Hauser RA, Grosset DG. [(123) I]FP-CIT (DaTscan) SPECT Brain Imaging in Patients with Suspected Parkinsonian Syndromes. J Neuroimaging. 2011 Mar 16. [QxMD MEDLINE Link].
Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011 Jun. 26 Suppl 1:S1-58. [QxMD MEDLINE Link].
Anderson P. More Evidence Links Pesticides, Solvents, With Parkinson's. Medscape Medical News. Available at http://www.medscape.com/viewarticle/804834. Accessed: June 11, 2013.
Pezzoli G, Cereda E. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology. 2013 May 28. 80(22):2035-41. [QxMD MEDLINE Link].
Liu R, Guo X, Park Y, Huang X, Sinha R, Freedman ND, et al. Caffeine Intake, Smoking, and Risk of Parkinson Disease in Men and Women. Am J Epidemiol. 2012 Apr 13. [QxMD MEDLINE Link].
Ballard PA, Tetrud JW, Langston JW. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology. 1985 Jul. 35(7):949-56. [QxMD MEDLINE Link].
Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, et al. Parkinson disease in twins: an etiologic study. JAMA. 1999 Jan 27. 281(4):341-6. [QxMD MEDLINE Link].
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997 Jun 27. 276(5321):2045-7. [QxMD MEDLINE Link].
Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet. 1998 Feb. 18(2):106-8. [QxMD MEDLINE Link].
Bekris LM, Mata IF, Zabetian CP. The genetics of Parkinson disease. J Geriatr Psychiatry Neurol. 2010 Dec. 23(4):228-42. [QxMD MEDLINE Link]. [Full Text].
Alcalay RN, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Ross BM, et al. Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch Neurol. 2010 Sep. 67(9):1116-22. [QxMD MEDLINE Link].
Samanta J, Hauser RA. Duodenal levodopa infusion for the treatment of Parkinson's disease. Expert Opin Pharmacother. 2007 Apr. 8(5):657-64. [QxMD MEDLINE Link].
Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L. Pathological roles of a-synuclein in neurological disorders. Lancet Neurol. 2011 Nov. 10(11):1015-25. [QxMD MEDLINE Link].
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med. 2008 May. 14(5):504-6. [QxMD MEDLINE Link].
Dalvin LA, Damento GM, Yawn BP, Abbott BA, Hodge DO, Pulido JS. Parkinson Disease and Melanoma: Confirming and Reexamining an Association. Mayo Clin Proc. 2017 Jul. 92 (7):1070-1079. [QxMD MEDLINE Link].
Mulcahy, N. Melanoma, Parkinson's: See One, Be Aware of the Other. Medscape Medical News. Available at http://www.medscape.com/viewarticle/883195. July 19, 2017; Accessed: July 26, 2017.
Constantinescu R, Elm J, Auinger P, Sharma S, Augustine EF, Khadim L, et al. Malignant melanoma in early-treated Parkinson's disease: the NET-PD trial. Mov Disord. 2014 Feb. 29 (2):263-5. [QxMD MEDLINE Link].
De Pablo-Fernandez E, Goldacre R, Pakpoor J, Noyce AJ, Warner TT. Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study. Neurology. 2018 Jun 13. [QxMD MEDLINE Link].
Muangpaisan W, Mathews A, Hori H, Seidel D. A systematic review of the worldwide prevalence and incidence of Parkinson's disease. J Med Assoc Thai. 2011 Jun. 94(6):749-55. [QxMD MEDLINE Link].
Grimes DA, Lang AE. Treatment of early Parkinsons disease. Can J Neurol Sci. 1999 Aug. 26 Suppl 2:S39-44. [QxMD MEDLINE Link].
Thobois S, Delamarre-Damier F, Derkinderen P. Treatment of motor dysfunction in Parkinsons disease: an overview. Clin Neurol Neurosurg. 2005 Jun. 107(4):269-81. [QxMD MEDLINE Link].
Suchowersky O, Reich S, Perlmutter J, Zesiewicz T, Gronseth G, Weiner WJ. Practice Parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006 Apr 11. 66(7):968-75. [QxMD MEDLINE Link].
