Pediatric Lipid Disorders in Clinical Practice Differential Diagnoses

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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DDx

Diagnostic Considerations

Measure the fasting lipid profile twice and average the results if any of the following are noted:

  • Family history of premature cardiovascular disease

  • Family history of dyslipidemia

  • Pediatric medical condition that predisposes to cardiovascular disease or dyslipidemia

Pediatric conditions with an increased risk for cardiovascular disease include the following:

  • Lifestyle: Smoking (including exposure to secondary smoke), obesity (body mass index [BMI] > 95th percentile), physical inactivity

  • Metabolic disorders: Diabetes mellitus, low level of high-density lipoprotein cholesterol (HDL-C) (ie, < 35 mg/dL)

  • Hypertension and other underlying conditions or situations: Renal disease (eg, renal failure, renal transplantation), liver disease (eg, biliary tract disease), endocrinopathies (eg, hypothyroidism, Cushing syndrome), use of drugs known to induce dyslipidemias (eg, cyclosporine, glucocorticoids, human immunodeficiency virus [HIV] protease inhibitors)