Protein-Losing Enteropathy Treatment & Management

Updated: Dec 10, 2019
  • Author: Naeem Aslam, MD; Chief Editor: Burt Cagir, MD, FACS  more...
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Medical Care

Focus treatment on correcting the underlying process causing the protein-losing gastroenteropathy. [21] For example, the patient with congestive heart failure may respond to digitalis and diuretics, whereas the patient with intestinal parasites should be treated with the appropriate medication for the infestation.


Surgical Care

Surgery for giant hypertrophic gastropathy (Ménétrier disease) and localized lymphatic obstruction has been suggested. [10] Surgical lymphovenous anastomosis may also be of benefit in these patients.

Eradicating Helicobacter pylori has also been shown to decrease gastric protein loss in some patients with giant hypertrophic gastropathy. [10]



A low-fat diet with supplementation with medium-chain triglycerides is theoretically of benefit in patients with lymphangiectasias. However, in practice, ingesting a diet containing medium-chain triglycerides results in increased blood flow with no reduction in fecal protein loss. [32, 33]

Patients with celiac sprue typically respond to a gluten-free diet. A minority requires corticosteroids.