National Collaborating Centre for Chronic Conditions. Parkinson's disease: National clinical guideline for diagnosis and management in primary and secondary care. London, UK: Royal College of Physicians; 2006.
Hughes S. Consider Nonmotor Symptoms for Diagnosis of Parkinson's? Medscape Medical News. January 18, 2013. Available at http://www.medscape.com/viewarticle/777874. Accessed: January 22, 2013.
Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O'Brien JT, Brooks DJ, et al. The spectrum of nonmotor symptoms in early Parkinson disease. Neurology. 2013 Jan 15. 80(3):276-81. [QxMD MEDLINE Link].
Simuni T, Sethi K. Nonmotor manifestations of Parkinson's disease. Ann Neurol. 2008 Dec. 64 Suppl 2:S65-80. [QxMD MEDLINE Link].
Sato Y, Iwamoto J, Honda Y. Vitamin D Deficiency-Induced Vertebral Fractures May Cause Stooped Posture in Parkinson Disease. Am J Phys Med Rehabil. 2011 Jan 5. [QxMD MEDLINE Link].
Brin MF, Velickovic M, Remig LO. Dysphonia due to Parkinson's disease; pharmacological, surgical, and behavioral management perspectives. Vocal Rehabilitation in Medical Speech-Language Pathology. Austin: Pro-Ed; 2004. 209-69.
Perez KS, Ramig LO, Smith ME, Dromey C. The Parkinson larynx: tremor and videostroboscopic findings. J Voice. 1996 Dec. 10(4):354-61. [QxMD MEDLINE Link].
Ray Chaudhuri K, Rojo JM, Schapira AH, Brooks DJ, Stocchi F, Odin P, et al. A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need. PLoS One. 2013. 8(2):e57221. [QxMD MEDLINE Link]. [Full Text].
Johnson K. Nonmotor PD Symptoms Bolster Disease Severity Assessment. Medscape [serial online]. Available at http://www.medscape.com/viewarticle/812182. Accessed: October 13, 2013.
Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology. 2009 Nov 24. 73(21):1738-45. [QxMD MEDLINE Link]. [Full Text].
Weintraub D, Comella CL, Horn S. Parkinson's disease--Part 3: Neuropsychiatric symptoms. Am J Manag Care. 2008 Mar. 14(2 Suppl):S59-69. [QxMD MEDLINE Link].
Reid WG, Hely MA, Morris JG, Loy C, Halliday GM. Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study). J Neurol Neurosurg Psychiatry. 2011 Sep. 82(9):1033-7. [QxMD MEDLINE Link].
Parkinson's Tied to Higher Risk of Osteoporosis and Osteopenia. Medscape. Apr 3 2014. [Full Text].
Torsney KM, Noyce AJ, Doherty KM, et al. Bone health in Parkinson's disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2014 Mar 21. [QxMD MEDLINE Link].
Tolosa E, Gaig C, Santamaría J, Compta Y. Diagnosis and the premotor phase of Parkinson disease. Neurology. 2009 Feb 17. 72(7 Suppl):S12-20. [QxMD MEDLINE Link].
Fluorodopa F18 (fluorodeoxyphenylalanine 18F-DOPA) [package insert]. Manhasset, NY: Feinstein Institutes for Medical Research; Cyclotron/Radiochemistry Facility. October 2019. Available at [Full Text].
King J. New contrast agent enables earlier diagnosis in Parkinson's. Medscape Medical News. June 18, 2013. [Full Text].
Seibyl J, Jennings D, Grachev I, Coffey C, Marek K. Accuracy of DaTscan™ (ioflupane I 123 injection) in diagnosis of early parkinsonian syndromes (PS) [abstract 191]. Presented at: 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI); June 10, 2013; Vancouver, British Columbia, Canada.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004 Oct. 318(1):121-34. [QxMD MEDLINE Link].
Kang JH, Irwin DJ, Chen-Plotkin AS, Siderowf A, Caspell C, Coffey CS, et al. Association of Cerebrospinal Fluid ß-Amyloid 1-42, T-tau, P-tau181, and a-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease. JAMA Neurol. 2013 Aug 26. [QxMD MEDLINE Link].
