Conjugated Hyperbilirubinemia Questions & Answers

Updated: Aug 31, 2021
  • Author: Heba Rashid Ashraf, MD; Chief Editor: BS Anand, MD  more...
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Questions & Answers

Overview

What causes conjugated hyperbilirubinemia?

Which diseases cause conjugated hyperbilirubinemia?

How is conjugated hyperbilirubinemia diagnosed?

What is the difference between direct and indirect bilirubin?

What is the role of the kidneys in the etiology of conjugated hyperbilirubinemia?

What are normal bilirubin levels?

What is the pathophysiology of conjugated hyperbilirubinemia?

What are the most common etiologies of conjugated hyperbilirubinemia?

What are the most common diseases that cause conjugated hyperbilirubinemia?

What is the prevalence of conjugated hyperbilirubinemia in the US?

What is the global prevalence of conjugated hyperbilirubinemia?

How does the prevalence of conjugated hyperbilirubinemia vary by sex and race?

How does the prevalence of conjugated hyperbilirubinemia vary by age?

What is the morbidity and the mortality associated with conjugated hyperbilirubinemia?

Presentation

What is the focus of clinical history in suspected conjugated hyperbilirubinemia?

What are risk factors for viral hepatitis-related conjugated hyperbilirubinemia?

What are the signs and symptoms of conjugated hyperbilirubinemia?

What are physical manifestations of conjugated hyperbilirubinemia?

Which findings of abdominal palpation suggest conjugated hyperbilirubinemia?

Which findings of biliary obstructions suggest conjugated hyperbilirubinemia?

Which physical findings suggest hemochromatosis?

What is the significance of a finding of Kaiser-Fleisher rings in the evaluation of conjugated hyperbilirubinemia?

Which findings may suggest a chronic alcoholism etiology for conjugated hyperbilirubinemia?

DDX

What is essential when diagnosing conjugated hyperbilirubinemia?

Which conditions should be considered in the differential diagnosis of suspected conjugated hyperbilirubinemia?

What are the differential diagnoses for Conjugated Hyperbilirubinemia?

Workup

What is the role of clinical history in the selection of initial lab tests for diagnosis of conjugated hyperbilirubinemia?

Which lab studies are necessary for the diagnosis of conjugated hyperbilirubinemia?

What is the role of fractionated bilirubin levels in the diagnosis of conjugated hyperbilirubinemia?

When are serum total and conjugated bilirubin levels indicated for the diagnosis of conjugated hyperbilirubinemia?

When is a liver biopsy indicated for the diagnosis of conjugated hyperbilirubinemia?

How is biliary atresia diagnosed in patients with conjugated hyperbilirubinemia?

What is the role of ultrasonography in the diagnosis of conjugated hyperbilirubinemia?

What is the role of CT scanning in the diagnosis of conjugated hyperbilirubinemia?

What are the advantages of CT scanning for the diagnosis of conjugated hyperbilirubinemia?

What are the disadvantages of CT scanning for the diagnosis of conjugated hyperbilirubinemia?

What is the role of MRI in the diagnosis of conjugated hyperbilirubinemia?

What are the advantages of MRI for the diagnosis of conjugated hyperbilirubinemia?

What are the disadvantages of MRI for the diagnosis of conjugated hyperbilirubinemia?

What is the role of endoscopic retrograde cholangiopancreatography (ERCP) in the diagnosis of conjugated hyperbilirubinemia?

What are the advantages of ERCP for the diagnosis of conjugated hyperbilirubinemia?

What are the disadvantages of ERCP for the diagnosis of conjugated hyperbilirubinemia?

What is the role of percutaneous transhepatic cholangiography (PTC or PTHC) in the diagnosis of conjugated hyperbilirubinemia?

What are the advantages of percutaneous transhepatic cholangiography (PTC or PTHC) for the diagnosis of conjugated hyperbilirubinemia?

What are the disadvantages of percutaneous transhepatic cholangiography (PTC or PTHC) for the diagnosis of conjugated hyperbilirubinemia?

Treatment

What are the treatment options for conjugated hyperbilirubinemia?

Which specialist consultations are needed for the management of conjugated hyperbilirubinemia?