Hepatitis D Medication

Updated: Oct 20, 2021
  • Author: Praveen K Roy, MD, MSc; Chief Editor: BS Anand, MD  more...
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Medication Summary

Antiviral therapy with interferon alfa can be considered in patients with chronic hepatitis D virus (HDV) infection. The treatment course is usually at least 1 year. Treating children with interferon alfa seems to be safe but is relatively ineffective. Treatment is not needed for patients with coinfection, given the high spontaneous clearance rates. Lamivudine, ribavirin, and corticosteroids have not been effective in treatment.



Class Summary

These are naturally produced proteins with antiviral, antitumor, and immunomodulatory actions.

Interferon alfa-2a (Roferon)

Interferon alfa-2a has been used in several small studies to treat hepatitis D virus (HDV) infection. Dosages varying from 3-10 mU 3 times per week for as long as 12 months have been used. At the end of therapy, loss of HDV RNA and normalization of liver enzymes was seen in 50% of patients treated with 9 mU 3 times per week and in 21% in those treated with 3 mU. Half the responders remained in biochemical remission after the cessation of therapy, while no patients maintained a virologic response after cessation. Histologic improvement was observed in patients treated with interferon.