Jeffrey S. Biomarkers for Parkinson's Diagnostic, Prognostic. Medscape [serial online]. Available at http://www.medscape.com/viewarticle/810262. Accessed: September 9, 2013.
Grosset D, Taurah L, Burn DJ, MacMahon D, Forbes A, Turner K, et al. A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. J Neurol Neurosurg Psychiatry. 2007 May. 78(5):465-9. [QxMD MEDLINE Link]. [Full Text].
Caslake R, Macleod A, Ives N, Stowe R, Counsell C. Monoamine oxidase B inhibitors versus other dopaminergic agents in early Parkinson's disease. Cochrane Database Syst Rev. 2009. (4):CD006661. [QxMD MEDLINE Link].
Antonini A, Cilia R. Behavioural adverse effects of dopaminergic treatments in Parkinson's disease: incidence, neurobiological basis, management and prevention. Drug Saf. 2009. 32(6):475-88. [QxMD MEDLINE Link].
Bayulkem K, Lopez G. Clinical approach to nonmotor sensory fluctuations in Parkinson's disease. J Neurol Sci. 2011 Nov 15. 310(1-2):82-5. [QxMD MEDLINE Link].
Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, et al. Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006 Apr 11. 66(7):996-1002. [QxMD MEDLINE Link].
[Guideline] Zesiewicz TA, Sullivan KL, Arnulf I, et al. Practice Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010 Mar 16. 74(11):924-31. [QxMD MEDLINE Link].
Stocchi F, Rascol O, Kieburtz K, et al. Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study. Ann Neurol. 2010 Jul. 68(1):18-27. [QxMD MEDLINE Link].
Hauser RA, McDermott MP, Messing S. Factors associated with the development of motor fluctuations and dyskinesias in Parkinson disease. Arch Neurol. 2006 Dec. 63(12):1756-60. [QxMD MEDLINE Link].
Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. 056 Study Group. N Engl J Med. 2000 May 18. 342(20):1484-91. [QxMD MEDLINE Link].
Constantinescu R, Romer M, McDermott MP, Kamp C, Kieburtz K. Impact of pramipexole on the onset of levodopa-related dyskinesias. Mov Disord. 2007 Jul 15. 22(9):1317-9. [QxMD MEDLINE Link].
Thomas A, Bonanni L, Gambi F, Di Iorio A, Onofrj M. Pathological gambling in Parkinson disease is reduced by amantadine. Ann Neurol. Sep 2010. 68(3):400-4.
Weintraub D, Sohr M, Potenza MN, Siderowf AD, Stacy M, Voon V, et al. Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study. Ann Neurol. 2010 Dec. 68(6):963-8. [QxMD MEDLINE Link].
Olanow CW, Kieburtz K, Odin P, Espay AJ, Standaert DG, Fernandez HH, et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 2014 Feb. 13(2):141-9. [QxMD MEDLINE Link].
Schapira AH, Fox SH, Hauser RA, Jankovic J, Jost WH, Kenney C, et al. Assessment of Safety and Efficacy of Safinamide as a Levodopa Adjunct in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial. JAMA Neurol. 2017 Feb 1. 74 (2):216-224. [QxMD MEDLINE Link].
Borgohain R, Szasz J, Stanzione P, Meshram C, Bhatt M, Chirilineau D, et al. Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations. Mov Disord. 2014 Feb. 29 (2):229-37. [QxMD MEDLINE Link]. [Full Text].
LeWitt PA, Hauser RA, Pahwa R, Isaacson SH, Fernandez HH, Lew M, et al. Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Neurology. 2019 Feb 01;18(2):145-154.
Mizuno Y, Hasegawa K, Kondo T, Kuno S, Yamamoto M, Japanese Istradefylline Study Group. Clinical efficacy of istradefylline (KW-6002) in Parkinson's disease: a randomized, controlled study. Mov Disord. 2010 Jul 30. 25 (10):1437-43. [QxMD MEDLINE Link].
