Conjugated Hyperbilirubinemia Treatment & Management

Updated: Aug 31, 2021
  • Author: Heba Rashid Ashraf, MD; Chief Editor: BS Anand, MD  more...
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Approach Considerations

Treatment of conjugated hyperbilirubinemia is dependent on the cause; it may include supportive or curative measures. [15]

Failure to diagnose liver toxicity due to ongoing drug or toxin exposure may lead to liver failure and death. For this reason, it is best to stop all potentially hepatotoxic drugs until the cause of the conjugated hyperbilirubinemia can be determined.


In most patients, the cause of conjugated hyperbilirubinemia is apparent, such as those with viral hepatitis or sepsis. When this is not the case or when multiple causes are possible, consultation with a gastroenterologist or a hepatologist may be helpful.