrero M. Aiming for cure in HBV and HDV infection. J Hepatol. 2016 Oct. 65(4):835-48. [QxMD MEDLINE Link].

27. Abeywickrama-Samarakoon N, Cortay JC, Deny P. The hepatitis D satellite virus of hepatitis B virus: half-opening a new era to control viral infection?. Curr Opin Infect Dis. 2016 Dec. 29(6):645-53. [QxMD MEDLINE Link].

28. Wedemeyer H, Yurdaydin C, Dalekos GN, et al. Peginterferon plus adefovir versus either drug alone for hepatitis delta. N Engl J Med. 2011 Jan 27. 364(4):322-31. [QxMD MEDLINE Link].

29. Samiullah S, Bikharam D, Nasreen. Treatment of chronic hepatitis delta virus with peg-interferon and factors that predict sustained viral response. World J Gastroenterol. 2012 Oct 28. 18(40):5793-8. [QxMD MEDLINE Link].

30. Abdrakhman A, Ashimkhanova A, Almawi WY. Effectiveness of pegylated interferon monotherapy in the treatment of chronic hepatitis D virus infection: A meta-analysis. Antiviral Res. 2021 Jan. 185:104995. [QxMD MEDLINE Link].

31. Maravelia P, Frelin L, Ni Y, et al. Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections. J Infect Dis. 2021 Jan 4. 223(1):128-38. [QxMD MEDLINE Link]. [Full Text].

32. Deterding K, Wedemeyer H. Beyond pegylated Interferon-alpha: new treatments for hepatitis delta. AIDS Rev. 2019. 21(3):126-34. [QxMD MEDLINE Link].

33. Manesis EK, Schina M, Le Gal F, et al. Quantitative analysis of hepatitis D virus RNA and hepatitis B surface antigen serum levels in chronic delta hepatitis improves treatment monitoring. Antivir Ther. 2007. 12(3):381-8. [QxMD MEDLINE Link].

34. Suvak B, Dulger AC, Suvak O, Yesilyurt AO, Gultepe B, Guducuoglu H. The prevalence and impact of brucellosis in patients with hepatitis delta virus infection: inside the Brucella outbreak with cirrhosis. Arch Med Sci. 2017 Mar 1. 13(2):377-82. [QxMD MEDLINE Link]. [Full Text].

35. Gu XH, Chen Z, Dai RY, et al. Analysis on the clinical features of 507 HDV-infected patients. Cell Biochem Biophys. 2014 Dec. 70(3):1829-32. [QxMD MEDLINE Link].

36. Huang CR, Lo SJ. Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus. World J Gastroenterol. 2014 Oct 28. 20(40):14589-97. [QxMD MEDLINE Link]. [Full Text].

37. Keskin O, Wedemeyer H, Tuzun A, et al. Association between level of hepatitis D virus RNA at week 24 of pegylated interferon therapy and outcome. Clin Gastroenterol Hepatol. 2015 Dec. 13(13):2342-49.e1-2. [QxMD MEDLINE Link].

Praveen K Roy, MD, MSc Clinical Assistant Professor of Medicine, University of New Mexico School of Medicine

Praveen K Roy, MD, MSc is a member of the following medical societies: Alaska State Medical Association, American Gastroenterological Association

Disclosure: Nothing to disclose.

Rahaman Mujibur, MD Academic Hospitalist/Hospitalist, Marshfield Clinic, St Joseph’s Hospital

Rahaman Mujibur, MD is a member of the following medical societies: American College of Physicians, American Medical Association, Wisconsin Medical Society

Disclosure: Nothing to disclose.

Rajan Kanth, MD Gastroenterologist, WellSpan Health

Rajan Kanth, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, Nepal Medical Association, Society of Hospital Medicine

Disclosure: Nothing to disclose.

Sean R Lacey, MD Associate Professor of Gastroenterology, Pennsylvania State University College of Medicine; Staff Physician, Division of Gastroenterology, Lehigh Valley Hospital and St Luke's Hospital

Sean R Lacey, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association

Disclosure: Nothing to disclose.

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

David Eric Bernstein, MD Director of Hepatology, North Shore University Hospital; Professor of Clinical Medicine, Albert Einstein College of Medicine

David Eric Bernstein, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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