Kondo T, Mizuno Y, Japanese Istradefylline Study Group. A long-term study of istradefylline safety and efficacy in patients with Parkinson disease. Clin Neuropharmacol. 2015 Mar-Apr. 38 (2):41-6. [QxMD MEDLINE Link].
Mizuno Y, Kondo T, Japanese Istradefylline Study Group. Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease. Mov Disord. 2013 Jul. 28 (8):1138-41. [QxMD MEDLINE Link]. [Full Text].
Schapira AH, Barone P, Hauser RA, Mizuno Y, Rascol O, Busse M, et al. Extended-release pramipexole in advanced Parkinson disease: a randomized controlled trial. Neurology. 2011 Aug 23. 77(8):767-74. [QxMD MEDLINE Link].
Ferreira JJ, Lees A, Rocha JF, Poewe W, Rascol O, Soares-da-Silva P. Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open-label extensions. Eur J Neurol. 2019 Jul. 26 (7):953-960. [QxMD MEDLINE Link]. [Full Text].
Pahwa R, Tanner CM, Hauser RA, Isaacson SH, Nausieda PA, Truong DD, et al. ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson Disease (EASE LID Study): A Randomized Clinical Trial. JAMA Neurol. 2017 Aug 1. 74 (8):941-949. [QxMD MEDLINE Link]. [Full Text].
Hauser RA, Pahwa R, Tanner CM, Oertel W, Isaacson SH, Johnson R, et al. ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson's Disease (EASE LID 2 Study): Interim Results of an Open-Label Safety Study. J Parkinsons Dis. 2017. 7 (3):511-522. [QxMD MEDLINE Link]. [Full Text].
Ory-Magne F, Corvol JC, Azulay JP, et al, on behalf of the NS-Park CIC Network. Withdrawing amantadine in dyskinetic patients with Parkinson disease: The AMANDYSK trial. Neurology. 2013 Dec 26. [QxMD MEDLINE Link].
Brooks M. Amantadine has lasting benefit on levodopa-induced dyskinesia. Medscape Medical News. January 8, 2014. [Full Text].
Barthel C, Nonnekes J, van Helvert M, Haan R, Janssen A, Delval A, et al. The laser shoes: A new ambulatory device to alleviate freezing of gait in Parkinson disease. Neurology. 2017 Dec 20. [QxMD MEDLINE Link].
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med. 1993 Jan 21. 328(3):176-83. [QxMD MEDLINE Link].
Shults CW. Effect of selegiline (deprenyl) on the progression of disability in early Parkinson's disease. Parkinson Study Group. Acta Neurol Scand Suppl. 1993. 146:36-42. [QxMD MEDLINE Link].
Palhagen S, Heinonen E, Hagglund J, Kaugesaar T, Maki-Ikola O, Palm R. Selegiline slows the progression of the symptoms of Parkinson disease. Neurology. 2006 Apr 25. 66(8):1200-6. [QxMD MEDLINE Link].
Tatton WG, Greenwood CE. Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. J Neurosci Res. 1991 Dec. 30(4):666-72. [QxMD MEDLINE Link].
Olanow C, Rascol O. Early Rasagaline treatment slows UPDRS decline in the ADAGIO delayed start study. Poster work in progress (WIP-11). 12th Congress of European Federation of Neurological Societies. Sept 23, 2008.
Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med. 2009 Sep 24. 361(13):1268-78. [QxMD MEDLINE Link].
A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol. 2002 Dec. 59(12):1937-43. [QxMD MEDLINE Link].
Hauser RA, Lew MF, Hurtig HI, Ondo WG, Wojcieszek J, Fitzer-Attas CJ. Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease. Mov Disord. 2009 Mar 15. 24(4):564-73. [QxMD MEDLINE Link].
A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol. 2004 Apr. 61(4):561-6. [QxMD MEDLINE Link].
Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 9. 351(24):2498-508. [QxMD MEDLINE Link].
Parkkinen L, O'Sullivan SS, Kuoppamäki M, Collins C, Kallis C, Holton JL, et al. Does levodopa accelerate the pathologic process in Parkinson disease brain?. Neurology. 2011 Oct 11. 77(15):1420-6. [QxMD MEDLINE Link].
Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002 Apr 3. 287(13):1653-61. [QxMD MEDLINE Link].
Schapira AH, Olanow CW. Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. JAMA. 2004 Jan 21. 291(3):358-64. [QxMD MEDLINE Link].
Suchowersky O, Gronseth G, Perlmutter J, Reich S, Zesiewicz T, Weiner WJ. Practice Parameter: neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006 Apr 11. 66(7):976-82. [QxMD MEDLINE Link].
Shemisa K, Hass CJ, Foote KD, Okun MS, Wu SS, Jacobson CE 4th, et al. Unilateral deep brain stimulation surgery in Parkinson's disease improves ipsilateral symptoms regardless of laterality. Parkinsonism Relat Disord. 2011 Dec. 17(10):745-8. [QxMD MEDLINE Link].
Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ Jr. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009 Jan 7. 301(1):63-73. [QxMD MEDLINE Link]. [Full Text].
Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med. 2010 Jun 3. 362(22):2077-91. [QxMD MEDLINE Link].
Brooks M. Neurostimulation has benefits in early Parkinson's disease. Medscape Medical News. February 15, 2013. [Full Text].
Schuepbach WM, Rau J, et al, for the EARLYSTIM Study Group. Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med. 2013 Feb 14. 368(7):610-22. [QxMD MEDLINE Link].
Foltynie T, Zrinzo L, Martinez-Torres I, Tripoliti E, Petersen E, Holl E, et al. MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety. J Neurol Neurosurg Psychiatry. 2011 Apr. 82(4):358-63. [QxMD MEDLINE Link].
Moreau C, Delval A, Defebvre L, Dujardin K, Duhamel A, Petyt G, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol. 2012 Jul. 11(7):589-596. [QxMD MEDLINE Link].
Castrioto A, Lozano AM, Poon YY, Lang AE, Fallis M, Moro E. Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation. Arch Neurol. 2011 Dec. 68(12):1550-6. [QxMD MEDLINE Link].
Oshima H, Katayama Y, Morishita T, Sumi K, Otaka T, Kobayashi K, et al. Subthalamic nucleus stimulation for attenuation of pain related to Parkinson disease. J Neurosurg. 2012 Jan. 116(1):99-106. [QxMD MEDLINE Link].
Kim HJ, Jeon BS, Paek SH. Effect of deep brain stimulation on pain in Parkinson disease. J Neurol Sci. 2011 Nov 15. 310(1-2):251-5. [QxMD MEDLINE Link].
Kim HJ, Jeon BS, Lee JY, Paek SH, Kim DG. The benefit of subthalamic deep brain stimulation for pain in Parkinson disease: a 2-year follow-up study. Neurosurgery. 2012 Jan. 70(1):18-23; discussion 23-4. [QxMD MEDLINE Link].
Broen M, Duits A, Visser-Vandewalle V, Temel Y, Winogrodzka A. Impulse control and related disorders in Parkinson's disease patients treated with bilateral subthalamic nucleus stimulation: a review. Parkinsonism Relat Disord. 2011 Jul. 17(6):413-7. [QxMD MEDLINE Link].
Timmermann L, Jain R, Chen L, Brucke T, Seijo F, San Martin ES, et al. 134 VANTAGE Trial: Three-Year Outcomes of a Prospective, Multicenter Trial Evaluating Deep Brain Stimulation With a New Multiple-Source, Constant-Current Rechargeable System in Parkinson Disease. Neurosurgery. 2016 Aug. 63 Suppl 1:155. [QxMD MEDLINE Link].
Svennilson E, Torvik A, Lowe R, Leksell L. Treatment of parkinsonism by stereotatic thermolesions in the pallidal region. A clinical evaluation of 81 cases. Acta Psychiatr Scand. 1960. 35:358-77. [QxMD MEDLINE Link].
Laitinen LV, Bergenheim AT, Hariz MI. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J Neurosurg. 1992 Jan. 76(1):53-61. [QxMD MEDLINE Link].
Lang AE, Widner H. Deep brain stimulation for Parkinson's disease: patient selection and evaluation. Mov Disord. 2002. 17 Suppl 3:S94-101. [QxMD MEDLINE Link].
Okun MS, Fernandez HH, Pedraza O, Misra M, Lyons KE, Pahwa R. Development and initial validation of a screening tool for Parkinson disease surgical candidates. Neurology. 2004 Jul 13. 63(1):161-3. [QxMD MEDLINE Link].
Olanow CW, Kordower JH, Lang AE, Obeso JA. Dopaminergic transplantation for Parkinson's disease: current status and future prospects. Ann Neurol. 2009 Nov. 66(5):591-6. [QxMD MEDLINE Link].
Silberstein P, Bittar RG, Boyle R, Cook R, Coyne T, O'Sullivan D. Deep brain stimulation for Parkinson's disease: Australian referral guidelines. J Clin Neurosci. 2009 Aug. 16(8):1001-8. [QxMD MEDLINE Link].
Stover NP, Watts RL. Spheramine for treatment of Parkinson's disease. Neurotherapeutics. 2008 Apr. 5(2):252-9. [QxMD MEDLINE Link].
Farag ES, Vinters HV, Bronstein J. Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease. Neurology. 2009 Oct 6. 73(14):1095-102. [QxMD MEDLINE Link]. [Full Text].
Witt J, Marks WJ Jr. An update on gene therapy in Parkinson's disease. Curr Neurol Neurosci Rep. 2011 Aug. 11(4):362-70. [QxMD MEDLINE Link].
Lewitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, et al. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol. 2011 Apr. 10(4):309-19. [QxMD MEDLINE Link].
Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, et al. Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006 Apr 11. 66(7):996-1002. [QxMD MEDLINE Link].
Frisina PG, Borod JC, Foldi NS, Tenenbaum HR. Depression in Parkinson''s disease: Health risks, etiology, and treatment options. Neuropsychiatr Dis Treat. 2008 Feb. 4(1):81-91. [QxMD MEDLINE Link]. [Full Text].
Barbas NR. Cognitive, affective, and psychiatric features of Parkinson's disease. Clin Geriatr Med. 2006 Nov. 22(4):773-96, v-vi. [QxMD MEDLINE Link].
Truong DD, Bhidayasiri R, Wolters E. Management of non-motor symptoms in advanced Parkinson disease. J Neurol Sci. 2008 Mar 15. 266(1-2):216-28. [QxMD MEDLINE Link].
Ziemssen T, Reichmann H. Non-motor dysfunction in Parkinson's disease. Parkinsonism Relat Disord. 2007 Aug. 13(6):323-32. [QxMD MEDLINE Link].
Hassan A, Bower JH, Kumar N, Matsumoto JY, Fealey RD, Josephs KA, et al. Dopamine agonist-triggered pathological behaviors: Surveillance in the PD clinic reveals high frequencies. Parkinsonism Relat Disord. 2011 May. 17(4):260-4. [QxMD MEDLINE Link].
Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, et al. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology. 2012 Apr 17. 78(16):1229-1236. [QxMD MEDLINE Link].
Barone P, Poewe W, Albrecht S, Debieuvre C, Massey D, Rascol O, et al. Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010 Jun. 9(6):573-80. [QxMD MEDLINE Link].
Allain H, Pollak P, Neukirch HC. Symptomatic effect of selegiline in de novo Parkinsonian patients. The French Selegiline Multicenter Trial. Mov Disord. 1993. 8 Suppl 1:S36-40. [QxMD MEDLINE Link].
Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, et al. Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet. 2014 Feb 8. 383 (9916):533-40. [QxMD MEDLINE Link].
Treatment of Parkinson's disease. Psychological disorders: striking a balance in order to optimise antiparkinsonian treatment. Prescrire Int. 2011 Oct. 20(120):242-5. [QxMD MEDLINE Link].
Ferreri F, Agbokou C, Gauthier S. Recognition and management of neuropsychiatric complications in Parkinson's disease. CMAJ. 2006 Dec 5. 175(12):1545-52. [QxMD MEDLINE Link].
Okai D, Askey-Jones S, Samuel M, O'Sullivan SS, Chaudhuri KR, Martin A, et al. Trial of CBT for impulse control behaviors affecting Parkinson patients and their caregivers. Neurology. 2013 Feb 26. 80(9):792-799. [QxMD MEDLINE Link]. [Full Text].
Anderson P. Cognitive Therapy Controls Impulse Behaviors in Parkinson's. Available at http://www.medscape.com/viewarticle/779914. Accessed: March 21, 2013.
Brooks M. Naltrexone for Impulse Control Disorders in Parkinson's?. Medscape Medical News. Available at http://www.medscape.com/viewarticle/829633. Accessed: August 9, 2014.
Papay K, Xie SX, Stern M, Hurtig H, Siderowf A, Duda JE, et al. Naltrexone for impulse control disorders in Parkinson disease: A placebo-controlled study. Neurology. 2014 Jul 18. [QxMD MEDLINE Link].
Friedman JH, Millman RP. Sleep disturbances and Parkinson's disease. CNS Spectr. 2008 Mar. 13(3 Suppl 4):12-7. [QxMD MEDLINE Link].
Tomlinson CL, Patel S, Meek C, Clarke CE, Stowe R, Shah L, et al. Physiotherapy versus placebo or no intervention in Parkinson's disease. Cochrane Database of Systematic Reviews. Feb 2012.
Ahlskog JE. Does vigorous exercise have a neuroprotective effect in Parkinson disease?. Neurology. 2011 Jul 19. 77(3):288-94. [QxMD MEDLINE Link]. [Full Text].
Herd CP, Tomlinson CL, Deane KHO, Brady MC, Smith CH, Sackley C, et al. Speech and language therapy versus placebo or no intervention for speech problems in Parkinson's disease. Cochrane Database Syst Rev. 2011 Apr 11. CD002812.
Fahn S. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease. Ann Neurol. 1992. 32 Suppl:S128-32. [QxMD MEDLINE Link].
Berke GS, Gerratt B, Kreiman J, Jackson K. Treatment of Parkinson hypophonia with percutaneous collagen augmentation. Laryngoscope. 1999 Aug. 109(8):1295-9. [QxMD MEDLINE Link].
Kim HJ, Jeon BS, Paek SH. Effect of deep brain stimulation on pain in Parkinson disease. J Neurol Sci. 2011 Nov 15. 310(1-2):251-5. [QxMD MEDLINE Link].
Hauser RA. Future treatments for Parkinson's disease: surfing the PD pipeline. Int J Neurosci. 2011. 121 Suppl 2:53-62. [QxMD MEDLINE Link].
Koller WC. Levodopa in the treatment of Parkinson's disease. Neurology. 2000. 55(11 Suppl 4):S2-7; discussion S8-12. [QxMD MEDLINE Link].
Marks WJ Jr, Bartus RT, Siffert J, et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec. 9(12):1164-72. [QxMD MEDLINE Link].
PBR Regulatory Affairs. Teva's AZILECT gets FDA approval to treat all stages of Parkinson’s disease. June 10, 2014. Available at http://regulatoryaffairs.pharmaceutical-business-review.com/news/tevas-azilect-gets-fda-approval-to-treat-all-stages-of-parkinsons-disease-100614-4289261. Accessed: June 16, 2014.
[Guideline] Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and pharmacological management of Parkinson's disease. A national clinical guideline. Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network (SIGN); 2010 Jan. 61 p. (SIGN publication; no. 113). [Full Text].
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct. 59(10):1541-50. [QxMD MEDLINE Link].
Teva Pharmaceutical Industries Ltd. FDA approves expanded label for AZILECT for treatment across all stages of Parkinson’s disease [press release]. June 9, 2014. Available at http://ir.tevapharm.com/phoenix.zhtml?c=73925&p=irol-newsArticle&ID=1938203&highlight=. Accessed: June 16, 2014.
Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003 Jul. 54(1):93-101. [QxMD MEDLINE Link].